5-IODOTUBERCIDIN

ChemicalBook > CAS DataBase List > 5-IODOTUBERCIDIN

Product Name: 5-IODOTUBERCIDIN
CAS No.: 24386-93-4
Chemical Name: 5-IODOTUBERCIDIN
Synonyms: ITU;5-ITu;CS-824;NSC 113939;IODOTUBERCIDIN;7-I-7-Deaza-Ar;5-IODOTUBERCIDIN;5-IODOTUBERICIDIN;Iodotubercidin,Itu;5-Iodo-Tubercidine
CBNumber: CB1280221
Molecular Formula: C11H13IN4O4
Formula Weight: 392.15
MOL File: 24386-93-4.mol

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5-IODOTUBERCIDIN Property

Melting point:: 216-217°C dec.
Boiling point:: 701.5±60.0 °C(Predicted)
Density: 2.49±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: 0.1 M HCl: 0.7 mg/mL
form: solid
pka: 12.33±0.70(Predicted)
color: tan
Stability:: Store tightly sealed at 4°C; Light Sensitive
InChIKey: WHSIXKUPQCKWBY-IOSLPCCCSA-N
CAS DataBase Reference: 24386-93-4

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Safety

WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I100
Product name: 5-Iodotubericidin
Purity: ≥90%, solid
Packaging: 5mg
Price: $683
Updated: 2024/03/01

Sigma-Aldrich

Product number: I100
Product name: 5-Iodotubericidin
Purity: ≥90%, solid
Packaging: 25mg
Price: $2670
Updated: 2024/03/01

Cayman Chemical

Product number: 10010375
Product name: 5-Iodotubercidin
Purity: ≥95%
Packaging: 500 μg
Price: $56
Updated: 2024/03/01

Cayman Chemical

Product number: 10010375
Product name: 5-Iodotubercidin
Purity: ≥95%
Packaging: 100μg
Price: $15
Updated: 2022/04/27

Cayman Chemical

Product number: 10010375
Product name: 5-Iodotubercidin
Purity: ≥95%
Packaging: 250μg
Price: $32
Updated: 2022/04/27

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5-IODOTUBERCIDIN Chemical Properties,Usage,Production

Chemical Properties

Tan Solid

Uses

An analogue of the antibiotic tubercidin, a pyrrolo[2,3-d]pyrimidine nucleoside antibiotic. A potent inhibitor of adenosine kinase from rat or guinea pig brain. Inhibits uptake of 3H-adenosine into brain slices.

Uses

A potent and competitive inhibitor of ERK2, PKA, and ADK.

Uses

5-Iodotubercidin has been used for the inhibition of retinoblastoma cells, astroglial cultures and for the inhibition of adenosine kinase in human umbilical vein endothelial cells (HUVECs).

General Description

solubility: 10 mg/mL in DMSO

Biological Activity

Potent adenosine kinase inhibitor (IC 50 = 26 nM) and nucleoside transporter inhibitor (IC 50 values are 7, 15 and < 25 nM for inhibition of [ 3 H]-uridine, [ 3 H]-formycin B and [ 3 H]-adenosine uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC 50 values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μ M respectively).

Biochem/physiol Actions

Potent inhibitor of adenosine uptake into brain, and of adenosine kinase and subsequent metabolism of adenine nucleotides. In cultured rat hepatocytes, 5-iodotubercidin inhibits both acetyl-CoA carboxylase and de novo synthesis of fatty acids and cholesterol.

storage

Store at -20°C

References

[1]. xin zhang, deyong jia, huijuan liu, et al. identification of 5-iodotubercidin as a genotoxic drug with anti-cancer potential. plos one, 2013, 8(5):e62527.
[2]. jaoek park and radhey s. gupta. adenosine: a key link between metabolism and brain activity: adenosine metabolism, adenosine kinase, and evolution. new york: springer science+business media, 2013.
[3]. garcía-villafranca j. and castro j. effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-coa carboxylase. biochem. pharmacol., 2002, 63(11):1997-2000.
[4]. haiyan chen, ji-ping wang, richard j. santen, et al. adenosine monophosphate activated protein kinase (ampk), a mediator of estradiol-induced apoptosis in long-term estrogen deprived breast cancer cells. apoptosis, 2015, 20:821-830.

5-IODOTUBERCIDIN Preparation Products And Raw materials

Raw materials

Preparation Products

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5-IODOTUBERCIDIN Suppliers

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View Lastest Price from 5-IODOTUBERCIDIN manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 5-Iodotubercidin 24386-93-4
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 97%min
Supply Ability: 1000g
Release date: 2021-09-06

Yunbio Tech Co.,Ltd.

Product: 5-IODOTUBERCIDIN 24386-93-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%
Supply Ability: 200
Release date: 2019-08-08

Career Henan Chemical Co

Product: 5-IODOTUBERCIDIN 24386-93-4
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-08-05

24386-93-4, 5-IODOTUBERCIDINRelated Search:

PIERICIDIN A IODOTUBERCIDIN FROM RAT OR GUINEA PI 7-iodotubercidin 5'-deoxy-5-iodotubercidin 4-Amino-7H-pyrrolo[2,3-d]pyrimidine TUBERCIDIN DEAZAPURINE 7-DEAZA-2'-DEOXYADENOSINE 1-(2-HYDROXYETHYL)PYRROLE 1-(3-HYDROXYPROPYL)PYRROLE 5-IODOTUBERCIDIN

7-IODO-7-DEAZAADENOSINE

5-IODOTUBERCIDIN

5-IODOTUBERICIDIN

4-AMINO-5-IODO-7-(BETA-D-RIBOFURANOSYL)PYRROLO[2,3-D]PYRIMIDINE

IODOTUBERCIDIN

ITU

Iodotubercidin,Itu

4-Amino-5-iodo-7-(b-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

4-amino-5-iodo-7-(β-d-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

5-IODOTUBERCIDIN 98+%

iodotubercidin, 5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

7-Deaza-7-iodoadenosine

5-Iodotubercidin (or 7-Deaza-7-iodoadenosine)

3-d]pyriMidin-7-yl)-tetrahydro-5-(hydroxyMethyl)furan-3

5R)-2-(4-aMino-5-iodo-7H-pyrrolo[2

NSC 113939

5-ITu

7H-Pyrrolo[2,3-d]pyriMidin-4-aMine,5-iodo-7-b-D-ribofuranosyl-

4-Amino-5-iodo-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine

7-Iodo-7-deazaadenosine, 4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

(2R,3R,4S,5R)-2-(4-amino-5-iodo-5H-pyrrolo[2,3-d]pyrimidin-7(6H)-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

7-I-7-Deaza-Ar

(2S,3S,4R,5S)-2-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2

3-d]pyrimidin-4- amine

5-Iodo-Tubercidine

CS-824

2-{4-AMINO-5-IODOPYRROLO[2,3-D]PYRIMIDIN-7-YL}-5-(HYDROXYMETHYL)OXOLANE-3,4-DIOL

5-Iodotubercidin (NSC 113939)

7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 5-iodo-7-β-D-ribofuranosyl-

4-Amino-5-iodo-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine, 7-Iodo-tubercidin, 7-deaza-7-iodoadenosine

5-IODOTUBERCIDIN USP/EP/BP

(2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

7-Iodo-tubercidin,7-Deaza-7-iodoadenosine,Adenosine kinase inhibitor, Protein kinase inhibitor and activator, nucleoside transporters inhibitor

5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Iodotubercidin, adenosine kinase inhibitor

24386-93-4

C11H13IN4O4

Bases & Related Reagents

Inhibitors

Nucleotides

Protein Kinase Inhibitors and Activators

Miscellaneous Natural Products