(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine

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(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine

Product Name: (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine
CAS No.: 327623-37-0
Chemical Name: (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine
Synonyms: Aprepitant Impurity 1;Aprepitant Impurity 11;Fosaprepitant Impurity 30;Aprepitant M2 Metabolite Enantiomer;Aprepitant Impurity 1 Hydrochloride;Aprepitant Impurity 10 Hydrochloride;Aprepitant M2 Metabolite (1S, 2S, 3R)-Isomer;Des-1,2,4-triazol-3-one-5-methyl(2S,3R,1’Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'S)-Aprepitant;(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine
CBNumber: CB12657010
Molecular Formula: C20H18F7NO2
Formula Weight: 437.35
MOL File: 327623-37-0.mol

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(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine Property

Boiling point:: 387.9±42.0 °C(Predicted)
Density: 1.37±0.1 g/cm3(Predicted)
pka: 6.93±0.60(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D297830
Product name: Des-1,2,4-triazol-3-one-5-methyl(2S,3R,1''S)-Aprepitant
Packaging: 1mg
Price: $90
Updated: 2021/12/16

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(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine Chemical Properties,Usage,Production

Uses

Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1''S)-Aprepitant is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.

(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine Preparation Products And Raw materials

Raw materials

Preparation Products

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327623-37-0, (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)MorpholineRelated Search:

(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine Aprepitant Fosaprepitant dimeglumine Aprepitant Aprepitant Aprepitant Fosaprepitant Impurity 6 (2R,3S)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride [2R-[2aR*),3a]-2-[1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE Aprepitant Fosaprepitant Impurity 5 5-(hydroxymethyl)-1,2-dihydro-1,2,4-triazol-3-one (S)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-4-benzylMorpholin-3-one 1,1,1-Trimethoxy-2-chloroethane Aprepitant Benzyl dihydrogen phosphate

(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine

(2S,3R)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride

(2S,3R)-2-[(1S)-1-(3,5-bis-trifluoro-Methylphenyl)ethoxy]-3-(4-fluorophenyl)Morpholine

Aprepitant Impurity 1

Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'S)-Aprepitant

Aprepitant Impurity 11

Aprepitant M2 Metabolite (1S, 2S, 3R)-Isomer

Fosaprepitant Impurity 30

Aprepitant Impurity 1 Hydrochloride

Aprepitant M2 Metabolite Enantiomer

Morpholine, 2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, (2S,3R)-

Des-1,2,4-triazol-3-one-5-methyl(2S,3R,1&rsquo

Aprepitant Impurity 10 Hydrochloride

327623-37-0