ChemicalBook > CAS DataBase List > ARV-825

ARV-825

Product Name: ARV-825
CAS No.: 1818885-28-7
Chemical Name: ARV-825
Synonyms: AVR-825;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]-2,3,9-trimethyl-, (6S)-;CS-2252;ARV-825;ARV-825 ，S8297;ARV-825;ARV 825;ARV825;ARV-825, 10 mM in DMSO;Epigenetic Reader Domain,inhibit,PROTACs,ARV 825,Inhibitor,ARV825,ARV-825;2-[(S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-[4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]acetamide;2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide
CBNumber: CB13041384
Molecular Formula: C46H47ClN8O9S
Formula Weight: 923.43
MOL File: 1818885-28-7.mol

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ARV-825 Property

Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO:5.0(Max Conc. mg/mL);5.41(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);5.41(Max Conc. mM)
Water:0.0(Max Conc. mg/mL);0.0(Max Conc. mM)
form: A crystalline solid
pka: 10.74±0.40(Predicted)
color: Light yellow to yellow

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3423
Product name: ARV-825
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $109
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3423
Product name: ARV-825
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $438
Updated: 2025/07/31

Cayman Chemical

Product number: 21109
Product name: ARV-825
Purity: ≥98%
Packaging: 500μg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 21109
Product name: ARV-825
Purity: ≥98%
Packaging: 1mg
Price: $92
Updated: 2024/03/01

Cayman Chemical

Product number: 21109
Product name: ARV-825
Purity: ≥98%
Packaging: 5mg
Price: $403
Updated: 2024/03/01

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ARV-825 Chemical Properties,Usage,Production

Description

ARV-825 is a PROTAC molecule composed of a BRD4 binding moiety joined to an E3 ligase cereblon binding moiety. ARV-825 recruits BRD4 to E3 ubiquitin ligase cereblon, resulting in the degradation of BRD4.

Uses

ARV-825 is a PROTAC connected by ligands for Cereblon and BRD4. ARV-825 binds to BD1 and BD2 of BRD4 with Kds of 90 and 28 nM, respectively.

Biological Activity

ARV-825 is a BRD4 inhibitor that recruits BRD4 to the E3 ubiquitin ligase cereblon, causing rapid, efficient and sustained degradation of BRD4 protein and sustained downregulation of MYC levels.

in vivo

In the mouse model transplanted with human leukemia cells, the leukemia burden of the mice in the ARV-825 experimental group was significantly lower than that in the control group, and their survival time was also longer than that in the control group.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 28 nM(Kd)

Target	Value
BRD4 BD2 (Cell-free assay)
BRD4 BD1 (Cell-free assay)	90 nM(Kd)

References

[1] Lu J, et al. Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4. Chem Biol. 2015 Jun 18;22(6):755-63. DOI:10.1016/j.chembiol.2015.05.009

ARV-825 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ARV-825 manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: ARV-825 1818885-28-7
Price: US $0.00/mg
Min. Order: 1mg
Purity: 98%min
Supply Ability: 500mg
Release date: 2021-08-26

Career Henan Chemical Co

Product: ARV-825 1818885-28-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-13

1818885-28-7, ARV-825Related Search:

ARV110 ARCC-4 ARV-771 ARV-471

ARV-825

AVR-825

CS-2252

ARV-825;ARV 825;ARV825

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]-2,3,9-trimethyl-, (6S)-

Epigenetic Reader Domain,inhibit,PROTACs,ARV 825,Inhibitor,ARV825,ARV-825

2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide

ARV-825, 10 mM in DMSO

2-[(S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-[4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-4-isoindolinyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]acetamide

ARV-825 ，S8297

1818885-28-7

C46H47ClN8O9S