ChemicalBook > CAS DataBase List > 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

Product Name
2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
CAS No.
1374356-45-2
Chemical Name
2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
Synonyms
(s)-g-fitinib;(S)-CRIZOTINIB;ent-crizotinib;Crizotinib, (S)-;Crizotinib S-Isomer;Crizotinib impurity A;Crizotinib Impurity 24;CRIZOTINIB, S-ENANTIOMER;CRIZOTINIB CHIRAL IMPURITY;3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
CBNumber
CB12729650
Molecular Formula
C21H22Cl2FN5O
Formula Weight
450.34
MOL File
1374356-45-2.mol
More
Less

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Property

Boiling point:
599.2±50.0 °C(Predicted)
Density 
1.47±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 5 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 0.5 mg/ml; Ethanol: 0.5 mg/ml
form 
A solid
pka
9.81±0.10(Predicted)
CAS DataBase Reference
1374356-45-2
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Tocris
Product number
6025
Product name
(S)-Crizotinib
Purity
≥98%(HPLC)
Packaging
10
Price
$137
Updated
2021/12/16
Tocris
Product number
6025
Product name
(S)-Crizotinib
Purity
≥98%(HPLC)
Packaging
50
Price
$578
Updated
2021/12/16
TRC
Product number
C785005
Product name
(S)-Crizotinib
Packaging
5mg
Price
$275
Updated
2021/12/16
TRC
Product number
C785005
Product name
(S)-Crizotinib
Packaging
2.5mg
Price
$180
Updated
2021/12/16
TRC
Product number
C785005
Product name
(S)-Crizotinib
Packaging
1mg
Price
$80
Updated
2021/12/16
More
Less

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Chemical Properties,Usage,Production

Characteristics

MTH1 (NUDT1)-selective inhibitor.

Uses

(S)-Crizotinib is the S-isomer of Crizotinib (C785000) and a novel potent, selective, and cell permeable MTH1 inhibitor. (S)-Crizotinib can also serve as a promising anticancer agent.

Definition

ChEBI: Ent-crizotinib is a 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that is the (S)-enantiomer of crizotinib. It is an enantiomer of a crizotinib.

Biological Activity

(S)-crizotinib, (S)enantiomer-crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.

target

TargetValue
MTH1
(Cell-free assay)		 72 nM

storage

Store at RT

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Suppliers

China 61 India 3 United Kingdom 2 United States 10 Global 76
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4659
Advantage
58
Shanghai Beckham Medical Technology Co., Ltd
Tel
021-13816613772 13816613772
Fax
QQ: 12922499
Email
huahero21@sina.com
Country
China
ProdList
359
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Shenzhen SUNGENING Bio-Medical Co., Ltd.
Tel
0755-28967200 13631290199
Fax
0755-28967200
Email
wxf@sungening.com
Country
China
ProdList
9507
Advantage
60
Shanghai He Huan Chemical Co., Ltd.
Tel
021-60345187 13917602471
Fax
021-60345187
Email
lzz841106@aliyun.com
Country
China
ProdList
9908
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4698
Advantage
58
TOSUN PHARM
Tel
020-61855200 13326451905
Email
2881290884@qq.com
Country
China
ProdList
7497
Advantage
58
Baoji Guokang Bio-Technology Co., Ltd.
Tel
0917-3909592 13892490616
Fax
09173909592
Email
gksales1@gk-bio.com
Country
China
ProdList
9335
Advantage
58
AFINE CHEMICALS LIMITED
Tel
0571-85134551 18958018566;
Fax
008657185134895
Email
info@afinechem.com
Country
China
ProdList
15377
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6313
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 15093356674;
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29826
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
chenjw@absin.cn
Country
China
ProdList
24734
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
Shanghai Luofa Biochemical Technology Co., Ltd.
Tel
021-51111890 15317326293
Email
sales@molnova.com
Country
China
ProdList
4196
Advantage
58
Shandong Wadesen Biotechnology Co. LTD
Tel
0531-88723173 18596073690
Email
1047208234@qq.com
Country
China
ProdList
3516
Advantage
58
SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD
Tel
0755-0755-0755-83725350 13380397412
Fax
0755-28094224
Email
3001280422@qq.com
Country
China
ProdList
9954
Advantage
58
Wuhan Yanzhe Technology Co., Ltd
Tel
15527250409
Fax
QQ：2692360204
Email
wenhaotian12@163.com
Country
China
ProdList
4576
Advantage
58
cjbscvictory
Tel
13348960310 13348960310
Email
3003867561@qq.com
Country
China
ProdList
9946
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44489
Advantage
58
Foshan Treasure Biotechnology Co., Ltd
Tel
0757-85921206 18520245316
Email
2329783215@qq.com
Country
China
ProdList
12664
Advantage
58
Nantong Feiyu Biological Technology CO.,LTD
Tel
0513-68819626; 13813788405
Fax
0513-68669626
Email
feiyubio2@163.com
Country
China
ProdList
4821
Advantage
58
QUALITY CONTROL SOLUTIONS LTD.
Tel
13670046396
Email
ORDERS@QCSRM.COM
Country
China
ProdList
18820
Advantage
58
Kaifeng Mingren Pharmaceutical Co.,LTD
Tel
0371-65741762
Fax
QQ：2860768577
Email
sales@hasunny.com
Country
China
ProdList
2380
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6712
Advantage
58
Shangqiu Ladybug Network Technology Co., LTD
Tel
0370-2059268 15672839268
Fax
03702782809
Email
2352713635@qq.com
Country
China
ProdList
4206
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24023
Advantage
58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
29803
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169109
Email
market03@meryer.com
Country
China
ProdList
27996
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
4030
Advantage
58
Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd
Tel
18502726233
Email
3641133981@qq.com
Country
China
ProdList
9295
Advantage
58
Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd
Tel
18162595016
Email
3287908757@qq.com
Country
China
ProdList
9887
Advantage
58
Hangzhou Bingochem Co., Ltd.
Tel
0571-87632989
Email
sales@bingochem.com
Country
China
ProdList
21673
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12007
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
+86-18521732826
Email
market@aladdin-e.com
Country
China
ProdList
48467
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9180
Advantage
58
LEAP CHEM CO., LTD.
Tel
+86-852-30606658
Email
market18@leapchem.com
Country
China
ProdList
24738
Advantage
58
Shanghai Minmin Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1914109725@qq.com
Country
CHINA
ProdList
6530
Advantage
58
Xiamen Huijia Biological Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6979
Advantage
58
Shanghai Jingke Chemical Technology Co., Ltd.
Tel
--
Fax
--
Email
jingkehuaxue@163.com
Country
CHINA
ProdList
6974
Advantage
58
Guangzhou Weijia Technology Co., Ltd.
Tel
--
Fax
--
Email
WHIGA22@126.COM
Country
CHINA
ProdList
6748
Advantage
58
Shanghai Gaochuang Chemical Technology Co., Ltd.
Tel
--
Fax
--
Email
gaochem@163.com
Country
CHINA
ProdList
6995
Advantage
58
Beijing Baiao Innovation Technology Co., Ltd.
Tel
--
Fax
--
Email
3007606172@qq.com
Country
CHINA
ProdList
6005
Advantage
58
Beijing Chief-East Tech Co.,Ltd (Qwbio)
Tel
--
Fax
--
Email
info@qwbio.com
Country
China
ProdList
6912
Advantage
50
Beijing Bolide Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1985563437@qq.com
Country
CHINA
ProdList
6172
Advantage
58
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6921
Advantage
58
Shanghai Gantu Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
1920192055@qq.com
Country
CHINA
ProdList
1843
Advantage
58
Nanjing Sai Ruirui Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
sales@shrbio.com
Country
CHINA
ProdList
6873
Advantage
58
More
Less

View Lastest Price from 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- manufacturers

Career Henan Chemical Co
Product
2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- 1374356-45-2
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200g
Release date
2020-02-01

1374356-45-2, 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-Related Search:

Lead Selenium Diethyl sulfate LEUHISTIN Angeli’s Salt Lignosulfonic acid Everolimus KU-55933 (ATM Kinase Inhibitor) Sunitinib Malate Crizotinib TH588 AZD-9291

  • (S)-CRIZOTINIB
  • 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
  • Crizotinib impurity A
  • Crizotinib S-Isomer
  • Crizotinib Impurity 24
  • 3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
  • Crizotinib, (S)-
  • ent-crizotinib
  • CRIZOTINIB CHIRAL IMPURITY
  • (s)-g-fitinib
  • mutT,inhibit,nucleotide,Apoptosis,(S) crizotinib,homologue,Inhibitor,activity,anticancer,pool,(S)-Crizotinib,(S)crizotinib,DNA/RNA Synthesis
  • CRIZOTINIB, S-ENANTIOMER
  • 1374356-45-2
  • Inhibitors