ChemicalBook > CAS DataBase List > 3-Fluoro-4-methoxyaniline

3-Fluoro-4-methoxyaniline

Product Name
3-Fluoro-4-methoxyaniline
CAS No.
366-99-4
Chemical Name
3-Fluoro-4-methoxyaniline
Synonyms
3-FLUORO-4-ANISIDINE;3-FLUORO-P-ANISIDINE;3-Fluoro-4-methoxyan;4-Amino-2-fluoroanisol;4-AMINO-2-FLUOROANISOLE;3-FLUORO-4-METHOXYANILINE;3-Fluoro-p-anisidine;3-Fluoro-p-anisidine (NH2=1);3-Fluoro-4-methoxyaniline>3-Fluoro-4-methoxyaniline,99%
CBNumber
CB4208143
Molecular Formula
C7H8FNO
Formula Weight
141.14
MOL File
366-99-4.mol
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3-Fluoro-4-methoxyaniline Property

Melting point:
81-83 °C (lit.)
Boiling point:
135 °C/18 mmHg (lit.)
Density 
1.1382 (estimate)
Flash point:
>110°C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
4.18±0.10(Predicted)
form 
Crystalline Powder
color 
Light beige to yellow-brown
BRN 
2717083
InChI
InChI=1S/C7H8FNO/c1-10-7-3-2-5(9)4-6(7)8/h2-4H,9H2,1H3
InChIKey
LJWAPDSCYTZUJU-UHFFFAOYSA-N
SMILES
C1(N)=CC=C(OC)C(F)=C1
CAS DataBase Reference
366-99-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi,T
Risk Statements 
20/21/22-36/37/38-23/24/25
Safety Statements 
26-37/39-45-38-36/37/39-28A
RIDADR 
UN2811
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214200
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
334871
Product name
3-Fluoro-p-anisidine
Purity
98%
Packaging
5g
Price
$85
Updated
2025/07/31
TCI Chemical
Product number
F0648
Product name
3-Fluoro-4-methoxyaniline
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$51
Updated
2025/07/31
TCI Chemical
Product number
F0648
Product name
3-Fluoro-4-methoxyaniline
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$151
Updated
2025/07/31
TRC
Product number
F593310
Product name
3-Fluoro-4-methoxyaniline
Packaging
5g
Price
$85
Updated
2021/12/16
TRC
Product number
F593310
Product name
3-Fluoro-4-methoxyaniline
Packaging
10g
Price
$140
Updated
2021/12/16
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3-Fluoro-4-methoxyaniline Chemical Properties,Usage,Production

Chemical Properties

light beige to yellow-brown crystalline powder

Uses

3-Fluoro-4-methoxyaniline was used as a reagent in the synthesis of novel leucine ureido derivatives which have potent inhibitory activity againt aminopeptidase N. Also used in the synthesis of novel mGluR1 antagonists for the treatment of chronic pain.

General Description

Arrhenius parameter has been measured for the reactions of 3-fluoro-p-anisidine (3-fluoro-4-methoxyaniline) with picryl chloride.

Synthesis

455-93-6

366-99-4

General procedure for the synthesis of 3-fluoro-4-methoxyaniline from 2-fluoro-4-nitroanisole: 3-fluoro-4-methoxynitrobenzene (0.5 g, 2.9 mmol) was dissolved in ethyl acetate (10 mL), a carbon-loaded palladium catalyst (50 mg) was added, and the reaction was stirred for 1 h at room temperature. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford the target product 3-fluoro-4-methoxyaniline (7B) as an off-white solid (0.4 g, 98% yield).

References

[1] Journal of Medicinal Chemistry, 2000, vol. 43, # 24, p. 4701 - 4710
[2] Patent: CN104395312, 2016, B. Location in patent: Paragraph 0640-0645
[3] Patent: US2006/128729, 2006, A1. Location in patent: Page/Page column 77
[4] Patent: WO2017/129796, 2017, A1. Location in patent: Page/Page column 251; 252
[5] Journal of the American Chemical Society, 1941, vol. 63, p. 609

3-Fluoro-4-methoxyaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Fluoro-4-methoxyaniline Suppliers

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View Lastest Price from 3-Fluoro-4-methoxyaniline manufacturers

R&D Scientific Inc.
Product
3-Fluoro-4-methoxyaniline 366-99-4
Price
US $786.00/Kg
Min. Order
0.100Kg
Purity
99 %
Supply Ability
500 Kg
Release date
2024-11-13
Shaanxi Dideu Medichem Co. Ltd
Product
3-Fluoro-4-methoxyaniline 366-99-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20t
Release date
2024-06-18
Honest Joy Holdings Limited
Product
3-Fluoro-4-methoxyaniline 366-99-4
Price
US $0.00/KG
Min. Order
1KG
Purity
97.7%
Supply Ability
100 tons
Release date
2022-02-18

366-99-4, 3-Fluoro-4-methoxyanilineRelated Search:

3-Aminobenzotrifluoride 4-Fluoroaniline 3-Ethoxyaniline (Trifluoromethoxy)benzene 3-Fluoroaniline 2-Fluoroaniline 4-(Trifluoromethoxy)aniline p-Anisidine o-Anisidine Fluorine anisidine 4-METHOXY-3-NITROBENZOTRIFLUORIDE 4-FLUORO-2-METHOXYANILINE 4-Fluoro-2-methoxyaniline, HCl,4-Fluoro-2-methoxyaniline hydrochloride 98%,4-Fluoro-2-methoxyaniline hydrochloride 2-FLUORO-4-METHOXYANILINE 4-FLUORO-3-METHOXYANILINE HYDROCHLORIDE N-Methyl 4-fluoro-2-methoxyaniline 3-(2-FLUORO-4-NITROPHENOXY)-2-THIOPHENECARBOXYLIC ACID

  • 4-AMINO-2-FLUOROANISOLE
  • 3-Fluoro-p-anisidine (NH2=1)
  • 3-FLUORO-P-ANISIDINE
  • 3-FLUORO-4-ANISIDINE
  • 3-FLUORO-4-METHOXYANILINE
  • 3-Fluoro-4-Methoxyaniline 2-Fluoro-4-Aminoanisole
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  • 3-Fluoro-4-methoxy-phenylamine
  • 3-Fluoro-4-anisidine, 4-Amino-2-fluoroanisole
  • 3-Fluoro-4-Methoxyaniline, 99% 1GR
  • 4-Amino-2-fluoroanisole 3-Fluoro-p-anisidine 4-Amino-2-fluoro-1-methoxybenzene
  • 3-Fluoro-p-anisidine, 4-Amino-2-fluoroanisole
  • 4-AMino-2-fluoroanisole[3-Fluoro-4-Methoxyaniline]
  • 3-Fluoro-4-methoxyaniline, 98+%
  • 4-Amino-2-fluoro-1-methoxybenzene
  • 3-Fluoro-4-methoxyaniline,99%
  • 3-fluoro-4-methoxybenzenamine
  • Benzenamine, 3-fluoro-4-methoxy-
  • 3-Fluoro-4-methoxyaniline 3-Fluoro-p-anisidine
  • 3-Fluoro-4-methoxyan
  • 3-Fluoro-4-methoxyaniline&gt
  • 3-Fluoro-<i>p</i>-anisidine
  • 366-99-4
  • C7H8NOF
  • C7H8FNO
  • AMINE
  • Building Blocks
  • Amines
  • C7
  • Nitrogen Compounds
  • Organic Building Blocks
  • Anilines, Amides & Amines
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Fluorine Compounds
  • Aniline
  • Miscellaneous
  • Anilines, Aromatic Amines and Nitro Compounds
  • Other fluorin-contained compounds
  • bc0001