ARV-825

Product Name: ARV-825
CAS No.: 1818885-28-7
Chemical Name: ARV-825
Synonyms: AVR-825;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]-2,3,9-trimethyl-, (6S)-;CS-2252;ARV-825;ARV-825;ARV 825;ARV825;Epigenetic Reader Domain,inhibit,PROTACs,ARV 825,Inhibitor,ARV825,ARV-825;2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide
CBNumber: CB13041384
Molecular Formula: C46H47ClN8O9S
Formula Weight: 923.43
MOL File: 1818885-28-7.mol

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ARV-825 Property

Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO:5.0(Max Conc. mg/mL);5.41(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);5.41(Max Conc. mM)
Water:0.0(Max Conc. mg/mL);0.0(Max Conc. mM)
form: A crystalline solid
pka: 10.74±0.40(Predicted)
color: Light yellow to yellow

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3423
Product name: ARV-825
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $103
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML3423
Product name: ARV-825
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $415
Updated: 2023/06/20

Cayman Chemical

Product number: 21109
Product name: ARV-825
Purity: ≥98%
Packaging: 500μg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 21109
Product name: ARV-825
Purity: ≥98%
Packaging: 1mg
Price: $92
Updated: 2024/03/01

Cayman Chemical

Product number: 21109
Product name: ARV-825
Purity: ≥98%
Packaging: 5mg
Price: $403
Updated: 2024/03/01

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ARV-825 Chemical Properties,Usage,Production

Description

ARV-825 is a PROTAC molecule composed of a BRD4 binding moiety joined to an E3 ligase cereblon binding moiety. ARV-825 recruits BRD4 to E3 ubiquitin ligase cereblon, resulting in the degradation of BRD4.

Biological Activity

ARV-825 is a BRD4 inhibitor that recruits BRD4 to the E3 ubiquitin ligase cereblon, causing rapid, efficient and sustained degradation of BRD4 protein and sustained downregulation of MYC levels.

in vivo

In the mouse model transplanted with human leukemia cells, the leukemia burden of the mice in the ARV-825 experimental group was significantly lower than that in the control group, and their survival time was also longer than that in the control group.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 28 nM(Kd)

Target	Value
BRD4 BD2 (Cell-free assay)
BRD4 BD1 (Cell-free assay)	90 nM(Kd)

ARV-825 Preparation Products And Raw materials

Raw materials

Preparation Products

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ARV-825 Suppliers

China 60 India 1 United States 8 Global 69

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
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EnliPharma Technology Co., Ltd

Tel: 0551-66399836 18955197623
Email: sales@enlipharma.com
Country: China
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4566
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Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 1005
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
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ShangHai Biochempartner Co.,Ltd

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Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
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Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
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ProdList: 2991
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Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29785
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Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
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View Lastest Price from ARV-825 manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: ARV-825 1818885-28-7
Price: US $0.00/mg
Min. Order: 1mg
Purity: 98%min
Supply Ability: 500mg
Release date: 2021-08-26

Career Henan Chemical Co

Product: ARV-825 1818885-28-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-13

1818885-28-7, ARV-825Related Search:

3-Pyridazinecarboxamide, N-[trans-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]- ARCC-4 ARV-771 ARV-471

ARV-825

AVR-825

CS-2252

ARV-825;ARV 825;ARV825

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]-2,3,9-trimethyl-, (6S)-

Epigenetic Reader Domain,inhibit,PROTACs,ARV 825,Inhibitor,ARV825,ARV-825

2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide

1818885-28-7

C46H47ClN8O9S