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2-(4-Fluorophenyl)-thiophene

Product Name
2-(4-Fluorophenyl)-thiophene
CAS No.
58861-48-6
Chemical Name
2-(4-Fluorophenyl)-thiophene
Synonyms
2-(4-FL;AKOS BAR-1344;Canagliflozin INT2;IFLAB-BB F2108-0130;Impurity of caglitazin;FLUOROPHENYL)THIOPHENE;Cagliflozin Impurity 14;2-(4-Fluorphenyl)thiophen;2-(4-fluorophenyl)thiophen;Canagliflozin intermediate
CBNumber
CB1294813
Molecular Formula
C10H7FS
Formula Weight
178.23
MOL File
58861-48-6.mol
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2-(4-Fluorophenyl)-thiophene Property

Melting point:
51.0 to 55.0 °C
Boiling point:
252.3±15.0 °C(Predicted)
Density 
1.200±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
soluble in Methanol
form 
powder to crystal
color 
Light orange to Yellow to Green
InChI
InChI=1S/C10H7FS/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h1-7H
InChIKey
PURJRGMZIKXDMW-UHFFFAOYSA-N
SMILES
C1(C2=CC=C(F)C=C2)SC=CC=1
CAS DataBase Reference
58861-48-6
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
F0724
Product name
2-(4-Fluorophenyl)thiophene
Purity
>95.0%(GC)
Packaging
1g
Price
$50
Updated
2024/03/01
TCI Chemical
Product number
F0724
Product name
2-(4-Fluorophenyl)thiophene
Purity
>95.0%(GC)
Packaging
5g
Price
$153
Updated
2024/03/01
TRC
Product number
F591560
Product name
2-(4-Fluorophenyl)-thiophene
Packaging
5g
Price
$1295
Updated
2021/12/16
Matrix Scientific
Product number
090403
Product name
2-(4-Fluorophenyl)thiophene
Purity
95+%
Packaging
5g
Price
$1418
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0010377
Product name
2-(4-FLUORO-PHENYL)-THIOPHENE
Purity
95.00%
Packaging
20G
Price
$1903
Updated
2021/12/16
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2-(4-Fluorophenyl)-thiophene Chemical Properties,Usage,Production

Chemical Properties

white solid

Uses

2-(4-Fluorophenyl)-thiophene can be used to prepare Canagliflozin (C175190) as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus.

Synthesis

4-fluorobenzoic boric acid and 2-bromothiophene, Pd catalyst are added in organic solvent and dissolves, obtain material 3, wherein: 4-fluorine Phenylboric acid molar concentration in organic solvent is 0.5mol/L～2mol/L, and 4-fluorobenzoic boric acid with the mol ratio of 2-bromothiophene is 1:1.0～1:1.5,4-fluorobenzoic boric acid is 1:0.005～1:0.1 with the mol ratio of catalyst；Using material 3 with as material 4 Inorganic base aqueous solution carries out pre-incubation respectively to being 1:1.0～1 according to the mol ratio of 4-fluorobenzoic boric acid Yu alkali after reaction temperature: The mode of 3.0 mixes, and reacts under conditions of 50 ℃～80 ℃, then carries out post processing and obtains 2-(4-fluorophenyl) Thiophene.

2-(4-Fluorophenyl)-thiophene Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-Fluorophenyl)-thiophene Suppliers

Americas 1 Canada 1 China 298 Europe 3 France 1 Germany 3 India 31 Japan 1 Russia 1 Slovakia 1 Switzerland 2 United Kingdom 4 United States 22 Global 369
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View Lastest Price from 2-(4-Fluorophenyl)-thiophene manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
2-(4-FLUOROPHENYL)THIOPHENE 58861-48-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2023-09-15
Hebei Guanlang Biotechnology Co., Ltd.
Product
2-(4-FLUOROPHENYL)THIOPHENE 58861-48-6
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2021-11-11
Nanjing Fred Technology Co., Ltd
Product
2-(p-Fluorophenyl)thiophene 58861-48-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2024-01-02

58861-48-6, 2-(4-Fluorophenyl)-thiopheneRelated Search:

3-AMINO-2-CYANO-5-(4-FLUOROPHENYL)THIOPHENE,3-AMINO-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBONITRILE METHYL 3-AMINO-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXYLATE DUP-697 Ethyl 2-amino-4-(4-fluorophenyl)thiophene-3-carboxylate ,98% 3-AMINO-2-CYANO-5-(4-FLUOROPHENYL)THIOPHENE,3-AMINO-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBONITRILE 3-AMINO-5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXAMIDE 5-(4-FLUOROPHENYL)THIOPHENE-2-CARBOXYLI& 6-(4-FLUOROPHENYL)-3,4-DIHYDROTHIENO[3,2-D]-PYRIMIDIN-4-ONE METHYL 5-(4-FLUOROPHENYL)-2-THIOPHENECARBOXYLATE 4-CHLORO-6-(4-FLUOROPHENYL)THIENO[3,2-D]PYRIMIDINE Methyl 2-[(chloroacetyl)amino]-4-(4-fluorophenyl)-thiophene-3-carboxylate 2-Amino-N-(2-fluorophenyl)thiophene-3-carboxamide Isopropyl 2-amino-4-(4-fluorophenyl)thiophene-3-carboxylate N-(5-amino-2-fluorophenyl)thiophene-2-sulfonamide 5-(3-fluorophenyl)thiophene-2-carboxylic acid methyl 2-[(cyanoacetyl)amino]-4-(4-fluorophenyl)thiophene-3-carboxylate ethyl 2-amino-4-(3-fluorophenyl)thiophene-3-carboxylate N-(3-amino-4-fluorophenyl)thiophene-2-carboxamide

  • IFLAB-BB F2108-0130
  • 2-(4-FLUOROPHENYL)THIOPHENE
  • AKOS BAR-1344
  • Thiophene, 2-(4-fluorophenyl)-
  • Canagliflozin intermediate
  • Canagliflozin Intermediate I
  • Canagliflozin INT2
  • 2-(4-fluorophenyl)thiophen
  • Canagliflozin Related Impurity 14
  • Cagliflozin Impurity 14
  • 2-(4-Fluorophenyl)thiophene&gt
  • 2-(4-FL
  • Impurity of caglitazin
  • 2-(4-FLUOROPHENYL)THIOPHENE 58861-48-6
  • 2-(4-FLUOROPHENYL)THIOPHENE ISO 9001：2015 REACH
  • 2-(4-Fluorphenyl)thiophen
  • 2-(p-Fluorophenyl)thiophene
  • FLUOROPHENYL)THIOPHENE
  • 58861-48-6
  • 58861-48-6