2,2-Difluoropropionic acid

Uses Uses

Product Name: 2,2-Difluoropropionic acid
CAS No.: 373-96-6
Chemical Name: 2,2-Difluoropropionic acid
Synonyms: 2,2-Difluoropropanoic acid;2,2-DIFLUOROPROPIONIC ACID;Propanoic acid, 2,2-difluoro-;2,2-Difluoropropionic acid 97%
CBNumber: CB1301258
Molecular Formula: C3H4F2O2
Formula Weight: 110.06
MOL File: 373-96-6.mol

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2,2-Difluoropropionic acid Property

Melting point:: 38-45 °C
Boiling point:: 25-30 °C/5 mmHg
Density: 1.316±0.06 g/cm3(Predicted)
Flash point:: 25-30°C/5mm
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
pka: 1.34±0.10(Predicted)
color: White to Almost white
InChI: InChI=1S/C3H4F2O2/c1-3(4,5)2(6)7/h1H3,(H,6,7)
InChIKey: PMWGIVRHUIAIII-UHFFFAOYSA-N
SMILES: C(O)(=O)C(F)(F)C
CAS DataBase Reference: 373-96-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C
Risk Statements: 34-36
Safety Statements: 26-36/37/39
RIDADR: 3261
WGK Germany: 3
HazardClass: 8
PackingGroup: III
HS Code: 29159000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 684686
Product name: 2,2-Difluoropropionic acid
Purity: 97%
Packaging: 250mg
Price: $578.55
Updated: 2025/07/31

TCI Chemical

Product number: D5531
Product name: 2,2-Difluoropropionic Acid
Packaging: 1G
Price: $50
Updated: 2025/07/31

TRC

Product number: D455898
Product name: 2,2-Difluoropropionic Acid
Packaging: 500mg
Price: $60
Updated: 2021/12/16

TRC

Product number: D455898
Product name: 2,2-Difluoropropionic Acid
Packaging: 1g
Price: $75
Updated: 2021/12/16

TRC

Product number: D455898
Product name: 2,2-Difluoropropionic Acid
Packaging: 100mg
Price: $45
Updated: 2021/12/16

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2,2-Difluoropropionic acid Chemical Properties,Usage,Production

Uses

2,2-Difluoropropionic acid is a useful research chemical.

Uses

2,2-Difluoropropionic acid is mainly used in biochemical research.

Chemical Properties

White powder

Synthesis

28781-85-3

373-96-6

The general procedure for synthesizing 2,2-difluoropropionic acid from ethyl 2,2-difluoropropionate was as follows: referring to Example G38, ethyl 2,2-difluoropropionate (1.2 g, 8.8 mmol) was dissolved in ethanol (26 mL), followed by the slow addition of 2N aqueous sodium hydroxide solution (26 mL). The reaction mixture was stirred at 0 °C, then gradually warmed to room temperature and continued stirring for 14 hours. Upon completion of the reaction, the reaction mixture was acidified to pH < 7 with 2N hydrochloric acid and then extracted with ether. The organic phases were combined, dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure to give 2,2-difluoropropionic acid (0.90 g, 92% yield). The product was an oil with the following 1H-NMR (CDCl3) data: δ 1.85 (3H, t, J = 19.0 Hz), 6.21 (1H, br s).

References

[1] Patent: EP1402900, 2004, A1
[2] Patent: US2004/53973, 2004, A1
[3] Journal of Organic Chemistry USSR (English Translation), 1981, vol. 17, p. 1260 - 1263
[4] Zhurnal Organicheskoi Khimii, 1981, vol. 17, # 7, p. 1417 - 1420
[5] Journal of Organic Chemistry USSR (English Translation), 1982, vol. 18, p. 1597 - 1601

2,2-Difluoropropionic acid Preparation Products And Raw materials

Raw materials

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View Lastest Price from 2,2-Difluoropropionic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2,2-Difluoropropionic acid 373-96-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-22

Henan Aochuang Chemical Co.,Ltd.

Product: 2,2-Difluoropropionic acid 373-96-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2025-04-01

Zjartschem

Product: 2,2-Difluoropropionic acid 373-96-6
Price: US $0.00/kg
Min. Order: 100g
Purity: 97%
Supply Ability: 100kg
Release date: 2019-02-13

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2,2-DIFLUOROPROPIONIC ACID

2,2-Difluoropropanoic acid

2,2-Difluoropropionic acid 97%

Propanoic acid, 2,2-difluoro-

373-96-6

CH3CF2COOH

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