ChemicalBook > CAS DataBase List > Bisindolylmaleimide VIII acetate salt

Bisindolylmaleimide VIII acetate salt

Product Name
Bisindolylmaleimide VIII acetate salt
CAS No.
138516-31-1
Chemical Name
Bisindolylmaleimide VIII acetate salt
Synonyms
Bis VIII acetate;RO 31-7549 ACETATE;BISINDOLYLMALEIMIDE VIII ACETATE SALT;BisindolylMaleiMide VIII . AcOH [Ro 31-7549];3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione acetate;3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione monoacetate;1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-, acetate (1:1);protein,Bisindolylmaleimide VIII acetate,Ro 31-7549,Inhibitor,inhibit,Fas,Bis VIII,Apoptosis,autoimmune,Protein kinase C,diseases,kinase,cell-mediated,Bisindolylmaleimide VIII,PKC
CBNumber
CB32130296
Molecular Formula
C24H22N4O2
Formula Weight
398.464
MOL File
138516-31-1.mol
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Bisindolylmaleimide VIII acetate salt Property

storage temp. 
-20°C
solubility 
Soluble in DMSO
form 
Red powder.
color 
Brown to reddish brown
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Safety

HS Code 
2925199590
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13333
Product name
Bisindolylmaleimide VIII (acetate)
Purity
≥98%
Packaging
1mg
Price
$50
Updated
2024/03/01
Cayman Chemical
Product number
13333
Product name
Bisindolylmaleimide VIII (acetate)
Purity
≥98%
Packaging
5mg
Price
$183
Updated
2024/03/01
Cayman Chemical
Product number
13333
Product name
Bisindolylmaleimide VIII (acetate)
Purity
≥98%
Packaging
10mg
Price
$341
Updated
2024/03/01
TRC
Product number
B448500
Product name
BisindolylmaleimideVIIIAceticAcidSalt
Packaging
10mg
Price
$175
Updated
2021/12/16
Adipogen Life Sciences
Product number
AG-CR1-0114-M001
Product name
BisindolylmaleimideVIII.acetate
Purity
≥98%(NMR)
Packaging
1mg
Price
$45
Updated
2021/12/16
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Bisindolylmaleimide VIII acetate salt Chemical Properties,Usage,Production

Uses

It is a potent inhibitor of protein kinase C (PKC) activity. Bisindolylmaleimide VIII (Bis VIII) has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism.

Biological Activity

bisindolylmaleimide viii is a protein kinase c (pkc) inhibitor.the protein kinase c (pkc) consists of a family of closely related isoenzymes mediating various signal transduction processes. the ten isoenzymes that have been currently identified can be divided into three families on the basis of their different requirements for activation. members of the conventional pkc family are ca2+ and phospholipid-dependent and are activated by diacylglycerols and phorbol esters.

in vitro

previous study found that bisindolylmaleimides carrying a straight-chain alkyl side-chain bearing a cationic substituent, such as ro 31-7549 (bisindolylmaleimide viii) and ro 31-8220, showed a significant improvement in potency over the simple bisindolylmaleimides. for bisindolylmaleimide viii, a further improvement in potency was obtained by restricting the position of the amine substituent. moreove, unlike the indolocarbazole, staurosporine, which displayed 2-fold selectivity for pkc-β over the other examined isoenzymes, bisindolylmaleimide viii exhibited a slight selectivity for pkc-α over the other isoenzymes. compounds such as bisindolylmaleimide viii carrying a straight-chain alkyl side-chain with the cationic substituent were found to be equipotent as inhibitors of pkc-β, pkc-γ and pkc-ε [1].

in vivo

animal study found that, in neonatal rats, high glucose levels could induce the hypertrophy of cardiomyocytes. ro-31-8220, a analog of bisindolylmaleimide viii, was able to reverse the effect of high glucose on the cardiac myocytes,which might be through pkc/nf-κb/c-fos pathway [2].

IC 50

158 nm for rat brain pkc

References

[1] wilkinson, s. e.,parker, p.j. and nixon, j.s. isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase c. biochemistry journal 294, 335-337 (1993).
[2] zhang, w. b. et al. reverse effect of protein kinase c inhibitor ro-31-8220 on the hypertrophy of cardiomyocytes of neonatal rats induced by high glucose levels. chinese journal of pathophysiology. 2009-08.

Bisindolylmaleimide VIII acetate salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Bisindolylmaleimide VIII acetate salt Suppliers

J & K SCIENTIFIC LTD.
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138516-31-1, Bisindolylmaleimide VIII acetate saltRelated Search:


  • BisindolylMaleiMide VIII . AcOH [Ro 31-7549]
  • BISINDOLYLMALEIMIDE VIII ACETATE SALT
  • RO 31-7549 ACETATE
  • 3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione monoacetate
  • Bis VIII acetate
  • 1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-, acetate (1:1)
  • protein,Bisindolylmaleimide VIII acetate,Ro 31-7549,Inhibitor,inhibit,Fas,Bis VIII,Apoptosis,autoimmune,Protein kinase C,diseases,kinase,cell-mediated,Bisindolylmaleimide VIII,PKC
  • 3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione acetate
  • 138516-31-1
  • inhibitor