Raloxifene

Application in Particular Diseases

Product Name: Raloxifene
CAS No.: 84449-90-1
Chemical Name: Raloxifene
Synonyms: RALOXIFEN;Evista;RALOXAFINE;RALOXIFENE;RALOXIFENE-D7;Raloxifene CRS;LY156758 free base;Raloxifene USP/EP/BP;Raloxifene hydrochlo;99% Purity Raloxifene
CBNumber: CB1290431
Molecular Formula: C28H27NO4S
Formula Weight: 473.58
MOL File: 84449-90-1.mol

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Raloxifene Property

Melting point:: 250-253°C
Boiling point:: 728.2±60.0 °C(Predicted)
Density: 1.289±0.06 g/cm3(Predicted)
storage temp.: Desiccate at +4°C
solubility: DMSO: 28 mg/mL, soluble
pka: 8.83±0.15(Predicted)
form: solid
color: light yellow
Water Solubility: 560μg/L at 25℃
LogP: 6.09
CAS DataBase Reference: 84449-90-1(CAS DataBase Reference)

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Safety

WGK Germany: 3
HS Code: 29349990
Hazardous Substances Data: 84449-90-1(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H311Toxic in contact with skin

H360May damage fertility or the unborn child

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: R099995
Product name: Raloxifene
Packaging: 100mg
Price: $75
Updated: 2021/12/16

TRC

Product number: R099995
Product name: Raloxifene
Packaging: 1g
Price: $105
Updated: 2021/12/16

Usbiological

Product number: 464501
Product name: Raloxifene
Packaging: 100mg
Price: $355
Updated: 2021/12/16

TRC

Product number: R099995
Product name: Raloxifene
Packaging: 5g
Price: $470
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003075
Product name: KEOXIFENE
Purity: 95.00%
Packaging: 50MG
Price: $164.85
Updated: 2021/12/16

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Raloxifene Chemical Properties,Usage,Production

Application in Particular Diseases

In Osteoporosis:

Raloxifene is an estrogen agonist on bone but an antagonist on the breast and uterus. It is approved for prevention and treatment of postmenopausal osteoporosis. Other estrogen agonists/antagonists may be approved soon (e.g., bazedoxifene, lasofoxifene).
Raloxifene decreases vertebral fractures and increases spine and hip BMD, but to a lesser extent than bisphosphonates. After discontinuation, the beneficial effect is lost and bone loss returns to age- or disease-related rates.
Raloxifene (like tamoxifen) is associated with decreased breast cancer risk. Raloxifene is associated with decreases in total and low-density lipoprotein cholesterol, neutral effects on high-density lipoprotein cholesterol, but slight increases in triglycerides; no beneficial cardiovascular effects have yet been demonstrated.
Raloxifene is well tolerated overall. Hot flushes occur more frequently in women recently finishing menopause or discontinuing estrogen therapy (ET). Endometrial bleeding occurs rarely. Raloxifene is contraindicated in women with an active or past history of venous thromboembolism. Therapy should be stopped if a patient anticipates extended immobility.

Chemical Properties

Light-Yellow Solid

Uses

A nonsteroidal estrogen receptor mixed agonist/antagonist

Uses

Raloxifene is a nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.

Indications

Raloxifene (Evista) is a new SERM approved for use in the treatment and prevention of osteoporosis because it has estrogenic activity in bone. Raloxifene is an estrogen antagonist in both breast and endometrial tissues. The estrogenlike properties of raloxifene result in the maintenance of a favorable serum lipid profile (decreased low-density lipoprotein levels with no change in either high-density lipoproteins or triglycerides). Raloxifene is 95% bound to plasma proteins. Absorption of raloxifene is impaired by cholestyramine.

Definition

ChEBI: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.

brand name

Evista (Lilly).

General Description

Raloxifene, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone (Evista), is a benzothiophene derivativethat differs slightly from the triphenylethyleneSERMs. A key structural difference is the carbonyl “hinge”that connects the modified phenolic side chain to the benzothiophenering system. This hinge is the key structural elementthat leads to the differing actions at the ERs.Raloxifene, unlike tamoxifen and toremifene, has antagonistproperties on the endometrium and breast tissue and agonistproperties on bone and the cardiovascular system. The lackof agonist action on endometrial tissue has been suggestedas a reason for the lack of endometrial cancer associatedwith raloxifene use. Raloxifene is approved for the preventionand treatment of osteoporosis in postmenopausalwomen. It has also been investigated for preventing breastcancer in comparison with tamoxifen. Recent studies indicatesthat it has similar effectiveness to tamoxifen, but has apreferable side effect profile.

Biological Activity

Selective estrogen receptor modulator (SERM) that binds to ER α and ER β , and tissue-dependently activates or blocks estrogen-induced transcription. Acts as an antiestrogen in breast and uterine tissue, but displays estrogen agonist activity in bone. In D12 rat hypothalamic cells, inhibits progesterone receptor induction by estrogen with an IC 50 of 1 nM.

Clinical Use

Raloxifene, the first SERM approved for the prevention of osteoporosis in postmenopausal women, acts as an estrogen agonist on receptors in osteoblasts and osteoclasts but as an antagonist at breast and uterine estrogen receptors.

Raloxifene Preparation Products And Raw materials

Raw materials

Thianaphthene Biphenyl 2-Bromo-4'-methoxyacetophenone Phenetole Methanesulfonyl chloride Esterified product

Preparation Products

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Raloxifene Suppliers

Canada 1 China 121 France 1 Germany 1 India 8 United Kingdom 8 United States 21 Global 161

LGM Pharma

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View Lastest Price from Raloxifene manufacturers

Wuhan Nutra Biotechnology Co.,Ltd

Product: Raloxifene 84449-90-1
Price: US $10.00-0.00/g
Min. Order: 1g
Purity: 98%+
Supply Ability: 100kgs
Release date: 2021-05-27

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Raloxifene 84449-90-1
Price: US $1330.00/kg
Min. Order: 0.1kg
Purity: 99% min
Supply Ability: 20 tons
Release date: 2022-10-13

Anhui Ruihan Technology Co., Ltd

Product: Raloxifene 84449-90-1
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000t/year
Release date: 2023-09-06

84449-90-1, RaloxifeneRelated Search:

Droloxifene 4-Ethoxyphenol Benzo[b]thien-2-ylboronic acid CHLOROPHOSPHONAZO III DIETHOXYMETHANE acetic acid, triethoxy-, ethyl ester 2-Ethoxyphenol Ethoxyquin RALOXIFENE HCL,RALOXIFENE HYDROCHLORIDE 6-Methoxy-2-(4-methoxyphenyl)benzobithiophene RALOXIFENE-D4 Ethoxy Raloxifene 6'-glucuronide RALOXIFENE-D4 BISMETHYL ETHER RALOXIFENE-D4, HYDROCHLORIDE 6-HYDROXY-4'-TERT-BUTYLDIMETHYLSYLYL-RALOXIFENE-D4 Raloxifene 4'-glucuronide 6-METHOXY-2-(4-METHOXY PHENYL)-BENZO[B]THIEN-3-YL][4-[2-(1-[PIPERIDINYL)ETHOXY]PHENYL]METHANONE HYDROCHLORIDE

[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-y1][4-[2-(1-piperidinyl)ethoxy]phenyl]methamone

Evista

[4-[2-(1-Piperidinyl) Ethoxy] Phenyl]methanone.HCL

RALOXAFINE

[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone

[6-hydroxy-2-(4-hydroxyphenyl)benzothiophen-3-yl]-[4-[2-(1-piperidyl)ethoxy]phenyl]methanone hydrochloride

Methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-

[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl] ketone

[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone

2-(4-Hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene-6-ol

(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)Methanone

[6-Hydroxy-2-(4-hydroxyphenyl)benzothien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone

(6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methan

RALOXIFEN

RALOXIFENE

Raloxifene CRS

Raloxifene for peak identification CRS

Raloxifene USP/EP/BP

99% Purity Raloxifene

Raloxifene hydrochlo

RALOXIFENE-D7

Raloxifene (Evista, RAL) (65)-1 gram

LY156758 free base

84449-90-1

C28H28ClNO4S

C28H27NO4S

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Estrogen

Cytokines, Growth Factors and Hormones

Hormones

Steroid Hormones

Raloxifene

Intermediates & Fine Chemicals

Pharmaceuticals

Pharmaceutical intermediate