ChemicalBook > CAS DataBase List > 2-FLUORO-6-METHOXYANILINE

2-FLUORO-6-METHOXYANILINE

Product Name
2-FLUORO-6-METHOXYANILINE
CAS No.
446-61-7
Chemical Name
2-FLUORO-6-METHOXYANILINE
Synonyms
-FLUORO-6-METHOXYANILINE;2-FLUORO-6-METHOXYANILINE;2-fluoro-6-methoxybenzenamine;2-Fluoro-6-methoxy-phenylamine;Benzenamine, 2-fluoro-6-methoxy-;2-Amino-3-fluoroanisole, 6-Fluoro-o-anisidine;2-AMino-3-fluoroanisole[2-Fluoro-6-Methoxyaniline]
CBNumber
CB1302174
Molecular Formula
C7H8FNO
Formula Weight
141.14
MOL File
446-61-7.mol
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2-FLUORO-6-METHOXYANILINE Property

Boiling point:
208 °C(Press: 756 Torr)
Density 
1.176±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
3.15±0.10(Predicted)
form 
slightly viscous liquid
color 
Clear, peach/khaki
InChI
InChI=1S/C7H8FNO/c1-10-6-4-2-3-5(8)7(6)9/h2-4H,9H2,1H3
InChIKey
VHHKZASLPJMWJI-UHFFFAOYSA-N
SMILES
C1(N)=C(OC)C=CC=C1F
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22
Hazard Note 
Irritant
HS Code 
2922290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
F592235
Product name
2-Fluoro-6-methoxyaniline
Packaging
250mg
Price
$65
Updated
2021/12/16
Matrix Scientific
Product number
089702
Product name
2-Fluoro-6-methoxyaniline
Purity
95+%
Packaging
1g
Price
$42
Updated
2021/12/16
Apolloscientific
Product number
PC0872
Product name
2-Fluoro-6-methoxyaniline
Packaging
250mg
Price
$51
Updated
2021/12/16
Apolloscientific
Product number
PC0872
Product name
2-Fluoro-6-methoxyaniline
Packaging
1g
Price
$61
Updated
2021/12/16
SynQuest Laboratories
Product number
4656-3-66
Product name
2-Fluoro-6-methoxyaniline
Purity
97%
Packaging
250mg
Price
$69
Updated
2021/12/16
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2-FLUORO-6-METHOXYANILINE Chemical Properties,Usage,Production

Chemical Properties

black liquid

Synthesis

641-49-6

446-61-7

General procedure for the synthesis of 2-fluoro-6-methoxyaniline using 3-fluoro-2-nitroanisole as starting material: 10% Pd/C catalyst (7.46 g, 70.1 mmol) and ethanol (400 mL) were added to a Parr reactor followed by 1-fluoro-3-methoxy-2-nitrobenzene (40.0 g, 234 mmol). The reactor was evacuated and filled with hydrogen (50 psi) and the reaction was shaken for 5 h under hydrogen atmosphere. After completion of the reaction, the catalyst was removed by Celite filtration and the filtrate was concentrated to give 2-fluoro-6-methoxyaniline (30.0 g, 83% yield) as a colorless oil. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 3.75 (broad single peak, 2H), 3.86 (single peak, 3H), 6.58-6.71 (multiple peaks, 3H); the molecular ion peak [M + H]+ = 142 was detected by LC-MS (LC-ES).

References

[1] Patent: WO2018/69863, 2018, A1. Location in patent: Page/Page column 248
[2] Journal of the American Chemical Society, 1932, vol. 54, p. 2973,2976
[3] Journal of the Chemical Society, 1931, p. 981
[4] Journal of Medicinal Chemistry, 1993, vol. 36, # 11, p. 1641 - 1653

2-FLUORO-6-METHOXYANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-FLUORO-6-METHOXYANILINE Suppliers

Canada 1 China 113 India 2 Italy 1 Ukraine 1 United Kingdom 4 United States 16 Global 138
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View Lastest Price from 2-FLUORO-6-METHOXYANILINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-FLUORO-6-METHOXYANILINE 446-61-7
Price
US $1.00-28.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20000KG
Release date
2024-07-29
Career Henan Chemical Co
Product
2-FLUORO-6-METHOXYANILINE 446-61-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

446-61-7, 2-FLUORO-6-METHOXYANILINERelated Search:

4-FLUORO-3-METHOXYANILINE,2-fluoro-5-aminoanisole(4-fluoro-3-methoxyaniline) 3-Fluoro-4-Methoxyaniline 2-Fluoro-4-Aminoanisole,3-FLUORO-4-METHOXYANILINE,3-Fluoro-4-methoxyaniline, 98+% 4-FLUORO-3-METHOXYANILINE HYDROCHLORIDE 4-Fluoro-2-methoxyaniline hydrochloride,4-Fluoro-2-methoxyaniline, HCl,4-Fluoro-2-methoxyaniline hydrochloride 98% 2-FLUORO-4-METHOXYANILINE 3-FLUORO-2-METHOXYANILINE 4-FLUORO-2-METHOXYANILINE 3-BROMO-5-FLUORO-4-METHOXYANILINE,3-Bromo-5-fluoro-4-methoxyaniline 98%,3-Bromo-5-fluoro-4-methoxyaniline98% 5-Fluoro-2-methoxyaniline hydrochloride N-Methyl 4-fluoro-2-methoxyaniline 2-FLUORO-4-METHOXYANILINE HYDROCHLORIDE,2-FLUORO-4-METHOXYANILINE, HCL 2-CHLORO-6-FLUORO-3-METHOXYANILINE 2-Bromo-4-fluoro-5-methoxyaniline 2-fluoro-5-methoxyaniline 3-FLUORO-4-METHOXYANILINE HYDROCHLORIDE 3-FLUORO-5-METHOXYANILINE 5-FLUORO-2-METHOXYANILINE 3-Fluoro-6-Methoxyaniline

  • 2-FLUORO-6-METHOXYANILINE
  • 2-fluoro-6-methoxybenzenamine
  • 2-Amino-3-fluoroanisole, 6-Fluoro-o-anisidine
  • 2-AMino-3-fluoroanisole[2-Fluoro-6-Methoxyaniline]
  • 2-Fluoro-6-methoxy-phenylamine
  • -FLUORO-6-METHOXYANILINE
  • Benzenamine, 2-fluoro-6-methoxy-
  • 446-61-7