ChemicalBook > CAS DataBase List > EPZ020411
EPZ020411
- Product Name
- EPZ020411
- CAS No.
- 1700663-41-7
- Chemical Name
- EPZ020411
- Synonyms
- CS-2262;EPZ020411;EPZ020411 2HCl;EPZ020411 HCl;EPZ 020411;EPZ-020411;N1,N2-dimethyl-N1-((3-(4-((1r,3r)-3-(2-(tetrahydro-2H-pyran-4-yl)ethoxy)cyclobutoxy)phenyl)-1H-pyrazol-4-yl)methyl)ethane-1,2-diamine;1,2-Ethanediamine, N1,N2-dimethyl-N1-[[3-[4-[[trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl]oxy]phenyl]-1H-pyrazol-4-yl]methyl]-
- CBNumber
- CB13048651
- Molecular Formula
- C25H38N4O3
- Formula Weight
- 442.59
- MOL File
- 1700663-41-7.mol
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EPZ020411 Property
- Boiling point:
- 619.2±55.0 °C(Predicted)
- Density
- 1.16±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- crystalline solid
- pka
- 14.53±0.50(Predicted)
- color
- Off-white to yellow
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 19160
- Product name
- EPZ020411
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $47
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19160
- Product name
- EPZ020411
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $206
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19160
- Product name
- EPZ020411
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $360
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19160
- Product name
- EPZ020411
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $788
- Updated
- 2024/03/01
ApexBio Technology
- Product number
- B6088
- Product name
- EPZ020411
- Packaging
- 50mg
- Price
- $2048
- Updated
- 2021/12/16
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EPZ020411 Chemical Properties,Usage,Production
Biological Activity
epz020411 is an inhibitor of prmt6.prmt6, a member of the protein arginine methyltransferasefamily, comprises 45 enzymes. the post-translational modifications of prmt6 are important regulators of rna processing, transcriptional regulation, and signal transduction.
in vitro
in biochemical assays, epz020411 was found to be over 100-fold selective for prmt6/8/1 compared to other histone methyltransferases, such as prmt3, prmt4, prmt5 and prmt7. in addition, epz020411 treatment led to a dose-dependent decrease in h3r2 methylation, while treatment with its prmt6-inactive analog did not generate an ic50 at concentrations up to 20 μm [1].
in vivo
animal study found that male sd rats i.v. administered a single dose of epz020411 at 1 mg/kg showed a moderate clearance of 19.7 ml/min/kg, with a volume of distribution at steady state of 11.1 l/kg, and a mean terminal half-life of 8.54 h. following 5 mg/kg s.c. dosing, a good bioavailability of 65.6 was observed, resulting in epz020411 unbound concentration remaining over the prmt6 ic50 for more than 12 h [1].
IC 50
10 nm
References
[1] mitchell lh, et al. aryl pyrazoles as potent inhibitors of arginine methyltransferases: identification of the first prmt6 toolcompound. acs med chem lett. 2015 apr 6;6(6):655-659.
EPZ020411 Preparation Products And Raw materials
Raw materials
Preparation Products
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