ChemicalBook > CAS DataBase List > RO-31-7549

RO-31-7549

Product Name
RO-31-7549
CAS No.
125313-65-7
Chemical Name
RO-31-7549
Synonyms
RO-31-7549;RO 31-7549 ACETATE SALT;Bisindolylmaleimide VIII;BISINDOLYLMALEIMIDE VIII ACETATE;BIDINDOLYLMALEIMIDE VIII, ACETETE;Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem;2-[1-3(AMINOPROPYL)INDOL-3-YL]-3(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, ACETATE;3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(1-(3-aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-
CBNumber
CB1281637
Molecular Formula
C24H22N4O2
Formula Weight
398.46
MOL File
125313-65-7.mol
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RO-31-7549 Property

storage temp. 
−20°C
solubility 
DMSO: soluble
form 
Red to reddish-orange solid
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
557508
Product name
Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem<br />A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC.
Packaging
1mg
Price
$216
Updated
2024/03/01
Usbiological
Product number
044608
Product name
Bisindolylmaleimide VIII acetate
Packaging
1mg
Price
$286
Updated
2021/12/16
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RO-31-7549 Chemical Properties,Usage,Production

Uses

It is a potent inhibitor of protein kinase C (PKC) activity.

General Description

A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cγ1. Exhibits some degree of PKC isozyme specificity (IC50 = 53 nM for PKCα, 195 nM for PKCβI, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε). Inhibits carbachol-evoked noradrenaline release (IC50 = 600 nM).

Biochem/physiol Actions

Cell permeable: yes

RO-31-7549 Preparation Products And Raw materials

Raw materials

Preparation Products

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RO-31-7549 Suppliers

Canada 1 China 27 Japan 2 Switzerland 3 United Kingdom 2 United States 5 Global 40
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
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60
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
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80
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
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58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44806
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
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58
Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel
+86-057181025280; +8617767106207
Fax
0571-85806285
Email
sales@molcore.com
Country
China
ProdList
49734
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58

125313-65-7, RO-31-7549Related Search:

Bisindolylmaleimide V RO 31-7549, IMMOBILIZED RO 31-7549 ACETATE 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione 3-Isopropenyl-1-methyl-1H-pyrrole RO-31-7549

  • BISINDOLYLMALEIMIDE VIII ACETATE
  • 1H-Pyrrole-2,5-dione, 3-(1-(3-aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-
  • 3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
  • Bisindolylmaleimide VIII
  • 2-[1-3(AMINOPROPYL)INDOL-3-YL]-3(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, ACETATE
  • RO-31-7549
  • RO 31-7549 ACETATE SALT
  • BIDINDOLYLMALEIMIDE VIII, ACETETE
  • Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem
  • 125313-65-7
  • C24H22N4O2C2H4O2
  • Amines
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Protein Kinase Inhibitors and Activators