ChemicalBook > CAS DataBase List > N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL

N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL

Uses

Product Name: N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL
CAS No.: 106984-09-2
Chemical Name: N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL
Synonyms: BocNH-PEG4-OH;2-[2-(2-(2-Boc-aminoethoxy)ethoxy)ethoxy]ethanol;(2-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethoxy}-ethyl)-carbamic Acid tert-Butyl Ester;Boc-NH-PEG4;NHBoc-PEG4-OH;PROTAC Linker 12;N-Boc-PEG4-alcohol;BocNH-PEG4-alcohol;t-boc-N-amido-dPEG??-OH;t-Boc-Amido-PEG4-Alcohol
CBNumber: CB8285205
Molecular Formula: C13H27NO6
Formula Weight: 293.36
MOL File: 106984-09-2.mol

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N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL Property

Boiling point:: 414.0±35.0 °C(Predicted)
Density: 1.078±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 12.23±0.46(Predicted)
form: Oil
color: Clear Light Yellow
InChI: InChI=1S/C13H27NO6/c1-13(2,3)20-12(16)14-4-6-17-8-10-19-11-9-18-7-5-15/h15H,4-11H2,1-3H3,(H,14,16)
InChIKey: XKKDQIAPTPFIGW-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NCCOCCOCCOCCO

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Safety

HS Code: 2924190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B621250
Product name: 1-Boc-amino-3,6,9-trioxaundecanyl-11-ol
Packaging: 500mg
Price: $420
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 7582
Product name: 1-Boc-amino-3,6,9-trioxaundecanyl-11-ol
Packaging: 100mg
Price: $490
Updated: 2021/12/16

Matrix Scientific

Product number: 089570
Product name: tert-Butyl 2-(2-(2-(2-hydroxyethoxy)-ethoxy)ethoxy)ethyl carbamate
Packaging: 1g
Price: $553
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB18919
Product name: 1-Boc-amino-3,6,9-trioxaundecanyl-11-ol
Packaging: 1g
Price: $600
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1661
Product name: N-Boc-PEG4-alcohol
Packaging: 500mg
Price: $623
Updated: 2021/12/16

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N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL Chemical Properties,Usage,Production

Uses

1-Boc-amino-3,6,9-trioxaundecanyl-11-ol is a compound useful in organic synthesis.

Description

N-Boc-PEG4-alcohol is a PEG linker containing a hydroxyl group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Chemical Properties

Yellow Oil

Uses

Boc-NH-PEG4 (PROTAC Linker 12) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

Synthesis

24424-99-5

86770-74-3

106984-09-2

Example 5: Synthesis of tert-butyl (2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl) carbamate Step 1: Synthesis of S9 In a round bottom flask, 1-amino-3,6,9-trioxa-11-undecanol (2.9 g, 15 mmol) was dissolved in 10 mL of ethanol. Another di-tert-butyl dicarbonate (3.6 g, 16.5 mmol) was dissolved in 10 mL of ethanol and added to the above solution slowly and dropwise over 10 minutes. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was removed by rotary evaporator and the residue was purified by column chromatography using dichloromethane/methanol system to give S9 as a colorless oil (3.69 g, 80% yield). 1H NMR (400 MHz, CDCl3) δ (ppm): 5.49 (s, 1H), 3.46-3.25 (m, 14H), 3.02 (s, 2H), 1.18 (s, 9H); ESI-MS calculated value C13H27NNaO4 [M + Na]+ = 316.17, measured value: 316.18.

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL Suppliers

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View Lastest Price from N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL manufacturers

LAURENT

Product: BocNH-PEG4-OH 106984-09-2
Price: US $19.29/g
Min. Order: 10g
Purity: 98%
Supply Ability: 300kg
Release date: 2025-11-18

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: N-Boc-PEG4-alcohol 106984-09-2
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-08-06

Xian confluore Biological Technology Co., Ltd.

Product: NHBoc-PEG4-OH 106984-09-2
Price: US $0.00/g
Min. Order: 25g
Purity: >98.00%
Supply Ability: 25g
Release date: 2024-03-25

106984-09-2, N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOLRelated Search:

2,2-DIMETHYL-4-OXO-3,8,11,14-TETRAOXA-5-AZAHEXADECAN-16-OIC ACID Fmoc-8-amino-3,6-dioxaoctanoic acid BOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)OCTAETHYLENE GLYCOL BOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID ALPHA-TERT-BUTYLOXYCARBONYL-AMINO-OMEGA-CARBOXYLIC ACID OCTA(ETHYLENE GLYCOL) O-(2-(BOC-AMINO)-ETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG6 N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL ALPHA-TERT-BUTYLOXYCARBONYL-AMINO-OMEGA-CARBOXYLIC ACID DODECA(ETHYLENE GLYCOL) 3-(11-BOC-AMINO-3,6,9-TRIOXAUNDECANOXY)BENZOIC ACID METHYL ESTER O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)DECAETHYLENE GLYCOL O-(2-AMINOETHYL)-O'-(2-(BOC-AMINO)ETHYL) BOC-PEG-ACID BOC-11-AMINO-3,6,9-TRIOXAUNDECANOIC ACID DCHA

N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL

N-Boc-aminoethoxy-ethoxy-ethoxy-ethanol

(2-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethoxy}-ethyl)-carbamic Acid tert-Butyl Ester

1-Boc-amino-3,6,9-trioxaundecanyl-11-ol

2-[2-(2-(2-Boc-aminoethoxy)ethoxy)ethoxy]ethanol

t-boc-N-amido-PEG4-alcohol

BocNH-PEG4-OH

tert-Butyl 2-(2-(2-(2-hydroxyethoxy)-ethoxy)ethoxy)ethyl carbamate

N-Boc-PEG4-alcohol

NHBoc-PEG4-OH

5,8,11-Trioxa-2-azatridecanoicacid, 13-hydroxy-, 1,1-dimethylethyl ester

N-Boc-PEG4-alcohol,BocNH-PEG4-OH

Boc-NH-PEG4

PROTAC Linker 12

t-boc-N-amido-dPEG??-OH

BocNH-PEG4-alcohol

tert-butyl N-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]carbamate

tert-Butyl (2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)carbamat

t-Boc-Amido-PEG4-Alcohol

t-boc-N-amido-dPEG??-OH (QBD-10250)

106984-09-2

106974-09-2

Aliphatics, Amines

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