ChemicalBook > CAS DataBase List > ARV-825
ARV-825
- Product Name
- ARV-825
- CAS No.
- 1818885-28-7
- Chemical Name
- ARV-825
- Synonyms
- AVR-825;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]-2,3,9-trimethyl-, (6S)-;CS-2252;ARV-825;ARV-825;ARV 825;ARV825;Epigenetic Reader Domain,inhibit,PROTACs,ARV 825,Inhibitor,ARV825,ARV-825;2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide
- CBNumber
- CB13041384
- Molecular Formula
- C46H47ClN8O9S
- Formula Weight
- 923.43
- MOL File
- 1818885-28-7.mol
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ARV-825 Property
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO:5.0(Max Conc. mg/mL);5.41(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);5.41(Max Conc. mM)
Water:0.0(Max Conc. mg/mL);0.0(Max Conc. mM) - form
- A crystalline solid
- pka
- 10.74±0.40(Predicted)
- color
- Light yellow to yellow
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Safety
- HS Code
- 2933998090
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML3423
- Product name
- ARV-825
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $103
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- SML3423
- Product name
- ARV-825
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $415
- Updated
- 2023/06/20
Cayman Chemical
- Product number
- 21109
- Product name
- ARV-825
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $49
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21109
- Product name
- ARV-825
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $92
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21109
- Product name
- ARV-825
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $403
- Updated
- 2024/03/01
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ARV-825 Chemical Properties,Usage,Production
Description
ARV-825 is a PROTAC molecule composed of a BRD4 binding moiety joined to an E3 ligase cereblon binding moiety. ARV-825 recruits BRD4 to E3 ubiquitin ligase cereblon, resulting in the degradation of BRD4.
Biological Activity
ARV-825 is a BRD4 inhibitor that recruits BRD4 to the E3 ubiquitin ligase cereblon, causing rapid, efficient and sustained degradation of BRD4 protein and sustained downregulation of MYC levels.
in vivo
In the mouse model transplanted with human leukemia cells, the leukemia burden of the mice in the ARV-825 experimental group was significantly lower than that in the control group, and their survival time was also longer than that in the control group.
target
| Target | Value |
| BRD4 BD2 (Cell-free assay) | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 28 nM(Kd)|
| BRD4 BD1 (Cell-free assay) | 90 nM(Kd) |
ARV-825 Preparation Products And Raw materials
Raw materials
Preparation Products
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ARV-825 Suppliers
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View Lastest Price from ARV-825 manufacturers
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- ARV-825 1818885-28-7
- Price
- US $0.00/mg
- Min. Order
- 1mg
- Purity
- 98%min
- Supply Ability
- 500mg
- Release date
- 2021-08-26
Career Henan Chemical Co
- Product
- ARV-825 1818885-28-7
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-13
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