ChemicalBook > CAS DataBase List > 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride

1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride

Product Name
1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride
CAS No.
52605-52-4
Chemical Name
1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride
Synonyms
Trazodone Related CoMpound F;1-(3-CHLOROPHENY)-4-(3-CHLOROPROPYL) PIPERAZINE HYDROCHLORIDE;CCP HCL;Trazodone BP IMP F;Nefazodone USP RC A;Trazodone IMpurity F;LABOTEST-BB LT00138222;Trazodone EP Impurity F;Trazodone BP Impurity F;Chlorophenyl Hydrochloride
CBNumber
CB1303676
Molecular Formula
C13H19Cl3N2
Formula Weight
309.66
MOL File
52605-52-4.mol
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1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride Property

Melting point:
198-203 °C(lit.)
Boiling point:
147℃[at 101 325 Pa]
vapor pressure 
0Pa at 25℃
storage temp. 
2-8°C
solubility 
DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form 
powder to crystal
color 
White to Light yellow
Water Solubility 
3.9g/L at 28℃
InChI
InChI=1S/C13H18Cl2N2.ClH/c14-5-2-6-16-7-9-17(10-8-16)13-4-1-3-12(15)11-13;/h1,3-4,11H,2,5-10H2;1H
InChIKey
JVLRNANYLVRULL-UHFFFAOYSA-N
SMILES
ClC1=CC=CC(N2CCN(CCCCl)CC2)=C1.Cl
LogP
0.301 at 28℃
CAS DataBase Reference
52605-52-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-37/39-24/25
WGK Germany 
3
F 
10-21
HS Code 
2933599550
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3373
Product name
Trazodone Related Compound F
Purity
certified reference material, pharmaceutical secondary standard
Packaging
50MG
Price
$715
Updated
2025/07/31
Sigma-Aldrich
Product number
1673566
Product name
Trazodone Related Compound F
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1300
Updated
2025/07/31
Sigma-Aldrich
Product number
1457913
Product name
Nefazodone Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$697
Updated
2024/03/01
TCI Chemical
Product number
C1608
Product name
1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine Hydrochloride
Purity
>97.0%(HPLC)(T)
Packaging
25g
Price
$172
Updated
2025/07/31
Sigma-Aldrich
Product number
363464
Product name
1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochloride
Purity
97%
Packaging
25g
Price
$138.68
Updated
2025/07/31
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1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride is an arylpiperazine compound which is an important intermediate in the preparation of various pharmaceuticals, such as Trazodone (T718500), used to treat depression and post-traumatic stress.

General Description

1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochloride is present as impurity in nefazodone hydrochloride (pharmaceutical formulation). Synthesis of 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochloride is reported.

Flammability and Explosibility

Not classified

1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride Preparation Products And Raw materials

Raw materials

Acetone Diethanolamine Hydrochloric acid Sodium hydroxide 1-Bromo-3-chloropropane 3-Chloroaniline

Preparation Products

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1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride Suppliers

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View Lastest Price from 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride 52605-52-4
Price
US $2.00-5.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons
Release date
2025-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride 52605-52-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride 52605-52-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-03-05

52605-52-4, 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochlorideRelated Search:

Topotecan hydrochloride Piperazine Chlorodimethylphenylsilane Triphenylmethyl Chloride tert-Butylchlorodiphenylsilane Chloromethyl isopropyl carbonate 3-Chloropropyltrimethoxysilane Allyl chloride 3-Dechloro-3-broMo Trazodone Hydrochloride Trazodone Related CoMpound C Trazodone BP Impurity G Trazodone N-Oxide Dechloro Trazodone 2-[3-[4-(3-chloro-4-ethylphenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one Trazodone IMpurity H CHLOROPHENYLSILANE 1-(3-Chlorophenyl)piperazine dihydrochloride 3-DIETHYLAMINOPROPYL CHLORIDE

  • CCP HCL
  • LABOTEST-BB LT00138222
  • 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochlorid
  • Trazodone BP IMP F
  • Trazodone EP Impurity F
  • 1-(3-CHLOROPHENY)-4-(3-CHLOROPROPYL) PIPERAZINE HYDROCHLORIDE
  • 1-(3-CHLOROPHENYL)-4-(3-CHLOROPROPYL) PIPERAZINE HCL
  • 1-[4-(3-Chlorophenyl)piperazin-1-yl]-3-chloropropane Hydrochloride
  • 3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl Chloride Hydrochloride
  • Trazodone IMpurity F
  • Trazodone Related CoMpound F
  • Trazodone Related Compound F (25 mg) (1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride)
  • 1-(3-CHLOROPHENYL)-4-(3-CHLOROPROPYL)PIPERAZINE HYDROCHLORIDE
  • 1-(3-CHLOROPHENYL)-4-(3-CHLOROPROPYL)PIPERAZINE MONOHYDROCHLORIDE
  • 1-(3-CHLOROPROPYL)-4-(3-CHLOROPHENYL)PIPERAZINE HCL
  • 1-(3-Chloropropyl)-4-(3-Chlorophenyl) piperazine hydrochloride
  • 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazinium chloride
  • 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine hdyrochloride
  • 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride (CCP)
  • PIPERAZINE HYDROCHLORIDE( INTERMEDIATES FOR NEFAZODONE, ETOPERIDONE AND TRAZADONE)
  • 1-(3-Chlorophenyl)-4-(3-chloroproyl)piperazine hydrochloride
  • 1-(3-CHLOROPHENYL)-4-(3-CHLOROPROPYL)PIPERAZINE DIHYDROCHLORIDE
  • CHLOROPROPYL-4-(3-CHLOROPHENYL)PIPERAZINE
  • 1-(3-CHLOROPHENYL)-4-(3-CHLOROPROPYL)PIPERAZINE HYDROCHLORIDE 97+%
  • 1-(3-Chlorophenyl)-4-(3-Chloropropyl)piperizine Monohydrochloride
  • Trazodone BP Impurity F
  • 1-(3-Chloropropyl)-4-(3-chloropheny
  • 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine Hydrochloride &gt
  • Chlorophenyl Hydrochloride
  • Nefazodone USP RC A
  • Nefazodone Related Compound A/Trazodone RC F
  • Trazodone USP RC F / Nefazodone Related Compound A
  • l-(3-Chlorophenyl)-4-(3-chloropropyl) piperazine HCI
  • 1-(3-CHLOROPHENYL)-4-(3-CHLOROPROPYL)PIPERAZINE HCL (CCPH)
  • 1-(3-chlorophenyl)-4-(3-chloropropyl)-piperazine hydrochlori...
  • Trazodone Related Compound F(Secondary Standards traceble to USP)
  • Trazodone Related Compound F (1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride) (1673566)
  • Nefazodone Related Compound A as Hydrochloride
  • Trazodone Related Compound F as Hydrochloride
  • Nefazodone USP Related Compound A as Hydrochloride
  • Trazodone USP Related Compound F as Hydrochloride
  • Trazodone related compound F HCl
  • 2-[3-[4-(3-chlorophenyl)piperazin-1-yl propyl -[1,2,4 triazolo[4,3-a pyridin-3-one (TDZ3)
  • 1-(3-chlorophenyl)-4-(3-Chlorpropyl)piperidinHCL (TDZ2)
  • Trazodone Hydrochloride Impurity F as Hydrochloride
  • Trazodone Hydrochloride EP Impurity F as Hydrochloride
  • 1-(3-chlorophenyl)-4-(3-Chlorpropyl)piperidinHCL
  • 1-(3-Chlorophenyl)-4-(3-chlorophenyl) piperazine HCL
  • TRAZODONE USP RC F (SALT FREE)
  • Dimethoxy benzoic acid (DMBA)
  • Trazodone BP Impurity F HCl
  • 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride (1:1)
  • Trazodone EP Impurity F (as Hydrochloride)
  • 52605-52-4
  • C12H19Cl2N2HCl
  • C13H18Cl2N2ClH
  • Building Blocks
  • Heterocyclic Building Blocks