1,1,3,3-Tetramethylurea

Product Name: 1,1,3,3-Tetramethylurea
CAS No.: 632-22-4
Chemical Name: 1,1,3,3-Tetramethylurea
Synonyms: TMU;TETRAMETHYLUREA;Urea, tetramethyl-;Temur;tetramethyl-ure;1,1,3,3-tetramethyl-ure;NSC 91488;((CH3)2N)2CO;TERAMETHYLUREA;Four Methylurea
CBNumber: CB1309805
Molecular Formula: C5H12N2O
Formula Weight: 116.16
MOL File: 632-22-4.mol

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1,1,3,3-Tetramethylurea Property

Melting point:: −1 °C(lit.)
Boiling point:: 177 °C(lit.)
Density: 0.968 g/mL at 20 °C(lit.)
refractive index: n20/D 1.451(lit.)
Flash point:: 150 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: Miscible with water, petroleum ether and common solvents.
form: Liquid
pka: 2.0(at 25℃)
color: Clear colorless to pale yellow
PH: 5-8 (25℃, 1M in H2O)
Relative polarity: 5
Odor: faint pleasant odor
Water Solubility: H2O: 1 M at 20 °C, miscible
Merck: 14,9230
BRN: 773898
Dielectric constant: 24.460000000000001
InChIKey: AVQQQNCBBIEMEU-UHFFFAOYSA-N
CAS DataBase Reference: 632-22-4(CAS DataBase Reference)
NIST Chemistry Reference: Urea, tetramethyl-(632-22-4)
EPA Substance Registry System: Tetramethylurea (632-22-4)

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Safety

Hazard Codes: Xn,T
Risk Statements: 22-61
Safety Statements: 53-45
RIDADR: NA 1993 / PGIII
WGK Germany: 3
RTECS: YU2625000
F: 3-10
TSCA: Yes
HS Code: 29241900
Hazardous Substances Data: 632-22-4(Hazardous Substances Data)
Toxicity: LD50 i.v. in rats: 1.1 g/kg (Lüttringhaus, Dirksen)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T24503
Product name: Tetramethylurea
Purity: 99%
Packaging: 5g
Price: $29
Updated: 2024/03/01

TCI Chemical

Product number: T0158
Product name: Tetramethylurea
Purity: >98.0%(GC)
Packaging: 25g
Price: $26
Updated: 2024/03/01

TCI Chemical

Product number: T0158
Product name: Tetramethylurea
Purity: >98.0%(GC)
Packaging: 500g
Price: $191
Updated: 2024/03/01

Alfa Aesar

Product number: A16295
Product name: Tetramethylurea
Purity: 99%
Packaging: 50g
Price: $42.8
Updated: 2024/03/01

Alfa Aesar

Product number: A16295
Product name: Tetramethylurea
Purity: 99%
Packaging: 250g
Price: $147
Updated: 2024/03/01

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1,1,3,3-Tetramethylurea Chemical Properties,Usage,Production

Chemical Properties

Tetramethylurea is a clear colorless to pale yellow liquid with mild aromatic odor that is miscible with water and many organic solvents. Unusual for an urea is the liquid state of tetramethylurea in a range of > 170 °C.

Uses

Tetramethylurea is used as a solvent in dyestuff industries, in condensation reaction and intermediates in surfactant. It is utilized for base catalyzed isomerization and alkylation hydrocyanation due to its low permittivity. It reacts with oxalyl chloride to prepare tetramethyl chloroformamidinium chloride, which is used for the conversion of carboxylic acids and dialkyl phosphates to anhydrides and pyrophosphates respectively.

Definition

ChEBI: 1,1,3,3-tetramethylurea is a member of the class of ureas that is urea substituted by methyl groups at positions 1, 1, 3 and 3 respectively. Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Preparation

The reaction of dimethylamine with phosgene in the presence of e. g. 50 % sodium hydroxide solution and subsequent extraction with 1,2-dichloroethane yields tetramethylurea in 95% yield.

Safety Profile

Moderately toxic by ingestion and intravenous routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. Combustible when exposed to heat, flame, and oxidizers. To fight fire, use foam, mist, spray, dry chemicals. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Dry it over BaO and distil it under nitrogen. It denatures proteins in H2O. [Elbaum & Herskovits Biochemistry 13 1268 1974, Kane Anal Biochem 53 350 1973, Beilstein 4 IV 225.]

Toxics Screening Level

The initial threshold screening level (ITSL) for tetramethylurea is 0.8 μg/m3 based on an annual averaging time and 230 μg/m3 based on a 24-hour averaging time.

1,1,3,3-Tetramethylurea Preparation Products And Raw materials

Raw materials

Preparation Products

Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate

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1,1,3,3-Tetramethylurea Suppliers

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View Lastest Price from 1,1,3,3-Tetramethylurea manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: 1,1,3,3-Tetramethylurea 632-22-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20tons
Release date: 2023-08-15

Shaanxi Dideu New Materials Co. Ltd

Product: 1,1,3,3-Tetramethylurea 632-22-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-25

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1,1,3,3-Tetramethylurea 632-22-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-09

632-22-4, 1,1,3,3-TetramethylureaRelated Search:

4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one PIPERAZINE DIHYDROCHLORIDE 3-((4-Oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid 1-Hydroxybenzotriazole Olaparib Impurity 14 5-Bromo-2-fluorobenzonitrile Cyclopropanecarbonyl Chloride 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzonitrile 2-Propanone, 1-[4,5-dihydro-2-(4-methyl-1-piperazinyl)-4-thioxo-3H-1,5-benzodiazepin-3-ylidene]- Olaparib Impurity 31 Olaparib Impurity 30 tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoyl)piperazine-1-carboxylate 2,2'-Oxybis(nitrobenzene) Olaparib Impurity 25 2,2'-OXYDIANILINE Olaparib Impurity 15 tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate tert-Butyl 1-piperazinecarboxylate

TETRAMETHYLUREA

N,N,N',N'-TETRAMETHYLUREA

((CH3)2N)2CO

1,1,3,3-tetramethyl-ure

Temur

Tetramethylharnstoff

tetramethyl-ure

Tetramethyluree

Four Methylurea

TetraMethylurea, 99.5%

TMU

1,1,3,3-TETRAMETHYLUREA

Urea,N,N,N',N'-tetramethyl-

Olaparib Impurity 38

1,1,3,3-Tetramethylurea, TMU

1,1,3,3-Tetramethylurea, Tetramethylurea, TMU

1,1,3,3-Tetramethylurea, 99+%, nonaqueous titration grade

1,1,3,3-Tetramethylurea, nonaqueous titration grade

1,1,3,3-Tetramethylurea,99%

Tetramethylurea,1,1,3,3-Tetramethylurea, TMU

1,1,3,3-TetraMethylurea, 99% 100ML

Urea, 1,1,3,3-tetramethyl-

urea,1,1,3,3-tetramethyl-

1,1,3,3-Tetramethylurea Tetramethylurea Temur

1,1,3,3-Tetramethylurea, nonaqueous titration grade, 99+%

Urea, tetramethyl-

TERAMETHYLUREA

TETRAMETHYLUREA FOR SYNTHESIS

NSC 91488

Tetramethylurea&gt

Tetramethylurea, 99%, for synthesis

Olaparib Imp.38

Tetramethylurea,>99%

Olaparib Impurity 17 (Tetramethylurea)

Tetramethyl urea (TMU)

Sitagliptin Impurity 138

Olapali impurity 24

632-22-4

CH32NCONCH32

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