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Nebivolol

Product Name
Nebivolol
CAS No.
99200-09-6
Chemical Name
Nebivolol
Synonyms
R-65824;Nebivolol;Nibivolol;NEBIVOLOL-D4;NEBIVOLOL-D6;(Rac)-Nebivolol;Nebilolol impurity 11;Nebivolol (10mM in DMSO);rac-Nebivolol (Mixture of Diastereomers);2,2'-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol)
CBNumber
CB1295698
Molecular Formula
C22H25F2NO4
Formula Weight
405.43
MOL File
99200-09-6.mol
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Nebivolol Property

Boiling point:
600.5±55.0 °C(Predicted)
Density 
1.309±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
14.29±0.20(Predicted)
color 
White to Off-White
InChI
InChI=1/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2/t17-,18-,21-,22+/s3/i11D2,12D2
InChIKey
KOHIRBRYDXPAMZ-AWIIVWKDNA-N
SMILES
C([2H])([2H])([C@H](O)[C@@]1([H])CCC2C=C(C=CC=2O1)F)NC([2H])([2H])[C@H](O)[C@]1([H])CCC2C=C(C=CC=2O1)F |&1:3,5,21,23,r|
CAS DataBase Reference
99200-09-6(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
N387933
Product name
Nebivolol
Packaging
10mg
Price
$180
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
ND34423
Product name
(S,R,R,R)-Nebivolol-d2,15Nhydrochloride
Packaging
5mg
Price
$1690
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0031361
Product name
NEBIVOLOL
Purity
95.00%
Packaging
100G
Price
$5699.93
Updated
2021/12/16
Ambeed
Product number
A753261
Product name
2,2'-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol)
Purity
98%
Packaging
100mg
Price
$93
Updated
2021/12/16
Ambeed
Product number
A753261
Product name
2,2'-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol)
Purity
98%
Packaging
250mg
Price
$170
Updated
2021/12/16
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Nebivolol Chemical Properties,Usage,Production

Description

Nebilet was launched in Germany and the Netherlands as an antihypertensive agent. It is prepared by a five step route starting with 6-fluoro-4- oxobenzopyran-2-carboxylic acid. It is a selective β1-adrenergic receptor antagonist and is 50 times less potent at β2-receptors. Vasodialating properties occur via the nitric oxide pathway. While the L-isomer is more potent than the D-isomer, the racemic mixture is necessary for optimal activity. Upon administration, an immediate fall in blood pressure occurs, it improves both left ventricular systolic and diastolic function, and lowers peripheral blood resistance. Nebilet does not influence insulin sensitivity nor lipid profile comparible to atenolol. Doses of 50 mg of atenolol and 10 mg of Nebilet are equipotent but Nebilet has a longer duration of action due to an accumulation of the drug and increasing plasma levels of active metabolites.

Originator

Johnson & Johnson (US)

Uses

Nebivolol is a cardioselective beta-1 receptor blocking agent.

Uses

Labeled Nebivolol, intended for use as an internal standard for the quantification of Nebivolol by GC- or LC-mass spectrometry.

Definition

ChEBI: A member of the class of chromanes that is 2,2'-iminodiethanol in which one hydrogen attached to each hydroxy-bearing carbon is replaced by a 6-fluorochroman-2-yl group.

brand name

Nebilet

Nebivolol Preparation Products And Raw materials

Raw materials

Preparation Products

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Nebivolol Suppliers

Canada 3 China 132 Europe 2 Germany 1 India 24 Russia 1 United Kingdom 6 United States 21 Global 190
Leancare Ltd.
Tel
--
Fax
--
Email
enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
Advantage
42
CARBONE SCIENTIFIC CO.,LTD
Tel
--
Fax
--
Email
sales@carbonesci.com
Country
United Kingdom
ProdList
6666
Advantage
30
Eurolabs Limited
Tel
--
Fax
--
Country
United Kingdom
ProdList
6309
Advantage
46
ETA SCIENTIFIC Co.,Ltd
Tel
--
Fax
--
Email
sales@etascientific.com
Country
United Kingdom
ProdList
6090
Advantage
34
UK GREEN SCIENTIFIC CO.,LIMITED
Tel
--
Fax
--
Email
sales@gs-chem.com
Country
United Kingdom
ProdList
6098
Advantage
47
Sequoia Research Products Ltd.
Tel
--
Fax
--
Email
sales@seqchem.com
Country
United Kingdom
ProdList
3113
Advantage
69
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View Lastest Price from Nebivolol manufacturers

Zhejiang J&C Biological Technology Co.,Limited
Product
nebivolol 99200-09-6
Price
US $0.00/gram
Min. Order
1gram
Purity
99%
Supply Ability
10kg
Release date
2022-02-17
Zhuozhou Wenxi import and Export Co., Ltd
Product
Nebivolol 99200-09-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Longyan Tianhua Biological Technology Co., Ltd
Product
Nebivolol 99200-09-6
Price
US $21.00/Kg/Bag
Min. Order
25Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2020-11-09

99200-09-6, NebivololRelated Search:

Propanolol Ethanol Atenolol 1-Hydroxyethylidene-1,1-diphosphonic acid N,N-Diisopropylethylamine Ethyl acrylate Ethylparaben Ethyl cellulose Diethylenetriamine Metoprolol CHLOROPHOSPHONAZO III 2-(2-Aminoethylamino)ethanol Ethyl acetate Esmolol Bisoprolol Diethyltoluenediamine Ethylbenzene Diethyl ether

  • NEBIVOLOL-D4
  • 1-(6-fluorochroman-2-yl)-2-[[2-(6-fluorochroman-2-yl)-2-hydroxy-ethyl]amino]ethanol
  • Nibivolol
  • Nebivolol Impurity 6(rac-Nebivolol (Mixture of Diastereomers))
  • 2,2'-azanediylbis(1-(6-fluorochroman-2-yl)ethan-1-ol)
  • rac-Nebivolol (Mixture of Diastereomers)
  • 1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl]amino]ethanol
  • R-65824
  • α,α'-(Iminobismethylene)bis(6-fluoro-2-chromanmethanol)
  • 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol]
  • Nebivolol
  • 1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol
  • 1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxy-ethyl]amino]ethanol
  • (1R)-1-[(2S)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-{[(2R)-2-[(2S)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-hydroxyethyl]aMino}ethan-1-ol
  • 2H-1-Benzopyran-2-methanol, α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-
  • Nebivolol (10mM in DMSO)
  • (Rac)-Nebivolol
  • 2,2'-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol)
  • NEBIVOLOL-D6
  • Rac-NebivololQ: What is Rac-Nebivolol Q: What is the CAS Number of Rac-Nebivolol Q: What is the storage condition of Rac-Nebivolol Q: What are the applications of Rac-Nebivolol
  • 2,2'-azanediylbis(1-(6-fluorochroman-2-yl)ethan-1-ol)
  • (RS)-1-((RS)-6-fluorochroman-2-yl)-2-(((RS)-2-((SR)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethanol
  • Nebilolol impurity 11
  • 99200-09-6
  • C22H25F2NO4
  • C22H21F2NO4D4
  • Antihypertensive