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5-Bromo-2-fluorobenzonitrile

Product Name
5-Bromo-2-fluorobenzonitrile
CAS No.
179897-89-3
Chemical Name
5-Bromo-2-fluorobenzonitrile
Synonyms
2-Fluoro-5-bromobenzonitrile;Olapali impurity 6;Olapali impurity 17;2- fluorine-5-broMoxynil;5-BROMO-2-FLUOROBENZONITRILE;2-Flouro-5-bromobenzonitrile;2-Fliuoro-5-broMo Benzonitrile;Benzonitrile, 5-broMo-2-fluoro-;5-Bromo-2-fluorobenzonitrile98%;5-Bromo-2-fluorobenzonitrile >
CBNumber
CB3431412
Molecular Formula
C7H3BrFN
Formula Weight
200.01
MOL File
179897-89-3.mol
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5-Bromo-2-fluorobenzonitrile Property

Melting point:
76-81 °C
Boiling point:
220.4±20.0 °C(Predicted)
Density 
1.7286 (rough estimate)
refractive index 
1.5320 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
color 
White to Light yellow to Light orange
BRN 
7701063
InChI
InChI=1S/C7H3BrFN/c8-6-1-2-7(9)5(3-6)4-10/h1-3H
InChIKey
GYCNHFWRPJXTSB-UHFFFAOYSA-N
SMILES
C(#N)C1=CC(Br)=CC=C1F
CAS DataBase Reference
179897-89-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,T,Xi
Risk Statements 
36/37/38-20/21/22
Safety Statements 
36/37/39-26-22-36
RIDADR 
3439
WGK Germany 
3
Hazard Note 
Toxic
HazardClass 
6.1
PackingGroup 
III
HS Code 
29269090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
465259
Product name
5-Bromo-2-fluorobenzonitrile
Purity
97%
Packaging
5g
Price
$18.72
Updated
2024/03/01
Sigma-Aldrich
Product number
465259
Product name
5-Bromo-2-fluorobenzonitrile
Purity
97%
Packaging
1g
Price
$28.6
Updated
2023/06/20
TCI Chemical
Product number
B2425
Product name
5-Bromo-2-fluorobenzonitrile
Purity
>98.0%(GC)
Packaging
5g
Price
$29
Updated
2024/03/01
TCI Chemical
Product number
B2425
Product name
5-Bromo-2-fluorobenzonitrile
Purity
>98.0%(GC)
Packaging
25g
Price
$113
Updated
2024/03/01
Alfa Aesar
Product number
A16113
Product name
5-Bromo-2-fluorobenzonitrile, 98%
Packaging
5g
Price
$44.65
Updated
2024/03/01
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5-Bromo-2-fluorobenzonitrile Chemical Properties,Usage,Production

Chemical Properties

white to off-white powder or crystals

Uses

5-Bromo-2-fluorobenzonitrile may be used for the preparation of the following compounds:

  • (E)-5-(2-cyclopropylvinyl)-2-fluorobenzonitrile and methyl-3-amino-5-bromobenzo[b]thiophene-2-carboxylate
  • (S)-[2-[5-(3-cyano-4-fluoro-phenyl)-pyridin-3-yloxy]-1-(1H-indol-3-ylmethyl)-ethyl]-carbamic acid tert-butyl ester
  • 4-fluoro-3-cyano-3′-tributyltinbenzhydrol
  • 4-fluoro-3-cyano-3′-iodobenzhydrol

Synthesis

5-Bromo-2-fluorobenzonitrile is the key intermediate of the synthetic antigout drug Febuxostat. The synthesis method comprises the following steps: reacting o-fluorobenzoyl chloride with ammonia water to obtain o-fluorobenzamide; then generating o-fluorobenzonitrile under the action of a dehydration reagent; and finally, in 75-90% sulfuric acid, brominating with dibromohydantoin to obtain 5-bromo-2-fluorobenzonitrile. The synthesis method is simple and easy to implement, mild in conditions, low in production cost, and causes no wastewater discharge.

5-Bromo-2-fluorobenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-2-fluorobenzonitrile Suppliers

Shanghai Harvest Chemical Industrial Co., Ltd.
Tel
21-31038972 15721252604
Fax
+86-21-51385350
Email
ammyzuo@harvest-chem.com
Country
China
ProdList
2540
Advantage
64
Shanghai Xiannuo Biotechnology Co., Ltd.
Tel
021-50718719 13918719472
Fax
021-50718719
Country
China
ProdList
979
Advantage
58
CE Pharm Co.,Ltd
Tel
15317222985
Fax
binbin.lin@cepharm.cn
Email
bingna.wang@cepharm.cn
Country
China
ProdList
142
Advantage
58
Henan yingchuang
Tel
16650708709
Fax
qq:778660296
Email
hnyingchuang@163.com
Country
China
ProdList
3924
Advantage
58
Lianhe Aigen Pharmatech Co.,Ltd.
Tel
18918657159
Email
sales-Aigen@lianhetech.com
Country
China
ProdList
3023
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
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View Lastest Price from 5-Bromo-2-fluorobenzonitrile manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
5-Bromo-2-fluorobenzonitrile 179897-89-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28
Hebei Yanxi Chemical Co., Ltd.
Product
5-Bromo-2-fluorobenzonitrile 179897-89-3
Price
US $10.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-21
PNP Biotech Co. Ltd
Product
5-Bromo-2-fluorobenzonitrile 179897-89-3
Price
US $0.00/KG
Min. Order
25KG
Purity
95%
Supply Ability
Inquiry
Release date
2022-09-22

179897-89-3, 5-Bromo-2-fluorobenzonitrileRelated Search:


  • Benzonitrile, 5-broMo-2-fluoro-
  • 2- fluorine-5-broMoxynil
  • 2-Fliuoro-5-broMo Benzonitrile
  • 5-Bromo-2-fluorobenzonitrile,97%
  • 5-BROMO-2-FLUOROBENZONITRILE
  • 2-Fluoro-5-bromobenzonitrile
  • 5-Bromo-2-fluorobenzonitrile 98%
  • 5-Bromo-2-fluorobenzonitrile98%
  • 5-Bromo-2-fluorobenzonitrile &gt
  • 5-Bromo-2-fluorobenzonitrile (Olaparib Impurity)
  • Olapali impurity 17
  • 2-Flouro-5-bromobenzonitrile
  • Olapali impurity 6
  • 179897-89-3
  • Cyanides/Nitriles
  • Organic Building Blocks
  • Nitrogen Compounds
  • ARYL HALIDE
  • Building Blocks
  • C6 to C7
  • cyanide| alkyl bromide| alkyl Fluorine
  • Fluorine series
  • Febuxostat
  • Aromatic Nitriles
  • Nitrile
  • Miscellaneous
  • Bromine Compounds
  • Fluorine Compounds
  • Nitriles
  • C6 to C7
  • Cyanides/Nitriles
  • Nitrogen Compounds
  • Fluorobenzene