ledipasvir interMediate

Product Name: ledipasvir interMediate
CAS No.: 1256387-87-7
Chemical Name: ledipasvir interMediate
Synonyms: (1R,3S,4S);Ledipasvir Impurity 12;Ledipasvir Intermediate 1;Intermediate of Redipavir;Ledipasvir Intermediate 09;2-Azabicyclo[2.2.1]heptane-2-carboxylic acid;(1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl...;(1R,3S,4S)-3-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-ethyl ester;2-[(1R,3S,4S)-2-Boc-2-azabicyclo[2.2.1]heptan-3-yl]-1H-benzimidazole-6-boronic Acid Pinacol Ester;(1R,3S,4S)-2-tert-Butyl-3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-benzo[d]imidazol-2-yl)
CBNumber: CB12710876
Molecular Formula: C24H34BN3O4
Formula Weight: 439.36
MOL File: 1256387-87-7.mol

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ledipasvir interMediate Property

Boiling point:: 613.5±35.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 12.16±0.10(Predicted)
Appearance: Off-white to light yellow Solid
InChIKey: MYPUONINDNZBTH-GMBSWORKSA-N
SMILES: [C@]12([H])C[C@]([H])(CC1)[C@@H](C1NC3=CC(B4OC(C)(C)C(C)(C)O4)=CC=C3N=1)N2C(OC(C)(C)C)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-M3581
Product name: 2-Azabicyclo[2.2.1]heptane-2-carboxylicacid,3-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-,1,1-dimethylethylester,(1R,3S,4S)-
Purity: ≥99.0%
Packaging: 1g
Price: $66
Updated: 2021/12/16

ChemScene

Product number: CS-M3581
Product name: 2-Azabicyclo[2.2.1]heptane-2-carboxylicacid,3-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-,1,1-dimethylethylester,(1R,3S,4S)-
Purity: ≥99.0%
Packaging: 5g
Price: $212
Updated: 2021/12/16

AK Scientific

Product number: 9595AF
Product name: (1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylicacid1,1-dimethylethylester
Packaging: 5g
Price: $460
Updated: 2021/12/16

Ambeed

Product number: A242722
Product name: (1R,3S,4S)-tert-Butyl3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate
Purity: 95+%
Packaging: 100mg
Price: $19
Updated: 2021/12/16

Ambeed

Product number: A242722
Product name: (1R,3S,4S)-tert-Butyl3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate
Purity: 95+%
Packaging: 250mg
Price: $27
Updated: 2021/12/16

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ledipasvir interMediate Chemical Properties,Usage,Production

Synthesis

1256387-74-2

99770-93-1

1256387-87-7

I. Preparation of Compound 613: tert-Butyl (1R,3S,4S)-3-(6-bromo-1H-benzo[d]imidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate (264 mg, 0.673 mmol), bis(pinacol) 1,4-phenylene diboronate (5 eq, 3.36 g, 6.95 mmol), tetrakis(triphenylphosphine) A mixture of palladium (5%, 39 mg) and 2M aqueous potassium carbonate (3 eq, 1.01 mL) in 5 mL of 1,2-dimethoxyethane (DME) was heated to 90°C for 4 hours under argon protection. After completion of the reaction, the reaction mixture was cooled, diluted with ethyl acetate and washed with saturated sodium bicarbonate solution. The organic layer was dried over anhydrous magnesium sulfate, concentrated, and purified by fast column chromatography (silica gel, 20% to 60% ethyl acetate/hexane gradient elution) to afford (1R,3S,4S)-3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2-yl)-2-azabicyclo[2.2.1] Heptane-2-carboxylic acid tert-butyl ester (295 mg, 85% yield).LCMS-ESI (m/z): [M+H]+ Calculated value C30H38BN3O4: 515.45; Measured value: 516.1.

References

[1] Patent: WO2013/40492, 2013, A2. Location in patent: Page/Page column 91-92
[2] Patent: US2013/273005, 2013, A1. Location in patent: Paragraph 0350

ledipasvir interMediate Preparation Products And Raw materials

Raw materials

Preparation Products

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ledipasvir interMediate Suppliers

China 134 India 4 United Kingdom 1 United States 3 Global 142

Sinbond Industiral Co., Ltd.

Tel: --
Fax: --
Email: cici1124@gmail.com
Country: United Kingdom
ProdList: 248
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View Lastest Price from ledipasvir interMediate manufacturers

Career Henan Chemical Co

Product: ledipasvir interMediate 1256387-87-7
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: ask
Release date: 2018-12-20

Shanghai Yingrui Biopharma Co., Ltd.

Product: (1R,3S,4S)-2-tert-Butyl-3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-benzo[d]imidazol-2-yl) 1256387-87-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100t
Release date: 2018-03-06

1256387-87-7, ledipasvir interMediateRelated Search:

ledipasvir interMediate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate (1S)-1-(diphenylphosphino)-2-[(1R)-1-(diphenylphosphino)ethyl]-Ferrocene (S)-1-[(R)-2-(DI-TERT.-BUTYLPHOSPHINO)FERROCENYL]ETHYLBIS(2-METHYLPHENYL)PHOSPHI (1R,2R)-(-)-1,2-Diaminocyclohexane (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Ledipasvir ledipasvir interMediate ledipasvir interMediate 2,7-DibroMo-9,9-difluoro-9H-fluorene (S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid 2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 3-(6-broMo-1H-benziMidazol-2-yl)-, 1,1-diMethylethyl ester,(1R,3S,4S)- (S)-5-BOC-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID 1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)-2-chloro-Ethanone ledipasvir interMediate (3S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxylic acid

Identification Name (1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1-dimethylethyl ester

tert-butyl (1R,3S,4S)-3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate

(1R,3S,4S)-2-tert-Butyl-3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-benzo[d]imidazol-2-yl)

(1R,3S,4S)-tert-butyl 3-(6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]iMidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate

Identification Name (1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-

2-Azabicyclo[2.2.1]heptane-2-carboxylic acid, 3-[6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benziMidazol-2-yl]-, 1,1-diMethylethyl ester, (1R,3S,4S)-

(1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylic acid 1,1-dimethylethyl ester

(1R,3S,4S)-2-tert-butyl-3-(6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[D]iMidazol-2-yl)-2-azabicyclo[2.2.1]hept

(1R,3S,4S)-2-tert-butyl-3-(6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[D]iMidazol-2-yl)-2-azabicyclo[2.2.1]heptane-2-carboxylate

2-Azabicyclo[2.2.1]heptane-2-carboxylic acid

Ledipasvir Intermediate 09

Ledipasvir Intermediate 1

(1R,3S,4S)-tert-butyl 3-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-inden-2-yl)-2-aza-bicyclo[2.2.1]heptane-2-carboxylate

(2-((1R,3S,4S)-2-(TERT-BUTOXYCARBONYL)-2-AZABICYCLO[2.2.1]HEPTAN-3-YL)-1H-BENZO[D]IMIDAZOL-6-YL)BORONIC ACID PINACOL ESTER

1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.

(1R,3S,4S)

(1R,3S,4S)-3-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-ethyl ester

3-{6-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-1H-benzoimidazol-2-yl}-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

Ledipasvir Impurity 12

tert-butyl (1S,2S,4R)-2-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-3-azabicyclo[2.2.1]heptane-3-carboxylate

(1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl...

(1R,3S,4S)-tert-butyl 3-(6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]iMidazol-2-)Q: What is (1R,3S,4S)-tert-butyl 3-(6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]iMidazol-2-) Q: What is the CAS Number of (1R,3S,4S)-tert-butyl 3-(6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]iMidazol-2-) Q: What is the storage condition of (1R,3S,4S)-tert-butyl 3-(6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]iMidazol-2-)

Intermediate of Redipavir

(1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-2-carboxylicacid1,1-dimethylethylChemicalbookester

2-[(1R,3S,4S)-2-Boc-2-azabicyclo[2.2.1]heptan-3-yl]-1H-benzimidazole-6-boronic Acid Pinacol Ester

1256387-87-7

C24H34BN3O4