ChemicalBook > CAS DataBase List > 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
- Product Name
- 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
- CAS No.
- 1374356-45-2
- Chemical Name
- 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-
- Synonyms
- (s)-g-fitinib;(S)-CRIZOTINIB;ent-crizotinib;Crizotinib, (S)-;Crizotinib S-Isomer;Crizotinib impurity A;Crizotinib Impurity 24;CRIZOTINIB, S-ENANTIOMER;CRIZOTINIB CHIRAL IMPURITY;3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
- CBNumber
- CB12729650
- Molecular Formula
- C21H22Cl2FN5O
- Formula Weight
- 450.34
- MOL File
- 1374356-45-2.mol
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2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Property
- Boiling point:
- 599.2±50.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 5 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 0.5 mg/ml; Ethanol: 0.5 mg/ml
- form
- A solid
- pka
- 9.81±0.10(Predicted)
- CAS DataBase Reference
- 1374356-45-2
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N-Bromosuccinimide Price
Tocris
- Product number
- 6025
- Product name
- (S)-Crizotinib
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $137
- Updated
- 2021/12/16
Tocris
- Product number
- 6025
- Product name
- (S)-Crizotinib
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $578
- Updated
- 2021/12/16
TRC
- Product number
- C785005
- Product name
- (S)-Crizotinib
- Packaging
- 5mg
- Price
- $275
- Updated
- 2021/12/16
TRC
- Product number
- C785005
- Product name
- (S)-Crizotinib
- Packaging
- 2.5mg
- Price
- $180
- Updated
- 2021/12/16
TRC
- Product number
- C785005
- Product name
- (S)-Crizotinib
- Packaging
- 1mg
- Price
- $80
- Updated
- 2021/12/16
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2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Chemical Properties,Usage,Production
Characteristics
MTH1 (NUDT1)-selective inhibitor.
Uses
(S)-Crizotinib is the S-isomer of Crizotinib (C785000) and a novel potent, selective, and cell permeable MTH1 inhibitor. (S)-Crizotinib can also serve as a promising anticancer agent.
Definition
ChEBI: Ent-crizotinib is a 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine that is the (S)-enantiomer of crizotinib. It is an enantiomer of a crizotinib.
Biological Activity
(S)-crizotinib, (S)enantiomer-crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.
target
| Target | Value |
| MTH1 (Cell-free assay) | 72 nM |
storage
Store at RT
2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Suppliers
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View Lastest Price from 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- manufacturers
Career Henan Chemical Co
- Product
- 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- 1374356-45-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200g
- Release date
- 2020-02-01
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