Bisindolylmaleimide V

Product Name: Bisindolylmaleimide V
CAS No.: 113963-68-1
Chemical Name: Bisindolylmaleimide V
Synonyms: RO 31-6045;BISINDOLYLMALEIMIDE V;Sotrastaurin Impurity 12;n-methylbis(indol-3-yl)maleimide;BisindolylMaleiMide V [Ro 31-6045];1-METHYL-3,4-BIS(3-INDOLYL)MALEIMIDE;1-METHYL-3,4-BIS(INDOL-3-YL)MALEIMIDE;2,3-Di(1H-Indol-3-yl)-N-methylmaleimide;2,3-BIS(1H-INDOL-3-YL)-N-METHYLMALEIMIDE;3,4-Di-1H-indol-3-yl-1-methyl-1H-pyrrole-2,5-dione
CBNumber: CB6329851
Molecular Formula: C21H15N3O2
Formula Weight: 341.36
MOL File: 113963-68-1.mol

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Bisindolylmaleimide V Property

Melting point:: >260 °C
Boiling point:: 655.7±55.0 °C(Predicted)
Density: 1.450±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO: soluble
form: solid
pka: 15.89±0.30(Predicted)
color: Orange
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
CAS DataBase Reference: 113963-68-1(CAS DataBase Reference)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 203303
Product name: Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem
Purity: A cell-permeable negative control compound for protein kinase C inhibition studies (IC?? >100 μM).
Packaging: 400μG
Price: $68.9
Updated: 2023/01/07

Sigma-Aldrich

Product number: 203303
Product name: Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem
Packaging: 1mg
Price: $223
Updated: 2023/01/07

TCI Chemical

Product number: B6143
Product name: Bisindolylmaleimide V
Packaging: 10MG
Price: $127
Updated: 2025/07/31

TCI Chemical

Product number: B6143
Product name: Bisindolylmaleimide V
Packaging: 50MG
Price: $383
Updated: 2025/07/31

Cayman Chemical

Product number: 13300
Product name: Bisindolylmaleimide V
Purity: ≥98%
Packaging: 1mg
Price: $64
Updated: 2024/03/01

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Bisindolylmaleimide V Chemical Properties,Usage,Production

Description

Ro 31-6045 (113963-68-1) is a bis indolylmaleimide derivative that is a potent inhibitor of the mitogen-stimulated protein kinase p70 (S6K) acting independently of its upstream activator mTOR.1?Does not inhibit PKC (at concentrations <100?mM) and therefore may be used as a negative control for bisindolylmaleimide PKC inhibitors2?such as GF 109203X3?and other structurally related inhibitors4.

Uses

Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies with an IC50 value over 100 μM[1]. Bisindolylmaleimide V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 of 8 μM[2].

Definition

ChEBI: Ro 31-6045 is a member of indoles.

References

[1] NELLY MARMY-CONUS Richard B P Katherine M Hannan. Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70s6k/p85s6k: implications for the analysis of S6K signalling[J]. FEBS Letters, 2002, 519 1-3: 135-140. DOI:10.1016/s0014-5793(02)02738-2
[2] C S HARMON. Bisindolylmaleimide protein-kinase-C inhibitors delay the decline in DNA synthesis in mouse hair follicle organ cultures.[J]. Skin pharmacology : the official journal of the Skin Pharmacology Society, 1997, 10 2: 71-78. DOI:10.1159/000211471
[3] D. TOULLEC. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.[J]. The Journal of Biological Chemistry, 1991, 12 1: 15771-15781. DOI:10.1016/s0021-9258(18)98476-0
[4] PETER D. DAVIS. Inhibitors of protein kinase C. 1. 2,3-bisarylmaleimides[J]. Journal of Medicinal Chemistry, 1992, 35 1: 177-184. DOI:10.1021/jm00079a024

Bisindolylmaleimide V Preparation Products And Raw materials

Raw materials

Preparation Products

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Bisindolylmaleimide V Suppliers

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113963-68-1, Bisindolylmaleimide VRelated Search:

Succinimide 2-Methylindole Kresoxim-methyl N-Ethylmaleimide N-Phenylmaleimide N-Benzylmaleimide Pyrrole Methyl salicylate Methyl acetate Maleimide Tribenuron methyl O-Phthalimide METSULFURON METHYL Bismaleimide Thiophanate-methyl Methyl Polyamideimide DIALIFOS

1-Methyl-3,4-bis(indol-3-yl)maleimide, Ro 31-6045

1-Methyl 3,4-bis(1H-indole-3-yl)-3-pyrroline-2,5-dione

1-Methyl-3-(1H-indole-3-yl)-4-(1H-indole-3-yl)-1H-pyrrole-2,5-dione

1-Methyl-3,4-bis(1H-indole-3-yl)-3-pyrroline-2,5-dione

3,4-Bis(1H-indol-3-yl)-1-methyl-1H-pyrrole-2,5-dione

3,4-Bis(1H-indole-3-yl)-1-methyl-3-pyrroline-2,5-dione

Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem

BISINDOLYLMALEIMIDE V

3,4-Di-1H-indol-3-yl-1-methyl-1H-pyrrole-2,5-dione

BisindolylMaleiMide V [Ro 31-6045]

bisindolylmaleimide v:1-methyl-3,4-bis(3-indolyl)maleimide

RO 31-6045

2,3-BIS(1H-INDOL-3-YL)-N-METHYLMALEIMIDE

1-METHYL-3,4-BIS(3-INDOLYL)MALEIMIDE

1-METHYL-3,4-BIS(INDOL-3-YL)MALEIMIDE

3,4-BIS-(1H-INDOL-3-YL)-1-METHYL-PYRROLE-2,5-DIONE

n-methylbis(indol-3-yl)maleimide

1H-Pyrrole-2,5-dione, 3,4-di-1H-indol-3-yl-1-methyl-

2,3-Di(1H-Indol-3-yl)-N-methylmaleimide

Bisindolylmaleimide V,inhibit,Ribosomal S6 Kinase (RSK),Inhibitor,BIM V,S6K

3,4-bis(1H-indol-3-yl)-1-methyl-2,5-dihydro-1H-pyrrole-2,5-dione

Sotrastaurin Impurity 12

113963-68-1

C21H15N3O2

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Protein Kinase Inhibitors

Protein Phosphorylation