2,2-DIMETHYL-4-OXO-3,8,11,14-TETRAOXA-5-AZAHEXADECAN-16-OIC ACID

Product Name: 2,2-DIMETHYL-4-OXO-3,8,11,14-TETRAOXA-5-AZAHEXADECAN-16-OIC ACID
CAS No.: 462100-06-7
Chemical Name: 2,2-DIMETHYL-4-OXO-3,8,11,14-TETRAOXA-5-AZAHEXADECAN-16-OIC ACID
Synonyms: Boc-PEG3- CH2COOH;NHBoc-PEG3-CH2COOH;BocNH-PEG3-CH2COOH;Boc-N-amido-PEG3-CH2CO2H;t-boc-N-amido-PEG3-acetic acid;t-Boc-N-amido-PEG3-CH2CO2H >=95%;Boc-PEG3-CH2COOH [452100-06-7];Boc-11-amino-3,6,9-trioxaundecanoic acid;2-[2-[2-[2-(Boc-amino)ethoxy]ethoxy]ethoxy]acetic Acid;2,2-Dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azahexadecan-16-
CBNumber: CB13059752
Molecular Formula: C13H25NO7
Formula Weight: 307.34
MOL File: 462100-06-7.mol

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2,2-DIMETHYL-4-OXO-3,8,11,14-TETRAOXA-5-AZAHEXADECAN-16-OIC ACID Property

Boiling point:: 460.1±35.0 °C(Predicted)
Density: 1.141±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMF: 5 mg/ml,DMSO: 1 mg/ml,Ethanol: 30 mg/ml
form: A neat oil
pka: 3.39±0.10(Predicted)
color: Colorless to light yellow
InChI: InChI=1S/C13H25NO7/c1-13(2,3)21-12(17)14-4-5-18-6-7-19-8-9-20-10-11(15)16/h4-10H2,1-3H3,(H,14,17)(H,15,16)
InChIKey: IFSMYFLQPDFUOI-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NCCOCCOCCOCC(O)=O
CAS DataBase Reference: 462100-06-7

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Safety

HS Code: 2924190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 901575
Product name: t-Boc-N-amido-PEG3-CH2CO2H
Purity: ≥95%
Packaging: 50MG
Price: $65.87
Updated: 2025/07/31

Cayman Chemical

Product number: 30536
Product name: Boc-NH-PEG3-CH2COOH
Packaging: 50mg
Price: $65
Updated: 2024/03/01

Cayman Chemical

Product number: 30536
Product name: Boc-NH-PEG3-CH2COOH
Packaging: 100mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 30536
Product name: Boc-NH-PEG3-CH2COOH
Packaging: 25mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 30536
Product name: Boc-NH-PEG3-CH2COOH
Packaging: 250mg
Price: $283
Updated: 2024/03/01

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2,2-DIMETHYL-4-OXO-3,8,11,14-TETRAOXA-5-AZAHEXADECAN-16-OIC ACID Chemical Properties,Usage,Production

Description

t-Boc-N-amido-PEG3-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

This is a crosslinker with a t-Boc protected amine on one end and a carboxyl group on the other end. The compound contains three PEG units to help improve solubility.

reaction suitability

reagent type: linker

Synthesis

79-08-3

139115-92-7

462100-06-7

To a 1000 mL three-neck flask was added 34.8 g of tert-butyl (2-(2-(2-hydroxyethoxy)ethoxy)ethyl)carbamate (1.0 eq.), 150 mL of toluene, and 150 mL of THF, 58.2 g of bromoacetic acid (3 eq.), and stirred to mix. The reaction mixture was heated to 45?50°C followed by the slow addition of 33.5 g of sodium hydroxide (6 eq.). The reaction was continued at room temperature overnight. The progress of the reaction was monitored by TLC. After completion of the reaction, the solvent was removed by evaporation. The residue was separated by extraction with water and ethyl acetate. The aqueous phase was adjusted to pH 3 with hydrochloric acid and subsequently extracted with dichloromethane. The dichloromethane layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated to give 18 g of 5,8,11-trioxa-2-azatridecanedioic acid 1-tert-butyl ester (BP103a05) as an oil.

IC 50

PEGs; Alkyl/ether

References

[1] Inorganica Chimica Acta, 2011, vol. 365, # 1, p. 38 - 48
[2] Patent: EP3321279, 2018, A1. Location in patent: Paragraph 0066

2,2-DIMETHYL-4-OXO-3,8,11,14-TETRAOXA-5-AZAHEXADECAN-16-OIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2-DIMETHYL-4-OXO-3,8,11,14-TETRAOXA-5-AZAHEXADECAN-16-OIC ACID Suppliers

China 115 India 1 United Kingdom 1 United States 7 Global 124

Carbosynth

Tel: --
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Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
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View Lastest Price from 2,2-DIMETHYL-4-OXO-3,8,11,14-TETRAOXA-5-AZAHEXADECAN-16-OIC ACID manufacturers

LAURENT

Product: BocNH-PEG3-CH2COOH 462100-06-7
Price: US $23.28/g
Min. Order: 10g
Purity: 98%
Supply Ability: 300kg
Release date: 2025-11-20

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: 2,2-dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azahexadecan-16-oic acid 462100-06-7
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
Release date: 2025-09-12

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Boc-NH-PEG3-CH2COOH 462100-06-7
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-08-06

462100-06-7, 2,2-DIMETHYL-4-OXO-3,8,11,14-TETRAOXA-5-AZAHEXADECAN-16-OIC ACIDRelated Search:

N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL NITRIC OXIDE Boc-NH-PEG7-CH2CH2COOH 22-Amino-5,8,11,14,17,20-hexaoxa-2-azadocosanoic acid 1,1-dimethylethyl ester NITROUS OXIDE Fmoc-N-amido-PEG1-acid Acetic acid, [2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]- (9CI) FMOC-12-AMINO-4,7,10-TRIOXADODECANOIC ACID FMOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID 5,8,11,14-Tetraoxa-2-azahexadecanedioic acid FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID Fmoc-NH-PEG3-CH2COOH 5-(9-FLUORENYLMETHYLOXYCARBONYL-AMINO)-3-OXAPENTANOIC ACID Fmoc-9-Amino-4,7-Dioxanonanoic acid 5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioic acid,1-(9-fluren-9-ylmethyl)ester FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID BOC-8-AMINO-3,6-DIOXAOCTANOIC ACID DCHA FMoc-NH-PEG9-CH2CH2COOH

5,8,11-Trioxa-2-azatridecanedioic acid 1-(1,1-dimethylethyl) ester

Boc-N-amido-PEG3-CH2CO2H

Boc-PEG3- CH2COOH

Boc-11-amino-3,6,9-trioxaundecanoic acid

t-boc-N-amido-PEG3-acetic acid

BocNH-PEG3-CH2COOH

2-[2-[2-[2-(Boc-amino)ethoxy]ethoxy]ethoxy]acetic Acid

2,2-DIMETHYL-4-OXO-3,8,11,14-TETRAOXA-5-AZAHEXADECAN-16-OIC ACID

52,2-Dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azahexadecan-16-oic acid

t-Boc-N-amido-PEG3-CH2CO2H >=95%

NHBoc-PEG3-CH2COOH

BocNH-PEG3-CH2COOH/5,8,11-Trioxa-2-azatridecanedioic acid, 1-(1,1-dimethylethyl) ester

2,2-Dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azahexadecan-16-

t-Boc-N-amido-PEG3-CH2CO2H

Boc-PEG3-CH2COOH [452100-06-7]

462100-06-7

C13H25NO7

peg