ChemicalBook > CAS DataBase List > 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-

Product Name
2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
CAS No.
1374356-45-2
Chemical Name
2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
Synonyms
(s)-g-fitinib;(S)-CRIZOTINIB;ent-crizotinib;Crizotinib, (S)-;Crizotinib S-Isomer;Crizotinib impurity A;Crizotinib Impurity 24;CRIZOTINIB, S-ENANTIOMER;CRIZOTINIB CHIRAL IMPURITY;3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
CBNumber
CB12729650
Molecular Formula
C21H22Cl2FN5O
Formula Weight
450.34
MOL File
1374356-45-2.mol
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2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Property

Boiling point:
599.2±50.0 °C(Predicted)
Density 
1.47±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 5 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 0.5 mg/ml; Ethanol: 0.5 mg/ml
form 
A solid
pka
9.81±0.10(Predicted)
color 
Light yellow to yellow
CAS DataBase Reference
1374356-45-2
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
6025
Product name
(S)-Crizotinib
Purity
≥98%(HPLC)
Packaging
10
Price
$137
Updated
2021/12/16
Tocris
Product number
6025
Product name
(S)-Crizotinib
Purity
≥98%(HPLC)
Packaging
50
Price
$578
Updated
2021/12/16
TRC
Product number
C785005
Product name
(S)-Crizotinib
Packaging
5mg
Price
$275
Updated
2021/12/16
TRC
Product number
C785005
Product name
(S)-Crizotinib
Packaging
2.5mg
Price
$180
Updated
2021/12/16
TRC
Product number
C785005
Product name
(S)-Crizotinib
Packaging
1mg
Price
$80
Updated
2021/12/16
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2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Chemical Properties,Usage,Production

Characteristics

MTH1 (NUDT1)-selective inhibitor.

Uses

(S)-Crizotinib is the S-isomer of Crizotinib (C785000) and a novel potent, selective, and cell permeable MTH1 inhibitor. (S)-Crizotinib can also serve as a promising anticancer agent.

Definition

ChEBI: Ent-crizotinib is a 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that is the (S)-enantiomer of crizotinib. It is an enantiomer of a crizotinib.

Biological Activity

(S)-crizotinib, (S)enantiomer-crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.

target

TargetValue
MTH1
(Cell-free assay)		 72 nM

storage

Store at RT

2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Suppliers

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View Lastest Price from 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- manufacturers

Career Henan Chemical Co
Product
2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- 1374356-45-2
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200g
Release date
2020-02-01

1374356-45-2, 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-Related Search:

Lead Selenium Diethyl sulfate LEUHISTIN Angeli’s Salt Lignosulfonic acid Everolimus KU-55933 (ATM Kinase Inhibitor) Sunitinib Malate Crizotinib TH588 AZD-9291

  • (S)-CRIZOTINIB
  • 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
  • Crizotinib impurity A
  • Crizotinib S-Isomer
  • Crizotinib Impurity 24
  • 3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
  • Crizotinib, (S)-
  • ent-crizotinib
  • CRIZOTINIB CHIRAL IMPURITY
  • (s)-g-fitinib
  • mutT,inhibit,nucleotide,Apoptosis,(S) crizotinib,homologue,Inhibitor,activity,anticancer,pool,(S)-Crizotinib,(S)crizotinib,DNA/RNA Synthesis
  • CRIZOTINIB, S-ENANTIOMER
  • 1374356-45-2
  • Inhibitors