ChemicalBook > CAS DataBase List > ARV-825

ARV-825

Product Name
ARV-825
CAS No.
1818885-28-7
Chemical Name
ARV-825
Synonyms
AVR-825;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]-2,3,9-trimethyl-, (6S)-;CS-2252;ARV-825;ARV-825;ARV 825;ARV825;Epigenetic Reader Domain,inhibit,PROTACs,ARV 825,Inhibitor,ARV825,ARV-825;2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide
CBNumber
CB13041384
Molecular Formula
C46H47ClN8O9S
Formula Weight
923.43
MOL File
1818885-28-7.mol
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ARV-825 Property

Density 
1.47±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
DMSO:5.0(Max Conc. mg/mL);5.41(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);5.41(Max Conc. mM)
Water:0.0(Max Conc. mg/mL);0.0(Max Conc. mM)
form 
A crystalline solid
pka
10.74±0.40(Predicted)
color 
Light yellow to yellow
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3423
Product name
ARV-825
Purity
≥98% (HPLC)
Packaging
5MG
Price
$103
Updated
2023/06/20
Sigma-Aldrich
Product number
SML3423
Product name
ARV-825
Purity
≥98% (HPLC)
Packaging
25MG
Price
$415
Updated
2023/06/20
Cayman Chemical
Product number
21109
Product name
ARV-825
Purity
≥98%
Packaging
500μg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
21109
Product name
ARV-825
Purity
≥98%
Packaging
1mg
Price
$92
Updated
2024/03/01
Cayman Chemical
Product number
21109
Product name
ARV-825
Purity
≥98%
Packaging
5mg
Price
$403
Updated
2024/03/01
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ARV-825 Chemical Properties,Usage,Production

Description

ARV-825 is a PROTAC molecule composed of a BRD4 binding moiety joined to an E3 ligase cereblon binding moiety. ARV-825 recruits BRD4 to E3 ubiquitin ligase cereblon, resulting in the degradation of BRD4.

Biological Activity

ARV-825 is a BRD4 inhibitor that recruits BRD4 to the E3 ubiquitin ligase cereblon, causing rapid, efficient and sustained degradation of BRD4 protein and sustained downregulation of MYC levels.

in vivo

In the mouse model transplanted with human leukemia cells, the leukemia burden of the mice in the ARV-825 experimental group was significantly lower than that in the control group, and their survival time was also longer than that in the control group.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 28 nM(Kd)
TargetValue
BRD4 BD2
(Cell-free assay)
BRD4 BD1
(Cell-free assay)		 90 nM(Kd)

ARV-825 Preparation Products And Raw materials

Raw materials

Preparation Products

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ARV-825 Suppliers

China 60 India 1 United States 8 Global 69
Haoyuan Chemexpress Co., Ltd.
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View Lastest Price from ARV-825 manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
ARV-825 1818885-28-7
Price
US $0.00/mg
Min. Order
1mg
Purity
98%min
Supply Ability
500mg
Release date
2021-08-26
Career Henan Chemical Co
Product
ARV-825 1818885-28-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-13

1818885-28-7, ARV-825Related Search:

3-Pyridazinecarboxamide, N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]- ARCC-4 ARV-771 ARV-471

  • ARV-825
  • AVR-825
  • CS-2252
  • ARV-825;ARV 825;ARV825
  • 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]-2,3,9-trimethyl-, (6S)-
  • Epigenetic Reader Domain,inhibit,PROTACs,ARV 825,Inhibitor,ARV825,ARV-825
  • 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide
  • 1818885-28-7
  • C46H47ClN8O9S