Biochem/physiol Actions
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SR9011

Biochem/physiol Actions
Product Name
SR9011
CAS No.
1379686-29-9
Chemical Name
SR9011
Synonyms
SR9001;SR9011;CS-2028;SR-90011;SR-9011;SR 9011;Stenabolic Sr9011;SR9011 Sarms powder;SR-9011;SR 9011;SR9011;White Powder SR9011Cas# 1379686-29-9 Raw Chemical Material;Trifunctional Methacrylate Monomer Sarm Steroids Powder Sr9011
CBNumber
CB12672925
Molecular Formula
C23H31ClN4O3S
Formula Weight
479.04
MOL File
1379686-29-9.mol
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SR9011 Property

Boiling point:
642.8±50.0 °C(Predicted)
Density 
1.254±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
14.71±0.40(Predicted)
color 
Dark Yellow to Very Dark Brown
InChI
InChI=1S/C23H31ClN4O3S/c1-2-3-4-12-25-23(29)27-13-11-19(16-27)15-26(14-18-5-7-20(24)8-6-18)17-21-9-10-22(32-21)28(30)31/h5-10,19H,2-4,11-17H2,1H3,(H,25,29)
InChIKey
PPUYOYQTTWJTIU-UHFFFAOYSA-N
SMILES
N1(C(NCCCCC)=O)CCC(CN(CC2=CC=C(Cl)C=C2)CC2SC([N+]([O-])=O)=CC=2)C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11930
Product name
SR 9011
Purity
≥98%
Packaging
1mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
11930
Product name
SR 9011
Purity
≥98%
Packaging
5mg
Price
$384
Updated
2024/03/01
TRC
Product number
S684260
Product name
SR9011
Packaging
25mg
Price
$2180
Updated
2021/12/16
AK Scientific
Product number
4689DN
Product name
SR-9011
Packaging
5mg
Price
$525
Updated
2021/12/16
ApexBio Technology
Product number
B1768
Product name
SR9011
Packaging
2mg
Price
$126
Updated
2021/12/16
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SR9011 Chemical Properties,Usage,Production

Biochem/physiol Actions

SR9011 is a potent nuclear receptor REV-ERB agonist (EC50 of REV-ERBα- and REV-ERBβ-dependent repressor activity = 790 and 560 nM, respectively, by cell-based reporter assay) that stimulates REV-ERB-dependent target genes suppression both in cultures in vitro and in mice in vivo (100 mg/kg i.p., b.i.d.) without activity toward a panel of 46 other nuclear receptors. SR9011 is shown to modulate circadian behavior by suppressing the transcription factors BMAL1 (brain and muscle ARNT-like protein 1) and CLOCK (circadian locomotor output cycles kaput) as well as induce energy expenditure and weight loss by regulating genes involved in lipid and glucose metabolism in mice in vivo with good bioavailabiilty (plasma conc. = 0.53 and 15.3 μM 2 hr post 10 or 100 mg/kg i.p. dosage; brain conc. = 0.24 μM 2 hr post 10 mg/kg i.p.), while its structure analog GSK4112 shows no plasma exposure.

Uses

SR 9011 is a synthetic REV-ERBα/β agonist with activity in vivo. It is a lead compound for a new class of cancer drugs associated with the body’s circadian clock.

Application

SR9011 has been used as a nuclear receptor subfamily 1 group D member 1 (NR1D1) receptor agonist:
to study its effects on microglial immune-metabolism
to study its effects on insulin secretion from human type 2 diabetes islet cells
to study its effects on thyroid-stimulating hormone β (TSHβ) gene expression

SR9011 Preparation Products And Raw materials

Raw materials

Preparation Products

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SR9011 Suppliers

Australia 1 China 124 India 1 United States 11 Global 137
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4662
Advantage
60
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9926
Advantage
65
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View Lastest Price from SR9011 manufacturers

Dorne Chemical Technology co. LTD
Product
SR9011 1379686-29-9
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2024-03-26
Wuhan Cell Pharmaceutical Co., Ltd
Product
SR9011 1379686-29-9
Price
US $9.90-17337.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2023-03-30
hebei hongtan Biotechnology Co., Ltd
Product
SR9011 1379686-29-9
Price
US $90.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
1000
Release date
2024-03-21

1379686-29-9, SR9011Related Search:

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  • SR-9011;SR 9011;SR9011
  • CS-2028
  • SR9011
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  • Stenabolic Sr9011
  • White Powder SR9011Cas# 1379686-29-9 Raw Chemical Material
  • SR-9011;SR 9011
  • SR-90011
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  • Trifunctional Methacrylate Monomer Sarm Steroids Powder Sr9011
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  • SR9011 Sarms powder
  • 3-({(4-Chlorobenzyl)[(5-nitro-2-thienyl)methyl]amino}methyl)-N-pentyl-1-pyrrolidinecarboxamide
  • 1379686-29-9
  • C23H31ClN4O3S
  • 1379686-29-9
  • SARMS