ChemicalBook > CAS DataBase List > B-Raf inhibitor 1
B-Raf inhibitor 1
- Product Name
- B-Raf inhibitor 1
- CAS No.
- 1093100-40-3
- Chemical Name
- B-Raf inhibitor 1
- Synonyms
- CS-927;or Base;B-RAFcas;Raf inhibitor 1;B-Raf inhibitor 1;BRAF inhibitor 13;B-Raf inhibitor 1 Base;B-Raf inhibitor 1, >=98%;N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine;N5-(3-(7H-purin-6-yl)pyridin-2-yl)-N1-(4-chlorophenyl)-6-methylisoquinoline-1,5-diamine
- CBNumber
- CB12652787
- Molecular Formula
- C26H19ClN8
- Formula Weight
- 478.94
- MOL File
- 1093100-40-3.mol
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B-Raf inhibitor 1 Property
- Boiling point:
- 735.4±60.0 °C(Predicted)
- Density
- 1.461±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥ 47.9mg/mL in DMSO
- pka
- 8.41±0.10(Predicted)
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Safety
- HS Code
- 2933998090
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N-Bromosuccinimide Price
Apolloscientific
- Product number
- BISN0223
- Product name
- B-Raf inhibitor 1
- Packaging
- 1mg
- Price
- $75
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B1172
- Product name
- B-Rafinhibitor1
- Packaging
- 5mg
- Price
- $105
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-2182
- Product name
- Rafinhibitor1
- Purity
- 98.05%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
Apolloscientific
- Product number
- BISN0223
- Product name
- B-Raf inhibitor 1
- Packaging
- 5mg
- Price
- $156
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-2182
- Product name
- Rafinhibitor1
- Purity
- 98.05%
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
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B-Raf inhibitor 1 Chemical Properties,Usage,Production
Biological Activity
B-Raf inhibitor 1 is a potent Raf kinase inhibitor for B-RafWT, B-RafV600E, and C-Raf with Ki of 1 nM, 1 nM, and 0.3 nM, respectively.
in vitro
Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC 50 s of 0.31 and 0.72 μM, respectively. Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif.
target
| B-Raf < span> 1 nM (Ki) | B-Raf V600E 1 nM (Ki) | c-Raf 0.3 nM (Ki ) |
B-Raf inhibitor 1 Preparation Products And Raw materials
Raw materials
Preparation Products
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