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Faropenem sodium hemipentahydrate

Product Name
Faropenem sodium hemipentahydrate
CAS No.
106560-14-9
Chemical Name
Faropenem sodium hemipentahydrate
Synonyms
FROPENEM;FAROPENEM;Faropenem sodium hemi 5-hydrate;Faropenem sodium hemipentahydrate;Faropenem sodium hemipentahydrate USP/EP/BP;6α-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid;(5R,6S,8R,2'R)-2-(2'-tetrahydrofuryl)-6-(1-hydroxyethyl)-2-penem-3-carboxylic acid;6alpha-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid;(5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-2-oxolanyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;(5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-oxolan-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
CBNumber
CB1300660
Molecular Formula
C12H15NO5S
Formula Weight
285.32
MOL File
106560-14-9.mol
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Faropenem sodium hemipentahydrate Property

Boiling point:
570.2±50.0 °C(Predicted)
Density 
1.56±0.1 g/cm3(Predicted)
pka
4.00±0.40(Predicted)
CAS DataBase Reference
106560-14-9
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
F103303
Product name
Faropenem
Packaging
100mg
Price
$580
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002771
Product name
FROPENEM
Purity
95.00%
Packaging
5G
Price
$927.76
Updated
2021/12/16
AHH
Product number
API-1035
Product name
Fropenem
Purity
98%
Packaging
100mg
Price
$600
Updated
2021/12/16
AvaChem
Product number
1723A
Product name
Faropenem
Packaging
10mg
Price
$39
Updated
2021/12/16
AvaChem
Product number
1723A
Product name
Faropenem
Packaging
100mg
Price
$89
Updated
2021/12/16
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Faropenem sodium hemipentahydrate Chemical Properties,Usage,Production

Description

Farom was launched in Japan for use as an antibiotic against common respiratory tract pathogens. It can be prepared by several related routes of about seven steps starting with tetrahydrofuran-2-thiocarboxylic acid and a silylated azetidinone. It is a broad spectrum oral penem antibiotic that is β-lactamase stable. Farom is the most active β-lactam against anaerobes (more than cefaclor, cefixime and amoxicillin) but also has activity against Gram-positive, Gram-negative and enterobacteriaceae. It is equally active against strains carrying plasmid and chromosome mediated β-lactamases. The short plasma elimination half-life is the result of hydrolysis by renal dehydropeptidase. It is more stable to hydrolysis by extended spectrum β-lactamases than some second and third generation cephalosporins.

Originator

Suntory (Japan)

Uses

Faropenem (cas# 106560-14-9) is a compound useful in organic synthesis.

Uses

Treatmentof bacterial infections.

Definition

ChEBI: 6alpha-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid is a faropenem. It is a conjugate acid of a 6alpha-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylate.

brand name

Farom

Antimicrobial activity

An orally active penem with a broad spectrum of antibacterial activity, including activity against selected anaerobic pathogens. Although it is active against most enterobacteria, it has reduced activity against Ser. marcescens, Enterobacter spp. and some Providencia spp. It generally retains activity against many Gram-positive organisms, but has no useful activity against Ps. aeruginosa. It has reduced activity against E. faecium, methicillin-resistant Staph. aureus (MRSA) and some strains of coagulase-negative staphylococci. It is stable to hydrolysis by extended spectrum β-lactamases, but is hydrolyzed by carbapenemases. Esterified prodrugs with increased bioavailability have been studied in clinical trials but have not received regulatory approval.

Faropenem sodium hemipentahydrate Preparation Products And Raw materials

Raw materials

TRIPHENYLMETHYL MERCAPTAN Triethyl phosphate Silver nitrate N,N-Diisopropylethylamine Tetrabutylammonium periodate Oxalyl chloride Chloromethane

Preparation Products

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Faropenem sodium hemipentahydrate Suppliers

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View Lastest Price from Faropenem sodium hemipentahydrate manufacturers

Career Henan Chemical Co
Product
Faropenem sodium hemipentahydrate 106560-14-9
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100KG
Release date
2018-12-17

106560-14-9, Faropenem sodium hemipentahydrateRelated Search:

Sodium bicarbonate Furazolidone Diclofenac sodium 5-Chlorovaleric acid Tetrahydrofuran Sodium hydroxide Sodium citrate Diphenolic acid Sodium acetate Sodium benzoate DL-α-Tocopherol Sodium chlorite Pralmorelin 2-(METHYLSULFONYL)ETHANOL Sodium chloride Sodium sulfate Ethyl maltol Sodium percarbonate

  • (+)-(5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • (5R,6S,8R,2'R)-2-(2'-tetrahydrofuryl)-6-(1-hydroxyethyl)-2-penem-3-carboxylic acid
  • 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-, [5R-[3(R*),5α,6α(R*)]]-
  • 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-, (5R,6S)-
  • 6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monosodium salt hemipentahydrate
  • Faropenem sodium hemipentahydrate
  • FAROPENEM
  • FROPENEM
  • [5R-[3(R^<*>^)，5α，6α(R^<*>^)]]-6-(1-hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-4-thia-1-azobicyclo[3.2.0]leapt-2- ene-2-carboxylicacid
  • (5R,6R)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydrofuran-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-2-oxolanyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-keto-3-[(2R)-tetrahydrofuran-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-oxolan-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • 6alpha-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid
  • 6α-[(R)-1-hydroxyethyl]-2-[(R)-tetrahydrofuran-2-yl]pen-2-em-3-carboxylic acid
  • Faropenem sodium hemipentahydrate USP/EP/BP
  • (5R,6S)-6-((R)-1-Hydroxyethyl)-7-oxo-3-((R)-tetrahydrofuran-2-yl)-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
  • Faropenem-d5Q: What is Faropenem-d5 Q: What is the CAS Number of Faropenem-d5 Q: What are the applications of Faropenem-d5
  • Faropenem sodium hemi 5-hydrate
  • 106560-14-9
  • 22547-49-3
  • 2C12H14NNaO5S5H20
  • 2C12H14NO5S2Na5H2O
  • API