4-BROMOISATIN

Application

Product Name: 4-BROMOISATIN
CAS No.: 20780-72-7
Chemical Name: 4-BROMOISATIN
Synonyms: 4-BROM;4-Broisatin;4-BROMOISATIN;4-Bromoisatin 98%;BUTTPARK 50\07-93;4-Bromoisatin >4- broMoindigo carMine;Fampridine Impurity 25;4-BROMOINDOLE-2,3-DIONE;4-BROMOINDOLINE-2,3-DIONE
CBNumber: CB1301591
Molecular Formula: C8H4BrNO2
Formula Weight: 226.03
MOL File: 20780-72-7.mol

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4-BROMOISATIN Property

Melting point:: 253-256
Density: 1.826±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Dimethylformamide
form: powder to crystal
pka: 8.73±0.20(Predicted)
color: Light yellow to Brown
InChI: InChI=1S/C8H4BrNO2/c9-4-2-1-3-5-6(4)7(11)8(12)10-5/h1-3H,(H,10,11,12)
InChIKey: ITRAKBJPMLKWIW-UHFFFAOYSA-N
SMILES: N1C2=C(C(Br)=CC=C2)C(=O)C1=O
CAS DataBase Reference: 20780-72-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: B2423
Product name: 4-Bromoisatin
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: B2423
Product name: 4-Bromoisatin
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $116
Updated: 2025/07/31

TRC

Product number: B685523
Product name: 4-Bromoisatin
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

Chem-Impex

Product number: 44526
Product name: 4-Bromoisatin,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 5G
Price: $34.26
Updated: 2021/12/16

AK Scientific

Product number: J98505
Product name: 4-Bromo-1H-indole-2,3-dione
Packaging: 100g
Price: $130
Updated: 2021/12/16

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4-BROMOISATIN Chemical Properties,Usage,Production

Application

4-Bromoindigo is an organic bromide that can be used as an intermediate in pharmaceutical synthesis.

Definition

ChEBI: 4-Bromoisatin is a member of indoles. It has a role as an anticoronaviral agent.

Synthesis

65971-74-6

6326-79-0

20780-72-7

The general procedure for the synthesis of 6-bromodihydroindole-2,3-diones and 4-bromoindoline-2,3-diones using 2-hydroxyimino-N-(3-bromophenyl)-acetamide as starting material is as follows: 1. to a solution of hydrogen chloride (50.0 g, 0.247 mol) in water (237 mL) was sequentially added a mixture of anhydrous sodium sulfate (69.0 g, 0.486 mol) and 3-bromoaniline (40.0 g, 0.233 mol) in 37% hydrochloric acid (25 mL). 2. Water (632 mL) was added slowly with vigorous stirring. After addition, the reaction mixture was heated to reflux for 10 minutes and then cooled to room temperature. 3. The precipitate formed was collected by filtration, washed with water (3 x 100 mL) and dried under vacuum to give crude isonitrosoacetanilide. 4. The crude product was added in batches to rapidly stirred concentrated sulfuric acid (790 mL), with the rate of addition controlled to maintain the reaction temperature between 50 and 70 °C. The reaction was carried out in a controlled manner. 5. The reaction mixture was heated to 80°C, held for 20 minutes, and then cooled to room temperature. 6. The cooled mixture was poured into crushed ice (about 320 g) and allowed to stand for 1 hour. 7. The orange precipitate was collected by filtration, washed with water and dried to give a mixture of 4-bromoindigo (K-98) and 6-bromoindigo (K-99) (40 g, 83% yield).

References

[1] Patent: WO2006/44415, 2006, A2. Location in patent: Page/Page column 118
[2] Synthetic Communications, 2010, vol. 40, # 21, p. 3125 - 3134
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 4, p. 935 - 946
[4] Journal of Medicinal Chemistry, 2001, vol. 44, # 26, p. 4641 - 4649
[5] Journal of Medicinal Chemistry, 2010, vol. 53, # 1, p. 18 - 36

4-BROMOISATIN Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BROMOISATIN Suppliers

Americas 1 Belgium 1 China 185 Europe 1 India 9 Japan 4 Ukraine 1 United Kingdom 12 United States 34 Global 248

Carbosynth

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Key Organics Ltd.

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Molekula Limited

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Apollo Scientific Ltd

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Biosynth Carbosynth

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Manchester Organics

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Apollo Scientific Ltd.

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Leancare Ltd.

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MOLEKULA Ltd.

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Atlantic Research Chemicals Ltd.

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Eurolabs Limited

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Butt Park Ltd.

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View Lastest Price from 4-BROMOISATIN manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 4-Bromoisatin 20780-72-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-08-16

Henan Fengda Chemical Co., Ltd

Product: 4-BROMOISATIN 20780-72-7
Price: US $36.00-1.50/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-BROMOISATIN 20780-72-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

20780-72-7, 4-BROMOISATINRelated Search:

4-BROMO-5-FLUORO-7-METHYL ISATIN 4-BROMOISATIN 4-BROMO-7-METHYLISATIN 4-Bromo-5-methyl-2,3-indolinedione 6-Bromoisatinic anhydride 7-Bromoisatin 97% 5-BROMOISATIN, TECH., 90%,BromoIsatin,5-Bromoisatin,tech.90%,5-BROMOISATIN, 98+%,5-Bromoisatin, 90+%,5-BROMOISATIN,5-BROMOISATIN HEMIHYDRATE 6-Bromoisatin 97%,6-BROMOISATIN,BROMOISATIN(6-) Isatin 4-Bromoindole 4,6-DIBROMO ISATIN 4-BROMO-5-CHLOROINDOLINE-2,3-DIONE 4-Bromo-7-methoxyisatin 4-bromo-1-(2-bromoethyl)-2,3-dihydro-1H-indole-2,3-dione (4-bromo-2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetic acid 1-(3-amino-2-hydroxypropyl)-4-bromo-2,3-dihydro-1H-indole-2,3-dione 2-(4-bromo-2,3-dioxo-2,3-dihydro-1H-indol-1-yl)-N-methylacetamide N-BOC-4-BROMOISATIN

4-BROMO-1H-INDOLE-2,3-DIONE

4-BROMOINDOLE-2,3-DIONE

4-BROMOINDOLINE-2,3-DIONE

4-BROMOISATIN

BUTTPARK 50\07-93

4-Bromoisatin 98%

4-BROMO-2,3-INDOLINEDIONE 97.0%(MIN)(HPLC)

4-bromo-1H-indole-2,3-dione(SALTDATA: FREE)

4-broMo-2,3-dihydro-1H-indole-2,3-dione

4-Bromo-1H-indole-2,3-dione, 4-Bromoindolin-2,3-dione

4-Broisatin

4-BROM

4-BroMo isatin 4-BroMo indole-2,3-dione

4- broMoindigo carMine

4-Bromo-2,3-Indolinedione

4-Bromo-1H-indol-2,3-dione

4-Bromoisatin &gt

1H-Indole-2,3-dione, 4-bromo-

3-Isoxazolecarboxaldehyde,10-methyl-

Fampridine Impurity 25

20780-72-7

Simple Indoles

Indoles

Halides

Indoline & Oxindole

Indoles

Simple Indoles

Fused Ring Systems

K00001