3-Fluoro-4-methoxyaniline
- Product Name
- 3-Fluoro-4-methoxyaniline
- CAS No.
- 366-99-4
- Chemical Name
- 3-Fluoro-4-methoxyaniline
- Synonyms
- 3-FLUORO-4-ANISIDINE;3-FLUORO-P-ANISIDINE;3-Fluoro-4-methoxyan;4-Amino-2-fluoroanisol;4-AMINO-2-FLUOROANISOLE;3-FLUORO-4-METHOXYANILINE;3-Fluoro-p-anisidine;3-Fluoro-p-anisidine (NH2=1);3-Fluoro-4-methoxyaniline>3-Fluoro-4-methoxyaniline,99%
- CBNumber
- CB4208143
- Molecular Formula
- C7H8FNO
- Formula Weight
- 141.14
- MOL File
- 366-99-4.mol
3-Fluoro-4-methoxyaniline Property
- Melting point:
- 81-83 °C (lit.)
- Boiling point:
- 135 °C/18 mmHg (lit.)
- Density
- 1.1382 (estimate)
- Flash point:
- >110°C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 4.18±0.10(Predicted)
- form
- Crystalline Powder
- color
- Light beige to yellow-brown
- BRN
- 2717083
- InChI
- InChI=1S/C7H8FNO/c1-10-7-3-2-5(9)4-6(7)8/h2-4H,9H2,1H3
- InChIKey
- LJWAPDSCYTZUJU-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=C(OC)C(F)=C1
- CAS DataBase Reference
- 366-99-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi,T
- Risk Statements
- 20/21/22-36/37/38-23/24/25
- Safety Statements
- 26-37/39-45-38-36/37/39-28A
- RIDADR
- UN2811
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29214200
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 334871
- Product name
- 3-Fluoro-p-anisidine
- Purity
- 98%
- Packaging
- 5g
- Price
- $85
- Updated
- 2025/07/31
- Product number
- F0648
- Product name
- 3-Fluoro-4-methoxyaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $51
- Updated
- 2025/07/31
- Product number
- F0648
- Product name
- 3-Fluoro-4-methoxyaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $151
- Updated
- 2025/07/31
- Product number
- F593310
- Product name
- 3-Fluoro-4-methoxyaniline
- Packaging
- 5g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- F593310
- Product name
- 3-Fluoro-4-methoxyaniline
- Packaging
- 10g
- Price
- $140
- Updated
- 2021/12/16
3-Fluoro-4-methoxyaniline Chemical Properties,Usage,Production
Chemical Properties
light beige to yellow-brown crystalline powder
Uses
3-Fluoro-4-methoxyaniline was used as a reagent in the synthesis of novel leucine ureido derivatives which have potent inhibitory activity againt aminopeptidase N. Also used in the synthesis of novel mGluR1 antagonists for the treatment of chronic pain.
General Description
Arrhenius parameter has been measured for the reactions of 3-fluoro-p-anisidine (3-fluoro-4-methoxyaniline) with picryl chloride.
Synthesis
455-93-6
366-99-4
General procedure for the synthesis of 3-fluoro-4-methoxyaniline from 2-fluoro-4-nitroanisole: 3-fluoro-4-methoxynitrobenzene (0.5 g, 2.9 mmol) was dissolved in ethyl acetate (10 mL), a carbon-loaded palladium catalyst (50 mg) was added, and the reaction was stirred for 1 h at room temperature. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford the target product 3-fluoro-4-methoxyaniline (7B) as an off-white solid (0.4 g, 98% yield).
References
[1] Journal of Medicinal Chemistry, 2000, vol. 43, # 24, p. 4701 - 4710
[2] Patent: CN104395312, 2016, B. Location in patent: Paragraph 0640-0645
[3] Patent: US2006/128729, 2006, A1. Location in patent: Page/Page column 77
[4] Patent: WO2017/129796, 2017, A1. Location in patent: Page/Page column 251; 252
[5] Journal of the American Chemical Society, 1941, vol. 63, p. 609
3-Fluoro-4-methoxyaniline Preparation Products And Raw materials
Raw materials
Preparation Products
3-Fluoro-4-methoxyaniline Suppliers
- Tel
- 025-025-58742998 18136843696
- sales@deweichem.cn
- Country
- China
- ProdList
- 113
- Advantage
- 58
- Tel
- 0535-6385396
- Fax
- +86 (535) 638-9971
- info@carbottpharm.com
- Country
- China
- ProdList
- 957
- Advantage
- 56
- Tel
- 15672878902
- hnyingchuang@163.com
- Country
- China
- ProdList
- 3905
- Advantage
- 58
- Tel
- 13153019312
- 3977218233@qq.com
- Country
- China
- ProdList
- 39
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- +49 3493/605464
- Fax
- +49 3493/605470
- sales@intatrade.de
- Country
- Germany
- ProdList
- 3572
- Advantage
- 66
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
View Lastest Price from 3-Fluoro-4-methoxyaniline manufacturers
- Product
- 3-Fluoro-4-methoxyaniline 366-99-4
- Price
- US $786.00/Kg
- Min. Order
- 0.100Kg
- Purity
- 99 %
- Supply Ability
- 500 Kg
- Release date
- 2024-11-13
- Product
- 3-Fluoro-4-methoxyaniline 366-99-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20t
- Release date
- 2024-06-18
- Product
- 3-Fluoro-4-methoxyaniline 366-99-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.7%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18