ChemicalBook > CAS DataBase List > ESI 09

ESI 09

Product Name
ESI 09
CAS No.
263707-16-0
Chemical Name
ESI 09
Synonyms
ESI09;ESI 09;ESI-09;ESI-09, 10 mM in DMSO;Virus Protease,inhibit,ESI 09,ESI09,Inhibitor,ESI-09;2-(5-(tert-Butyl)isoxazol-3-yl)-N-(3-chlorophenyl)-2-oxoacetohydrazonoyl cyanide;(E)-2-(5-(tert-butyl)isoxazol-3-yl)-N-(3-chlorophenyl)-2-oxoacetohydrazonoyl cyanide;(E)-3-(5-tert-butylisoxazol-3-yl)-2-(2-(3-chlorophenyl)hydrazono)-3-oxopropanenitrile;alpha-[(3-Chlorophenyl)hydrazono]-5-(1,1-dimethylethyl)-beta-oxo-3-isoxazolepropanenitrile;α-[2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-b-oxo-3-isoxazolepropanenitrile
CBNumber
CB12729362
Molecular Formula
C16H15ClN4O2
Formula Weight
330.77
MOL File
263707-16-0.mol
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ESI 09 Property

Melting point:
>175°C (dec.)
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
color 
, faint yellow to dark orange
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0814
Product name
ESI-09
Purity
≥98% (HPLC)
Packaging
5mg
Price
$152
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0814
Product name
ESI-09
Purity
≥98% (HPLC)
Packaging
25mg
Price
$604
Updated
2024/03/01
Cayman Chemical
Product number
19130
Product name
ESI-09
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
19130
Product name
ESI-09
Purity
≥95%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
19130
Product name
ESI-09
Purity
≥95%
Packaging
10mg
Price
$153
Updated
2024/03/01
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ESI 09 Chemical Properties,Usage,Production

Uses

ESI 09 acts as an EPAC inhibitor, preventing EPAC-mediated insulin release form β-pancreatic cells. Selective control for EPAC over PKA and decreases migration and invasion of AsPc-1 and PANC-1 pancreatic cancer cells.

Biochem/physiol Actions

ESI-09 is a potent, specific inhibitor of EPAC (exchange protein directly activated by cAMP). ESI-09 inhibits EPAC1 and EPAC2 with IC50 values of 3.2 and 1.4 μM, respectively, with no activity against PKA at 25 μM. In pancreatic cell lines, the compound blocks phosphorylation of Akt and insulin secretion. ESI-09 inhibits migration of pancreatic cancer cell lines.

storage

Store at +4°C

ESI 09 Preparation Products And Raw materials

Raw materials

Preparation Products

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ESI 09 Suppliers

China 73 Germany 1 India 1 United Kingdom 1 United States 10 Global 86
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View Lastest Price from ESI 09 manufacturers

Career Henan Chemical Co
Product
ESI 09 263707-16-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-07-09

263707-16-0, ESI 09Related Search:

H-89 DIHYDROCHLORIDE HYDRATE Cilomilast bupivacaine hydrochloride Forskolin

  • α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile
  • ESI 09
  • ESI09
  • ESI-09
  • (E)-3-(5-tert-butylisoxazol-3-yl)-2-(2-(3-chlorophenyl)hydrazono)-3-oxopropanenitrile
  • α-[2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-b-oxo-3-isoxazolepropanenitrile
  • alpha-[(3-Chlorophenyl)hydrazono]-5-(1,1-dimethylethyl)-beta-oxo-3-isoxazolepropanenitrile
  • 3-Isoxazolepropanenitrile, α-[2-(3-chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-
  • (E)-2-(5-(tert-butyl)isoxazol-3-yl)-N-(3-chlorophenyl)-2-oxoacetohydrazonoyl cyanide
  • 3-?Isoxazolepropanenitr?ile, α-?[2-?(3-?chlorophenyl)?hydrazinylidene]?-?5-?(1,?1-?dimethylethyl)?-?β-?oxo-
  • 2-(5-(tert-Butyl)isoxazol-3-yl)-N-(3-chlorophenyl)-2-oxoacetohydrazonoyl cyanide
  • Virus Protease,inhibit,ESI 09,ESI09,Inhibitor,ESI-09
  • ESI-09, 10 mM in DMSO
  • 263707-16-0
  • Inhibitors