ChemicalBook > CAS DataBase List > RO-31-7549
RO-31-7549
- Product Name
- RO-31-7549
- CAS No.
- 125313-65-7
- Chemical Name
- RO-31-7549
- Synonyms
- RO-31-7549;RO 31-7549 ACETATE SALT;Bisindolylmaleimide VIII;BISINDOLYLMALEIMIDE VIII ACETATE;BIDINDOLYLMALEIMIDE VIII, ACETETE;Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem;2-[1-3(AMINOPROPYL)INDOL-3-YL]-3(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, ACETATE;3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(1-(3-aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-
- CBNumber
- CB1281637
- Molecular Formula
- C24H22N4O2
- Formula Weight
- 398.46
- MOL File
- 125313-65-7.mol
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RO-31-7549 Property
- storage temp.
- −20°C
- solubility
- DMSO: soluble
- form
- Red to reddish-orange solid
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 557508
- Product name
- Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem<br />A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC.
- Packaging
- 1mg
- Price
- $216
- Updated
- 2024/03/01
Usbiological
- Product number
- 044608
- Product name
- Bisindolylmaleimide VIII acetate
- Packaging
- 1mg
- Price
- $286
- Updated
- 2021/12/16
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RO-31-7549 Chemical Properties,Usage,Production
Uses
It is a potent inhibitor of protein kinase C (PKC) activity.
General Description
A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cγ1. Exhibits some degree of PKC isozyme specificity (IC50 = 53 nM for PKCα, 195 nM for PKCβI, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε). Inhibits carbachol-evoked noradrenaline release (IC50 = 600 nM).
Biochem/physiol Actions
Cell permeable: yes
RO-31-7549 Preparation Products And Raw materials
Raw materials
Preparation Products
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125313-65-7, RO-31-7549Related Search:
Bisindolylmaleimide V
RO 31-7549, IMMOBILIZED
RO 31-7549 ACETATE
3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione
3-Isopropenyl-1-methyl-1H-pyrrole
RO-31-7549