DBCO-S-S-PEG3-Biotin

Product Name: DBCO-S-S-PEG3-Biotin
CAS No.: 1430408-09-5
Chemical Name: DBCO-S-S-PEG3-Biotin
Synonyms: CAS_1430408-09-5;Biotin-PEG3-SS-DBCO;DBCO-S-S-PEG3-Biotin;Disulfide Biotin DBCO (CCT-A112);Dibenzocyclooctyne-S-S-PEG3-Biotin;inhibit,PROTAC Linkers,DBCO-S-S-PEG-3-biotin,Inhibitor,DBCOSSPEG3biotin,DBCO S S PEG3 biotin;Dibenz[b,f]azocine-5(6H)-butanamide, 11,12-didehydro-N-[25-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-7,21-dioxo-11,14,17-trioxa-3,4-dithia-8,20-diazapentacos-1-yl]-γ-oxo-;N-[24-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-13,21,24-trioxo-3,6,9-trioxa-16,17-dithia-12,20-diazatetracos-1-yl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
CBNumber: CB13062468
Molecular Formula: C42H56N6O8S3
Formula Weight: 869.12
MOL File: 1430408-09-5.mol

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DBCO-S-S-PEG3-Biotin Property

Boiling point:: 1194.2±65.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
solubility: DMSO : 100 mg/mL (115.06 mM; Need ultrasonic)
form: Oil
pka: 13.90±0.40(Predicted)
color: Light yellow to brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical

Product number: D5552
Product name: Dibenzocyclooctyne-S-S-PEG3-Biotin
Packaging: 25MG
Price: $509
Updated: 2025/07/31

BroadPharm

Product number: BP-22453
Product name: DBCO-S-S-PEG3-biotin
Purity: 95%
Packaging: 100mg
Price: $1395
Updated: 2021/12/16

Chem-Impex

Product number: 35070
Product name: DisulfidebiotinDBCO,≥90%(HPLC)
Purity: ≥90%(HPLC)
Packaging: 100MG
Price: $1741.38
Updated: 2021/12/16

BroadPharm

Product number: BP-22453
Product name: DBCO-S-S-PEG3-biotin
Purity: 95%
Packaging: 5mg
Price: $139
Updated: 2021/12/16

Chem-Impex

Product number: 35070
Product name: DisulfidebiotinDBCO,≥90%(HPLC)
Purity: ≥90%(HPLC)
Packaging: 5MG
Price: $174.72
Updated: 2021/12/16

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DBCO-S-S-PEG3-Biotin Chemical Properties,Usage,Production

Description

DBCO-S-S-PEG3-biotin is a cleavable reagent for introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry. PEG spacer arm provides better solubility to the labeled molecules in aqueous media. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP.

Uses

DBCO-S-S-PEG3-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-S-S-PEG3-biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

DBCO-S-S-PEG3-Biotin Preparation Products And Raw materials

Raw materials

Preparation Products

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DBCO-S-S-PEG3-Biotin Suppliers

Americas 1 CHINA 39 Europe 1 India 1 Japan 1 United States 2 Global 45

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
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Advantage: 80

TCI Europe

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Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
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TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
Advantage: 75

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: 021-58088081 Q2635253576
Fax: QQ3382968513
Email: hailey@shsendpharm.com
Country: China
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Borenpharm Co., Ltd

Tel: 027-65563561
Fax: 86-27-59218822
Email: sales@borenpharm.com
Country: China
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Jinan elephant international trading co., LTD

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Country: China
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Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
ProdList: 4952
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
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Wuhan Borenpharm Co., Ltd

Tel: 027-65563561 18717150066
Fax: 027-59218822
Email: 3207347307@qq.com
Country: CHINA
ProdList: 1238
Advantage: 58

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View Lastest Price from DBCO-S-S-PEG3-Biotin manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Biotin-PEG3-SS-DBCO 1430408-09-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: >98.00%
Supply Ability: 50
Release date: 2024-03-20

1430408-09-5, DBCO-S-S-PEG3-BiotinRelated Search:

Biotin-PEG3-Mal DBCO-S-S-acid Biotin-PEG3-propionic acid Biotin-PEG3-NHS ester DBCO-PEG3-NH2 Sulfo-NHS-SS-Biotin N-BIOTINYL-3,6-DIOXAOCTANE-1,8-DIAMINE Sulfo-NHS-Biotin BIOTIN-NHS Biotin-PEG3-oxyamine BIOTINAMIDOCAPROYL HYDRAZIDE Biotin-PEG3-propionic hydrazide BIOTIN-X-NHS, WATER-SOLUBLE, CLEAVABLE BIOTIN DISULFIDE N-HYDROXY-SUCCINIMIDE ESTER BIOTIN HYDRAZIDE N-BIOTINYL-3,6,9-TRIOXAUNDECANE-1,11-DIAMINE Biotin-PEG3-SH Biotin-peg3-alcohol

DBCO-S-S-PEG3-Biotin

CAS_1430408-09-5

Biotin-PEG3-SS-DBCO

Dibenzocyclooctyne-S-S-PEG3-Biotin

N-[24-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-13,21,24-trioxo-3,6,9-trioxa-16,17-dithia-12,20-diazatetracos-1-yl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide

inhibit,PROTAC Linkers,DBCO-S-S-PEG-3-biotin,Inhibitor,DBCOSSPEG3biotin,DBCO S S PEG3 biotin

Dibenz[b,f]azocine-5(6H)-butanamide, 11,12-didehydro-N-[25-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-7,21-dioxo-11,14,17-trioxa-3,4-dithia-8,20-diazapentacos-1-yl]-γ-oxo-

Disulfide Biotin DBCO (CCT-A112)

1430408-09-5

C42H56N6O8S3