TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE

Product Name: TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE
CAS No.: 177906-48-8
Chemical Name: TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE
Synonyms: N-BOC-TRANS-1,4-CYCLOHEXANEDIAMINE;trans-4-(Boc-amino)cyclohexanamine;N-Boc-transcyclohexanediamine;trans-4-(Boc-aMino)cyclohexylaMine;TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE;Trans-N-Boc-cyclohexane-1,4-diamine;1-N-BOC-TRANS-1,4-CYCLOHEXYLDIAMINE;Trans-1-N-Boc-1,4-Cyclohexanediamine;Trans-1N-Boc-cyclohexane-1,4-diamine;trans-4-(Boc-amino)cyclohexylamine,97%
CBNumber: CB1268261
Molecular Formula: C11H22N2O2
Formula Weight: 214.3
MOL File: 177906-48-8.mol

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TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE Property

Boiling point:: 322.1±31.0 °C(Predicted)
Density: 1.02±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
pka: 12.44±0.40(Predicted)
color: White
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C11H22N2O2/c1-11(2,3)15-10(14)13-9-6-4-8(12)5-7-9/h8-9H,4-7,12H2,1-3H3,(H,13,14)/t8-,9-
InChIKey: FEYLUKDSKVSMSZ-KYZUINATSA-N
SMILES: C(OC(C)(C)C)(=O)N[C@@H]1CC[C@@H](N)CC1
CAS DataBase Reference: 177906-48-8(CAS DataBase Reference)

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Safety

HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B646235
Product name: trans-N-Boc-1,4-cyclohexanediamine
Packaging: 1g
Price: $120
Updated: 2021/12/16

Usbiological

Product number: 239999
Product name: N-Boc-trans-1,4-cyclohexanediamine
Packaging: 1g
Price: $289
Updated: 2021/12/16

Apolloscientific

Product number: OR7177
Product name: trans-Cyclohexane-1,4-diamine,N-BOCprotected
Packaging: 1g
Price: $16
Updated: 2021/12/16

Matrix Scientific

Product number: 073418
Product name: trans-N-Boc-1,4-cyclohexanediamine
Purity: 95+%
Packaging: 1g
Price: $22
Updated: 2021/12/16

ChemScene

Product number: CS-B0868
Product name: tert-Butyltrans-N-(4-aminocyclohexyl)carbamate
Purity: ≥98.0%
Packaging: 5g
Price: $34
Updated: 2021/12/16

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TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE Chemical Properties,Usage,Production

Uses

trans-4-(Boc-amino)cyclohexylamine is used in the preparation of orally bioavailable and selective V1A receptor antagonist.

Uses

trans-N-Boc-1,4-cyclohexanediamine is used in the preparation of orally bioavailable and selective V1A receptor antagonist.

Synthesis

24424-99-5

2615-25-0

177906-48-8

Example 17. General procedure for the synthesis of tert-butyl trans-(4-aminocyclohexyl)carbamate (SB1-E-21-1) from di-tert-butyl dicarbonate and trans-1,4-cyclohexanediamine: To a methanol (100 mL) solution of SM-21-1 (2.0 g, 17.5 mmol) was slowly added dropwise a methanol (60 mL) solution of di-tert-butyl dicarbonate (1.1 g, 5.04 mmol). ) solution in methanol (60 mL) for 30 minutes. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure. Water (50 mL) was added to the residue and stirring was continued for 20 minutes at room temperature, followed by filtration. The filtrate was extracted with ethyl acetate (120 mL x 2), and the organic phases were combined and washed sequentially with water (50 mL x 2) and saturated saline (50 mL x 2). The organic phase was dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to remove the solvent to afford the target product SB1-E-21-1 (off-white solid, 900 mg, 83% yield).

References

[1] Chemistry - An Asian Journal, 2010, vol. 5, # 4, p. 877 - 886
[2] Patent: WO2016/160617, 2016, A2. Location in patent: Paragraph 00401
[3] Journal of Organic Chemistry, 1996, vol. 61, # 25, p. 8811 - 8818
[4] Patent: WO2016/116563, 2016, A1. Location in patent: Page/Page column 34-35
[5] Patent: WO2008/57468, 2008, A1. Location in patent: Page/Page column 352

TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE Suppliers

Canada 1 China 193 France 1 Germany 1 India 2 United Kingdom 3 United States 28 Global 229

Chengdu Firster Pharmaceutical Co., Ltd.

Tel: 028-87078428 028-87074958
Fax: 8772-8116
Email: chengzhenyong@cdfirster.com
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Shanghai Balmxy Pharmaceutical Co., Ltd

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J & K SCIENTIFIC LTD.

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Nanjing Chemlin Chemical Co., Ltd

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Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
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View Lastest Price from TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE manufacturers

Wuhan Han Sheng New Material Technology Co.，Ltd

Product: TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE 177906-48-8
Price: US $8.50/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 15MT
Release date: 2023-09-15

Wuhan Han Sheng New Material Technology Co.，Ltd

Product: N-Boc-transcyclohexanediamine 177906-48-8
Price: US $8.60/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 15MT
Release date: 2023-09-15

Wuhan Han Sheng New Material Technology Co.，Ltd

Product: Trans-1-(N-Boc AMino)-4-AMino cyclohexane 177906-48-8
Price: US $8.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 15MT
Release date: 2023-09-15

177906-48-8, TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINERelated Search:

TRANS-1,4-CYCLOHEXANEDICARBOXYLIC ACID MONOMETHYL ESTER DIMETHYL TRANS-1,4-CYCLOHEXANEDICARBOXYLATE Trans-(4-aminomethylcyclohexyl)acetic acid HCl trans-3-fluoro-3-methylcyclobutane-1-carboxylic acid Fmoc-L-hydroxyproline Z-HYP-OME TERT-BUTYL TRANS-4-FORMYLCYCLOHEXYLCARBAMATE Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate Monomethyl fumarate Dibutyl fumarate trans-4-Aminocyclohexanemethanol (4-aminocyclohexyl)methanol CYCLOHEXANE CARBONYL CHLORLDE Trans-N-Boc-1,2-Cyclohexanediamine TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE N-Boc-1,4-cyclohexanediamine trans-1,4-Diaminocyclohexane (1S,2S)-trans-N-Boc-1,2-Cyclohexanediamine

N-Boc-transcyclohexanediamine

tert-butyl (1r,4r)-4-aminocyclohexylcarbamate

tert-Butyl (trans-4-aminocyclohex-1-yl)carbamate, trans-1,4-Diaminocyclohexane, N-BOC protected

trans-Cyclohexane-1,4-diamine, N-BOC protected

rel-tert-butyl N-[(1R,4R)-4-aMinocyclohexyl]carbaMate

trans-4-(Boc-aMino)cyclohexylaMine

Trans-1-(N-Boc AMino)-4-AMino cyclohexane

tert-butyl ((1r,4r)-4-aMinocyclohexyl)carbaMate hydrochloride

Trans-1-N-Boc-1,4-Cyclohexanediamine

tert-Butyl trans-N-(4-aminocyclohexyl)carbamate

trans-N-Boc-1,4-cyclohexanediamine, >=98%

trans-tert-Butyl (4-aminocyclohexyl) carbamate

Trans-N-Boc-cyclohexane-1,4-diamine

N-BOC-TRANS-1,4-CYCLOHEXANEDIAMINE

TERT-BUTYL TRANS-4-AMINOCYCLOHEXYLCARBAMATE

TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE

TRANS-(4-AMINO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER

TRANS-1-BOC-AMINO-1,4-CYCLOHEXANEDIAMINE

1-N-BOC-TRANS-1,4-CYCLOHEXYLDIAMINE

CarbaMic acid, N-(trans-4-aMinocyclohexyl)-, 1,1-diMethylethyl ester

trans-4-(Boc-amino)cyclohexanamine

Trans-1N-Boc-cyclohexane-1,4-diamine

trans-Cyclohexane-1,4-diamine, N1-BOC protected

trans-4-(Boc-amino)cyclohexylamine,97%

1,1-Dimethylethyl N-(trans-4-aminocyclohexyl)carbamate

tert-Butyl N-(trans-4-aminocyclohexyl)-carbamate

177906-48-8

pharmacetical

177906-48-8