ChemicalBook > CAS DataBase List > 1,1,3,3-Tetramethylurea

1,1,3,3-Tetramethylurea

Product Name
1,1,3,3-Tetramethylurea
CAS No.
632-22-4
Chemical Name
1,1,3,3-Tetramethylurea
Synonyms
TMU;TETRAMETHYLUREA;Urea, tetramethyl-;Temur;tetramethyl-ure;1,1,3,3-tetramethyl-ure;NSC 91488;((CH3)2N)2CO;TERAMETHYLUREA;Four Methylurea
CBNumber
CB1309805
Molecular Formula
C5H12N2O
Formula Weight
116.16
MOL File
632-22-4.mol
More
Less

1,1,3,3-Tetramethylurea Property

Melting point:
−1 °C(lit.)
Boiling point:
177 °C(lit.)
Density 
0.968 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.451(lit.)
Flash point:
150 °F
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Miscible with water, petroleum ether and common solvents.
form 
Liquid
pka
2.0(at 25℃)
color 
Clear colorless to pale yellow
PH
5-8 (25℃, 1M in H2O)
Relative polarity
5
Odor
faint pleasant odor
Water Solubility 
H2O: 1 M at 20 °C, miscible
Merck 
14,9230
BRN 
773898
Dielectric constant
24.460000000000001
InChIKey
AVQQQNCBBIEMEU-UHFFFAOYSA-N
CAS DataBase Reference
632-22-4(CAS DataBase Reference)
NIST Chemistry Reference
Urea, tetramethyl-(632-22-4)
EPA Substance Registry System
Tetramethylurea (632-22-4)
More
Less

Safety

Hazard Codes 
Xn,T
Risk Statements 
22-61
Safety Statements 
53-45
RIDADR 
NA 1993 / PGIII
WGK Germany 
3
RTECS 
YU2625000
F 
3-10
TSCA 
Yes
HS Code 
29241900
Hazardous Substances Data
632-22-4(Hazardous Substances Data)
Toxicity
LD50 i.v. in rats: 1.1 g/kg (Lüttringhaus, Dirksen)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T24503
Product name
Tetramethylurea
Purity
99%
Packaging
5g
Price
$29
Updated
2024/03/01
TCI Chemical
Product number
T0158
Product name
Tetramethylurea
Purity
>98.0%(GC)
Packaging
25g
Price
$26
Updated
2024/03/01
TCI Chemical
Product number
T0158
Product name
Tetramethylurea
Purity
>98.0%(GC)
Packaging
500g
Price
$191
Updated
2024/03/01
Alfa Aesar
Product number
A16295
Product name
Tetramethylurea
Purity
99%
Packaging
50g
Price
$42.8
Updated
2024/03/01
Alfa Aesar
Product number
A16295
Product name
Tetramethylurea
Purity
99%
Packaging
250g
Price
$147
Updated
2024/03/01
More
Less

1,1,3,3-Tetramethylurea Chemical Properties,Usage,Production

Chemical Properties

Tetramethylurea is a clear colorless to pale yellow liquid with mild aromatic odor that is miscible with water and many organic solvents. Unusual for an urea is the liquid state of tetramethylurea in a range of > 170 °C.

Uses

Tetramethylurea is used as a solvent in dyestuff industries, in condensation reaction and intermediates in surfactant. It is utilized for base catalyzed isomerization and alkylation hydrocyanation due to its low permittivity. It reacts with oxalyl chloride to prepare tetramethyl chloroformamidinium chloride, which is used for the conversion of carboxylic acids and dialkyl phosphates to anhydrides and pyrophosphates respectively.

Definition

ChEBI: 1,1,3,3-tetramethylurea is a member of the class of ureas that is urea substituted by methyl groups at positions 1, 1, 3 and 3 respectively. Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Preparation

The reaction of dimethylamine with phosgene in the presence of e. g. 50 % sodium hydroxide solution and subsequent extraction with 1,2-dichloroethane yields tetramethylurea in 95% yield.

Safety Profile

Moderately toxic by ingestion and intravenous routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. Combustible when exposed to heat, flame, and oxidizers. To fight fire, use foam, mist, spray, dry chemicals. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Dry it over BaO and distil it under nitrogen. It denatures proteins in H2O. [Elbaum & Herskovits Biochemistry 13 1268 1974, Kane Anal Biochem 53 350 1973, Beilstein 4 IV 225.]

1,1,3,3-Tetramethylurea Preparation Products And Raw materials

Raw materials

Preparation Products

Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate
More
Less

1,1,3,3-Tetramethylurea Suppliers

Belgium 2 Canada 1 CHINA 267 Europe 4 France 2 Germany 7 India 7 Japan 7 Slovakia 1 South Korea 1 Switzerland 3 Ukraine 1 United Kingdom 11 United States 39 Global 353
Suzhou Highfine Biotech Co., Ltd
Tel
0512-68311833 13962195826
Fax
0512-68417696
Email
wuhao@highfine.com
Country
China
ProdList
498
Advantage
75
Shandong Dexin Fine Chemical Co. LTD
Tel
18353358123 18353358123
Email
839877395@qq.com
Country
China
ProdList
151
Advantage
58
Henan Guangwo New Materials Co., Ltd
Tel
15225201380 18336995067
Email
3656693041@qq.com
Country
China
ProdList
1721
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40240
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12458
Advantage
60
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11660
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
Country
China
ProdList
42982
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
Advantage
52
Shandong Xiya Chemical Co., Ltd
Tel
13355009207 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18739
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11714
Advantage
57
ZhengZhou HuaWen Chemical Co.Ltd
Tel
0370-2785118 15343847665
Fax
QQ：3470079902
Email
huawenchem@163.com
Country
China
ProdList
3205
Advantage
55
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9664
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9900
Advantage
58
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
4969
Advantage
50
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6139
Advantage
55
Beijing Comparison Pharmaceutical Technology Co., Ltd
Tel
010-52878169 15701683040
Email
sales@bjcomparison.com
Country
China
ProdList
4693
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19918
Advantage
55
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
18017383231 18017383231
Fax
qq：2817624287
Email
lyh_antaeus@163.com
Country
China
ProdList
9352
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22519
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25014
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9552
Advantage
55
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9986
Advantage
55
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4928
Advantage
55
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
Shanghai DiBai Chemicals Co., Ltd.
Tel
021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3993
Advantage
60
RiZhao LiDeShi Chemical Co., Ltd.
Tel
010-51268198
Fax
010-63833209
Email
leadershipchem@126.com
Country
China
ProdList
2549
Advantage
58
Mei Lan Industrial (Shanghai) Co., Ltd.
Tel
021-58958189
Fax
021-58957967
Email
wouchina@126.com
Country
China
ProdList
2671
Advantage
55
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17994
Advantage
56
Shanghai ideal Industrial Co., Ltd.
Tel
021-58957966 18930537195
Fax
021-60899437
Email
wouchina@126.com
Country
China
ProdList
3033
Advantage
58
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13359
Advantage
58
GuangTuo Chemical (Shanghai) Co., Ltd.
Tel
021-60899189-8001 18918189673
Fax
021-60899304
Email
gtchem@126.com
Country
China
ProdList
2661
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15185
Advantage
58
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5223
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15878
Advantage
55
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9911
Advantage
50
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.
Tel
021-69106960 13701823733
Fax
021-69106780
Email
13701823733@163.com
Country
China
ProdList
4775
Advantage
60
Hangzhou J&H Chemical Co., Ltd.
Tel
+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
10015
Advantage
53
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8147
Advantage
55
Beijing Xinsavi Chemical Technology Co., Ltd.
Tel
010-56218822 13717722232
Fax
010-56218800
Email
xinsavichem@163.com
Country
China
ProdList
3201
Advantage
56
More
Less

View Lastest Price from 1,1,3,3-Tetramethylurea manufacturers

Hebei Duling International Trade Co. LTD
Product
1,1,3,3-Tetramethylurea 632-22-4
Price
US $56.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 tons
Release date
2023-04-03
Hebei Mojin Biotechnology Co., Ltd
Product
1,1,3,3-Tetramethylurea 632-22-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20tons
Release date
2023-08-15
Hebei Guanlang Biotechnology Co., Ltd.
Product
1,1,3,3-Tetramethylurea 632-22-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2023-01-04

632-22-4, 1,1,3,3-TetramethylureaRelated Search:

4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one PIPERAZINE DIHYDROCHLORIDE 3-((4-Oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid 1-Hydroxybenzotriazole Olaparib Impurity 14 5-Bromo-2-fluorobenzonitrile Cyclopropanecarbonyl Chloride 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzonitrile 2-Propanone, 1-[4,5-dihydro-2-(4-methyl-1-piperazinyl)-4-thioxo-3H-1,5-benzodiazepin-3-ylidene]- Olaparib Impurity 31 Olaparib Impurity 30 tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoyl)piperazine-1-carboxylate 2,2'-Oxybis(nitrobenzene) Olaparib Impurity 25 2,2'-OXYDIANILINE Olaparib Impurity 15 tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate tert-Butyl 1-piperazinecarboxylate

  • TETRAMETHYLUREA
  • N,N,N',N'-TETRAMETHYLUREA
  • ((CH3)2N)2CO
  • 1,1,3,3-tetramethyl-ure
  • Temur
  • Tetramethylharnstoff
  • tetramethyl-ure
  • Tetramethyluree
  • Four Methylurea
  • TetraMethylurea, 99.5%
  • TMU
  • 1,1,3,3-TETRAMETHYLUREA
  • Urea,N,N,N',N'-tetramethyl-
  • Olaparib Impurity 38
  • 1,1,3,3-Tetramethylurea, TMU
  • 1,1,3,3-Tetramethylurea, Tetramethylurea, TMU
  • 1,1,3,3-Tetramethylurea, 99+%, nonaqueous titration grade
  • 1,1,3,3-Tetramethylurea, nonaqueous titration grade
  • 1,1,3,3-Tetramethylurea,99%
  • Tetramethylurea,1,1,3,3-Tetramethylurea, TMU
  • 1,1,3,3-TetraMethylurea, 99% 100ML
  • Urea, 1,1,3,3-tetramethyl-
  • urea,1,1,3,3-tetramethyl-
  • 1,1,3,3-Tetramethylurea Tetramethylurea Temur
  • 1,1,3,3-Tetramethylurea, nonaqueous titration grade, 99+%
  • Urea, tetramethyl-
  • TERAMETHYLUREA
  • TETRAMETHYLUREA FOR SYNTHESIS
  • NSC 91488
  • Tetramethylurea&gt
  • Tetramethylurea, 99%, for synthesis
  • Olaparib Imp.38
  • Tetramethylurea,>99%
  • Olaparib Impurity 17 (Tetramethylurea)
  • Tetramethyl urea (TMU)
  • Sitagliptin Impurity 138
  • Olapali impurity 24
  • 632-22-4
  • CH32NCONCH32
  • Organic Building Blocks
  • Ureas
  • Building Blocks
  • Carbonyl Compounds
  • Miscellaneous
  • Building Blocks
  • Carbonyl Compounds
  • Chemical Synthesis
  • Organic Building Blocks
  • Ureas
  • Bioactive Small Molecules
  • Cell Biology
  • T
  • 1
  • bc0001