ChemicalBook > CAS DataBase List > 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide

3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide

Product Name
3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide
CAS No.
1164153-22-3
Chemical Name
3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide
Synonyms
SR-3576;JNK3 Inhibitor XII;SR-3576 >=98% (HPLC);JNK3 Inhibitor XII, SR-3576;JNK3 Inhibitor XII, SR-3576 - CAS 1164153-22-3 - Calbiochem;3-[4-(3-m-Tolyl-ureido)-pyrazol-1-yl]-N-(3,4,5-trimethoxy-phenyl)-benzamide;3-(5-(3-m-Tolylureido)-1H-indazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide;3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide;Benzamide, 3-[4-[[[(3-methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-
CBNumber
CB12750449
Molecular Formula
C27H27N5O5
Formula Weight
501.53
MOL File
1164153-22-3.mol
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3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide Property

Boiling point:
557.7±50.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥20mg/mL
form 
powder
pka
11.51±0.70(Predicted)
color 
light brown to brown
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
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Safety

WGK Germany 
3
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
420143
Product name
JNK3 Inhibitor XII, SR-3576
Packaging
5mg
Price
$159
Updated
2024/03/01
Tocris
Product number
5044
Product name
SR3576
Purity
≥97%(HPLC)
Packaging
10
Price
$183
Updated
2021/12/16
Tocris
Product number
5044
Product name
SR3576
Purity
≥97%(HPLC)
Packaging
50
Price
$753
Updated
2021/12/16
Usbiological
Product number
256745
Product name
SR 3576
Packaging
10mg
Price
$466
Updated
2021/12/16
TRC
Product number
S684518
Product name
SR3576
Packaging
10mg
Price
$195
Updated
2021/12/16
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3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide Chemical Properties,Usage,Production

Description

SR-3576 (1164153-22-3) is a potent and selective JNK3 inhibitor. IC50?= 7nM and >2800-fold selective over p38.1?Cell permeable.

Uses

SR 3576 is a JNK-3 selective inhibitor.

General Description

A cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC50 = 7 nM), inhibiting JNK1 only at much higher concentrations (IC50 = 170 nM) and exhibiting little activity against p38 even at concentrations as high as 20 μM. Shown to inhibit streptozotocin- (Cat. No. 572201) induced c-jun phosphorylation in INS-1 rat β-pancreatic cells (IC50 = 1.3 μM).

Biochem/physiol Actions

SR-3576 is a small molecule inhibitor belonging to aminopyrazole class that selectively inhibits JNK3 with >2800 fold selectively over p38.1

storage

Store at -20°C

References

1) Kamenecka?et al. (2009),?Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38; J. Biol. Chem.,?284?12853

3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide Suppliers

China 27 India 1 United Kingdom 1 United States 10 USA 1 Global 40
Sigma-Aldrich
Tel
021-61415566 800-8193336
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orderCN@merckgroup.com
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China
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Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
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021-65675885
Email
info@efebio.com
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China
ProdList
9709
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
Email
sales@chemegen.com
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China
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11289
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Energy Chemical
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021-58432009 400-005-6266
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021-58436166
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marketing1@energy-chemical.com
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China
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MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
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order@med-bio.cn
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China
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8141
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Changzhou Furuisi Biotechnology Co., Ltd
Tel
0519-85524369
Email
3477467573@qq.com
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China
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8618
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TargetMol Chemicals Inc.
Tel
4008200310
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marketing@tsbiochem.com
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China
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24131
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Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
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sales@chemhifuture.com
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China
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4030
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Aladdin Scientific
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+1-833-552-7181
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sales@aladdinsci.com
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United States
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52927
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1164153-22-3, 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamideRelated Search:

CHK2 INHIBITOR II TYRPHOSTIN AG 1296 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- SU 4312

  • 3-(5-(3-m-Tolylureido)-1H-indazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide
  • JNK3 Inhibitor XII, SR-3576 - CAS 1164153-22-3 - Calbiochem
  • SR-3576
  • JNK3 Inhibitor XII, SR-3576
  • 3-[4-(3-m-Tolyl-ureido)-pyrazol-1-yl]-N-(3,4,5-trimethoxy-phenyl)-benzamide
  • 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide
  • JNK3 Inhibitor XII
  • SR-3576 >=98% (HPLC)
  • Benzamide, 3-[4-[[[(3-methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-
  • 1164153-22-3