N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL
Uses- Product Name
- N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL
- CAS No.
- 106984-09-2
- Chemical Name
- N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL
- Synonyms
- BocNH-PEG4-OH;2-[2-(2-(2-Boc-aminoethoxy)ethoxy)ethoxy]ethanol;(2-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethoxy}-ethyl)-carbamic Acid tert-Butyl Ester;Boc-NH-PEG4;NHBoc-PEG4-OH;PROTAC Linker 12;N-Boc-PEG4-alcohol;BocNH-PEG4-alcohol;t-boc-N-amido-dPEG??-OH;t-Boc-Amido-PEG4-Alcohol
- CBNumber
- CB8285205
- Molecular Formula
- C13H27NO6
- Formula Weight
- 293.36
- MOL File
- 106984-09-2.mol
N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL Property
- Boiling point:
- 414.0±35.0 °C(Predicted)
- Density
- 1.078±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 12.23±0.46(Predicted)
- form
- Oil
- color
- Clear Light Yellow
- InChI
- InChI=1S/C13H27NO6/c1-13(2,3)20-12(16)14-4-6-17-8-10-19-11-9-18-7-5-15/h15H,4-11H2,1-3H3,(H,14,16)
- InChIKey
- XKKDQIAPTPFIGW-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NCCOCCOCCOCCO
Safety
- HS Code
- 2924190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B621250
- Product name
- 1-Boc-amino-3,6,9-trioxaundecanyl-11-ol
- Packaging
- 500mg
- Price
- $420
- Updated
- 2021/12/16
- Product number
- FB18919
- Product name
- 1-Boc-amino-3,6,9-trioxaundecanyl-11-ol
- Packaging
- 50mg
- Price
- $72.5
- Updated
- 2021/12/16
- Product number
- 8350AC
- Product name
- tert-Butyl2-(2-(2-(2-hydroxyethoxy)-ethoxy)ethoxy)ethylcarbamate
- Packaging
- 100mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- FB18919
- Product name
- 1-Boc-amino-3,6,9-trioxaundecanyl-11-ol
- Packaging
- 100mg
- Price
- $116
- Updated
- 2021/12/16
- Product number
- 8350AC
- Product name
- tert-Butyl2-(2-(2-(2-hydroxyethoxy)-ethoxy)ethoxy)ethylcarbamate
- Packaging
- 1g
- Price
- $170
- Updated
- 2021/12/16
N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL Chemical Properties,Usage,Production
Uses
1-Boc-amino-3,6,9-trioxaundecanyl-11-ol is a compound useful in organic synthesis.
Description
N-Boc-PEG4-alcohol is a PEG linker containing a hydroxyl group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Chemical Properties
Yellow Oil
Uses
Boc-NH-PEG4 (PROTAC Linker 12) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Synthesis
24424-99-5
86770-74-3
106984-09-2
Example 5: Synthesis of tert-butyl (2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl) carbamate Step 1: Synthesis of S9 In a round bottom flask, 1-amino-3,6,9-trioxa-11-undecanol (2.9 g, 15 mmol) was dissolved in 10 mL of ethanol. Another di-tert-butyl dicarbonate (3.6 g, 16.5 mmol) was dissolved in 10 mL of ethanol and added to the above solution slowly and dropwise over 10 minutes. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was removed by rotary evaporator and the residue was purified by column chromatography using dichloromethane/methanol system to give S9 as a colorless oil (3.69 g, 80% yield). 1H NMR (400 MHz, CDCl3) δ (ppm): 5.49 (s, 1H), 3.46-3.25 (m, 14H), 3.02 (s, 2H), 1.18 (s, 9H); ESI-MS calculated value C13H27NNaO4 [M + Na]+ = 316.17, measured value: 316.18.
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL manufacturers
- Product
- BocNH-PEG4-OH 106984-09-2
- Price
- US $19.29/g
- Min. Order
- 10g
- Purity
- 98%
- Supply Ability
- 300kg
- Release date
- 2025-11-18
- Product
- N-Boc-PEG4-alcohol 106984-09-2
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-08-06
- Product
- NHBoc-PEG4-OH 106984-09-2
- Price
- US $0.00/g
- Min. Order
- 25g
- Purity
- >98.00%
- Supply Ability
- 25g
- Release date
- 2024-03-25