ChemicalBook > CAS DataBase List > RO-31-7549

RO-31-7549

Product Name
RO-31-7549
CAS No.
125313-65-7
Chemical Name
RO-31-7549
Synonyms
RO-31-7549;RO 31-7549 ACETATE SALT;Bisindolylmaleimide VIII;BISINDOLYLMALEIMIDE VIII ACETATE;BIDINDOLYLMALEIMIDE VIII, ACETETE;Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem;2-[1-3(AMINOPROPYL)INDOL-3-YL]-3(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, ACETATE;3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(1-(3-aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-
CBNumber
CB1281637
Molecular Formula
C24H22N4O2
Formula Weight
398.46
MOL File
125313-65-7.mol
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RO-31-7549 Property

storage temp. 
−20°C
solubility 
DMSO: soluble
form 
Red to reddish-orange solid
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
557508
Product name
Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem<br />A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC.
Packaging
1mg
Price
$216
Updated
2024/03/01
Usbiological
Product number
044608
Product name
Bisindolylmaleimide VIII acetate
Packaging
1mg
Price
$286
Updated
2021/12/16
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RO-31-7549 Chemical Properties,Usage,Production

Uses

It is a potent inhibitor of protein kinase C (PKC) activity.

General Description

A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cγ1. Exhibits some degree of PKC isozyme specificity (IC50 = 53 nM for PKCα, 195 nM for PKCβI, 163 nM for PKCβII, 213 nM for PKCγ, and 175 nM for PKCε). Inhibits carbachol-evoked noradrenaline release (IC50 = 600 nM).

Biochem/physiol Actions

Cell permeable: yes

RO-31-7549 Preparation Products And Raw materials

Raw materials

Preparation Products

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RO-31-7549 Suppliers

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125313-65-7, RO-31-7549Related Search:

Bisindolylmaleimide V RO 31-7549, IMMOBILIZED RO 31-7549 ACETATE 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione 3-Isopropenyl-1-methyl-1H-pyrrole RO-31-7549

  • BISINDOLYLMALEIMIDE VIII ACETATE
  • 1H-Pyrrole-2,5-dione, 3-(1-(3-aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-
  • 3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
  • Bisindolylmaleimide VIII
  • 2-[1-3(AMINOPROPYL)INDOL-3-YL]-3(1-METHYL-1H-INDOL-3-YL)MALEIMIDE, ACETATE
  • RO-31-7549
  • RO 31-7549 ACETATE SALT
  • BIDINDOLYLMALEIMIDE VIII, ACETETE
  • Ro-31-7549, Monohydrate - CAS 125313-65-7 - Calbiochem
  • 125313-65-7
  • C24H22N4O2C2H4O2
  • Amines
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Protein Kinase Inhibitors and Activators