Teicoplanin

ChemicalBook > CAS DataBase List > Teicoplanin

Mode of action

Product Name: Teicoplanin
CAS No.: 61036-62-2
Chemical Name: Teicoplanin
Synonyms: TEIC;8327a;Tagocid;18-[(3AS;Ticoplanin;Teicalnine;Telcoplanin;TEICOPLANIN;teichomycin;Teocoplanin
CBNumber: CB1308141
Molecular Formula: C78H77Cl2N8O32R
Formula Weight: 1709.39
MOL File: 61036-62-2.mol

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Teicoplanin Property

Melting point:: 310 °C (decomp)
RTECS: WY1559000
storage temp.: 2-8°C
solubility: H2O: soluble10mg/mL
form: powder
color: white to faint yellow
Water Solubility: Sparingly soluble in water
CAS DataBase Reference: 61036-62-2

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Safety

WGK Germany: 3
HS Code: 2941900000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T0578
Product name: Teicoplanin
Purity: ≥80% (teicoplanins A2, HPLC)
Packaging: 1g
Price: $703
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR1811
Product name: Teicoplanin
Packaging: 100mg
Price: $179
Updated: 2024/03/01

Alfa Aesar

Product number: J66785
Product name: Teicoplanin
Purity: cont. 80+% A2
Packaging: 100mg
Price: $123
Updated: 2023/06/20

Alfa Aesar

Product number: J66785
Product name: Teicoplanin
Purity: cont. 80+% A2
Packaging: 500mg
Price: $355
Updated: 2023/06/20

Cayman Chemical

Product number: 15511
Product name: Teicoplanin Complex
Purity: ≥95%
Packaging: 25mg
Price: $73
Updated: 2024/03/01

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Teicoplanin Chemical Properties,Usage,Production

Mode of action

Once the muramylpentapeptide is formed in the cell cytoplasm, an N-acetylglucosamine unit is added, together with any amino acids needed for the interpeptide bridge of Grampositive organisms. It is then passed to a lipid carrier molecule, which transfers the whole unit across the cell membrane to be added to the growing end of the peptidoglycan macromolecule. Addition of the new building block (transglycosylation) is prevented by teicoplanin which bind to the acyl-d-alanyl-d-alanine tail of the muramylpentapeptide. Because antibiotics are large polar molecules, they cannot penetrate the outer membrane of Gramnegative organisms, which explains their restricted spectrum of activity.

Description

Teicoplanin is a new antibiotic, the second glycopeptide to be developed in over 30 years. Compared with vancomycin, the only such agent currently available, teicoplanin is equiefficacious, and has milder side-effects and a longer half-life, allowing once-daily dosing and bolus injection. Teicoplanin is claimed to have an overall cure rate of 92% in infections involving skin, joint and bone, endocaditis and septicemia.

Chemical Properties

Yellowish, amorphous powder.

Originator

Merrell Dow (Italy)

Uses

anticonvulsant, antipsychotic

Uses

antidepressant

Uses

Teicoplanin complex is family of closely related metabolites produced by Actinoplanes teichomyceticus. Teicoplanin complex possesses potent broad spectrum antibiotic activity against Gram positive bacteria, including MRSA and E. faecalis. The metabolites share a common glycopeptide core (teicoplanin A-3) on which a family of fatty acids varying in length, degree of saturation and branching are linked as amides through one of the aminoglycoside moieties. The major component of the complex is teicoplanin A2 which itself has five major components (teicoplanin A2-1 to A2-5) and four minor components (teicoplanin RS-1 to RS-4).

brand name

Targocid

General Description

Teicoplanin (Teichomycin A2, Targocid) is a mixture offive closely related glycopeptide antibiotics produced bythe actinomycete Actinoplanes teichomyceticus. The teicoplanin factors differ only in the acyl group inthe northernmost of two glucosamines glycosidicallylinked to the cyclic peptide aglycone. Another sugar, Dmannose,is common to all of the teicoplanins. Thestructures of the teicoplanin factors were determined independentlyby a combination of chemical degradationand spectroscopic methods in three different groupsin 1984.
The teicoplanin complex is similar to vancomycin structurallyand microbiologically but has unique physical propertiesthat contribute some potentially useful advantages.While retaining excellent water solubility, teicoplanin has significantlygreater lipid solubility than vancomycin. Thus, teicoplaninis distributed rapidly into tissues and penetratesphagocytes well. The complex has a long elimination halflife,ranging from 40 to 70 hours, resulting from a combinationof slow tissue release and a high fraction of protein bindingin the plasma (～90%). Unlike vancomycin, teicoplanin isnot irritating to tissues and may be administered by intramuscularor intravenous injection. Because of its long half-life, teicoplaninmay be administered on a once-a-day dosing schedule.Orally administered teicoplanin is not absorbedsignificantly and is recovered 40% unchanged in the feces.
Teicoplanin exhibits excellent antibacterial activity againstGram-positive organisms, including staphylococci, streptococci,enterococci, Clostridium and Corynebacterium spp.,Propionibacterium acnes, and L. monocytogenes. It is not activeagainst Gram-negative organisms, including Neisseriaand Mycobacterium spp. Teicoplanin impairs bacterial cellwall synthesis by complexing with the terminal D-alanine-Dalaninedipeptide of the peptidoglycan, thus preventing crosslinkingin a manner entirely analogous to the action ofvancomycin.

Clinical Use

Antibacterial agent.

Metabolism

Teicoplanin is excreted almost entirely by glomerular filtration in the urine, as unchanged drug. Two metabolites are formed probably by hydroxylation and represents 2-3% of the administered dose. Unchanged teicoplanin is mainly excreted by the urinary route while 2.7% of the administered dose is recovered in feces (via bile excretion) within 8 days following administration.

Teicoplanin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Teicoplanin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Teicoplanin 61036-62-2
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-10-14

Hangzhou Hyper Chemicals Limited

Product: Teicoplanin 61036-62-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%, EP
Supply Ability: 5,000KG
Release date: 2024-06-06

Hebei Weibang Biotechnology Co., Ltd

Product: Teicoplanin 61036-62-2
Price: US $20.00-14.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-10-28

61036-62-2, TeicoplaninRelated Search:

Linezolid Cefoperazone sodium +sulbactam sodium(1:1/2:1) Ambroxol teicoplanin a2 Teicoplanin 2,2'-OXYBIS(ETHYLAMINE) DIHYDROCHLORIDE Ritodrine hydrochloride (R)-2-AMINO-1-(3-CHLOROPHENYL) ETHANOL HYDROCHLORIDE Benzenemethanamine, 3,4,5-trimethoxy-a-methyl-,(S)- H-PHG-NH2 HCL phenyl alpha-D-mannopyranoside (R)-4-hydroxyphenylglycine 2-(2-BIPHENYLYLOXY)ETHANOL (R)-2-AMINO-3-BENZYLOXY-1-PROPANOL HYDROCHLORIDE SALT BENZYL 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSIDE R-ALPHA-AMINO-4-METHOXYBENZENE ACETAMIDE teicoplanin A2-3 teicoplanin A2-5

Tagocid

TEIC

Teicoplanin sterile

lyophilised teicoplanin

TazobactuM SodiuM+Piperacillin SodiuM

TeichoMycin, Tecoplanin, Targocid, TeicoMid, 8327A, DL 507IT, L 12507, MDL 507, MW 1900

Teicoplanin coMplex

TEICOPLANIN [A(2-1) shown]

Ticoplanin

Teicomycin,、Targocid

Telcoplanin

Teicoplanin Complex (Tecoplanin)

TEICOPLANIN

8327a

antibiotic8327a

teichomycin

TEICOPLANIN(PATENTED)

Teocoplanin

Telicoplanin

TEICOPLANIN, JP

TeicoplaninSodium

Telcoplanin,Tecoplanin

Antibiotic MDL-507

Teicoplanin for identification CRS

Teicoplanin CRS

Teicoplanin USP/EP/BP

Teicoplanin Complex Please see T015500

TeicoplaninQ: What is Teicoplanin Q: What is the CAS Number of Teicoplanin Q: What is the storage condition of Teicoplanin Q: What are the applications of Teicoplanin

18-[(3AS

Teicoplanin (9CI, ACI)

Teicalnine

61036-62-2

616036-62-2

C78H77Cl2N8O32R

C89H99Cl2N9O29

C77H77N9O31Cl2R

Active Pharmaceutical Ingredients

API

HYAMATE

61036-62-2