ESI 09

Product Name: ESI 09
CAS No.: 263707-16-0
Chemical Name: ESI 09
Synonyms: ESI09;ESI 09;ESI-09;Virus Protease,inhibit,ESI 09,ESI09,Inhibitor,ESI-09;2-(5-(tert-Butyl)isoxazol-3-yl)-N-(3-chlorophenyl)-2-oxoacetohydrazonoyl cyanide;(E)-2-(5-(tert-butyl)isoxazol-3-yl)-N-(3-chlorophenyl)-2-oxoacetohydrazonoyl cyanide;(E)-3-(5-tert-butylisoxazol-3-yl)-2-(2-(3-chlorophenyl)hydrazono)-3-oxopropanenitrile;alpha-[(3-Chlorophenyl)hydrazono]-5-(1,1-dimethylethyl)-beta-oxo-3-isoxazolepropanenitrile;α-[2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-b-oxo-3-isoxazolepropanenitrile;α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile
CBNumber: CB12729362
Molecular Formula: C16H15ClN4O2
Formula Weight: 330.77
MOL File: 263707-16-0.mol

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ESI 09 Property

Melting point:: >175°C (dec.)
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
color: , faint yellow to dark orange

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0814
Product name: ESI-09
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $152
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0814
Product name: ESI-09
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $604
Updated: 2024/03/01

Cayman Chemical

Product number: 19130
Product name: ESI-09
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19130
Product name: ESI-09
Purity: ≥95%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 19130
Product name: ESI-09
Purity: ≥95%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

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ESI 09 Chemical Properties,Usage,Production

Uses

ESI 09 acts as an EPAC inhibitor, preventing EPAC-mediated insulin release form β-pancreatic cells. Selective control for EPAC over PKA and decreases migration and invasion of AsPc-1 and PANC-1 pancreatic cancer cells.

Biochem/physiol Actions

ESI-09 is a potent, specific inhibitor of EPAC (exchange protein directly activated by cAMP). ESI-09 inhibits EPAC1 and EPAC2 with IC50 values of 3.2 and 1.4 μM, respectively, with no activity against PKA at 25 μM. In pancreatic cell lines, the compound blocks phosphorylation of Akt and insulin secretion. ESI-09 inhibits migration of pancreatic cancer cell lines.

storage

Store at +4°C

ESI 09 Preparation Products And Raw materials

Raw materials

Preparation Products

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ESI 09 Suppliers

China 68 Germany 1 India 1 United Kingdom 1 United States 10 Global 81

A.J Chemicals

Tel: --
Fax: --
Email: sales@ajchem.in
Country: India
ProdList: 6100
Advantage: 58

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View Lastest Price from ESI 09 manufacturers

Career Henan Chemical Co

Product: ESI 09 263707-16-0
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-07-09

263707-16-0, ESI 09Related Search:

H-89 DIHYDROCHLORIDE HYDRATE Cilomilast bupivacaine hydrochloride Forskolin

α-[(2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-3-isoxazolepropanenitrile

ESI 09

ESI09

ESI-09

(E)-3-(5-tert-butylisoxazol-3-yl)-2-(2-(3-chlorophenyl)hydrazono)-3-oxopropanenitrile

α-[2-(3-Chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-b-oxo-3-isoxazolepropanenitrile

alpha-[(3-Chlorophenyl)hydrazono]-5-(1,1-dimethylethyl)-beta-oxo-3-isoxazolepropanenitrile

3-Isoxazolepropanenitrile, α-[2-(3-chlorophenyl)hydrazinylidene]-5-(1,1-dimethylethyl)-β-oxo-

(E)-2-(5-(tert-butyl)isoxazol-3-yl)-N-(3-chlorophenyl)-2-oxoacetohydrazonoyl cyanide

3-?Isoxazolepropanenitr?ile, α-?[2-?(3-?chlorophenyl)?hydrazinylidene]?-?5-?(1,?1-?dimethylethyl)?-?β-?oxo-

2-(5-(tert-Butyl)isoxazol-3-yl)-N-(3-chlorophenyl)-2-oxoacetohydrazonoyl cyanide

Virus Protease,inhibit,ESI 09,ESI09,Inhibitor,ESI-09

263707-16-0

Inhibitors