LB-100

Product Name: LB-100
CAS No.: 1026680-07-8
Chemical Name: LB-100
Synonyms: LB-100;CS-1762;LB-100, >95%;LB-100, 1026680-07-8;3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID;3-(1-methylpiperazine-4-carbonyl)-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid;methyl 2,5-dimethyl-1-[(2-methylpropan-2-yl)oxycarbonylamino]pyrrole-3-carboxylate LB-100;LB-100 3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID
CBNumber: CB12725546
Molecular Formula: C13H20N2O4
Formula Weight: 268.3089
MOL File: 1026680-07-8.mol

More

Less

LB-100 Property

Melting point:: >214°C (dec.)
storage temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
solubility: DMSO (Very Slightly, Heated), Methanol (Very Slightly, Heated)
form: Solid
color: White

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

ApexBio Technology

Product number: B4846
Product name: LB-100
Packaging: 25mg
Price: $335
Updated: 2021/12/16

More

Less

LB-100 Chemical Properties,Usage,Production

Uses

LB-100 is a small molecule inhibitor of protein phosphatase 2A with potent chemo- and radio-sensitizing potential in variety of cancer types including pancreatic cancer and colorectal cancer of human and animal model.

Biological Activity

lb-100 is an inhibitor of protein phosphatase 2a (pp2a) with anticancer activity, with ic50 of 0.85 μm and 3.87 μm in bxpc-3 and panc-1 cells, respectively[1].in bxpc-3, panc-1, and sw1990 cells, lb-100 treatment reduced pp2a activity by 30-50%. lb-100 increases the intracellular doxorubicin concentration (about 2.5 times that of the control group) and makes tumor cells more sensitive to the cytotoxicity of doxorubicin[1].in a panc-1 mouse xenograft model, lb-100 (2 mg / kg, intraperitoneal injection) improves the efficacy of the chemotherapy drug doxorubicin. lb-100 increases tumor microvessel density and blood flow velocity on the tumor surface, and decreases tumor volume[1].[1]. bai x, zhi x, zhang q, et al. inhibition of protein phosphatase 2a sensitizes pancreatic cancer to chemotherapy by increasing drug perfusion via hif-1α-vegf mediated angiogenesis. cancer lett, 2014, 355(2): 281-287.

LB-100 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

LB-100 Suppliers

China 80 India 1 United States 8 Global 89

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

More

Less

View Lastest Price from LB-100 manufacturers

Career Henan Chemical Co

Product: LB-100 1026680-07-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98-100%
Supply Ability: 1000kg
Release date: 2018-08-20

1026680-07-8, LB-100Related Search:

Bortezomib MK-8776 (SCH 900776) 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE ABT 737 Cryptotanshinone Olaparib

3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID

LB-100

LB-100, >95%

CS-1762

3-(1-methylpiperazine-4-carbonyl)-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid

LB-100 3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID

methyl 2,5-dimethyl-1-[(2-methylpropan-2-yl)oxycarbonylamino]pyrrole-3-carboxylate LB-100

LB-100, 1026680-07-8

1026680-07-8

Inhibitors