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Lusutrombopag

Product Name
Lusutrombopag
CAS No.
1110766-97-6
Chemical Name
Lusutrombopag
Synonyms
S888711;S 888711;Rutroppa;Luso Qubopa;Lusuo Quboppa;S888711;S 888711;Lusutrombopag S-888711;Lusutrombopag, 10 mM in DMSO;Lusutrombopag,inhibit,Inhibitor,S888711,S 888711,Thrombopoietin Receptor;(E)-3-[2,6-dichloro-4-[4-[3-[(S)-1-hexyloxyethyl]-2-methoxyphenyl]thiazol-2-ylcarbamoyl]phenyl]-2-methylacrylic acid
CBNumber
CB13133177
Molecular Formula
C29H32Cl2N2O5S
Formula Weight
591.55
MOL File
1110766-97-6.mol
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Lusutrombopag Property

Density 
1.299±0.06 g/cm3(Predicted)
storage temp. 
Store at 0-8 °C
solubility 
DMSO: 30 mg/ml
form 
A crystalline solid
pka
4.33±0.21(Predicted)
color 
White to off-white
InChIKey
NOZIJMHMKORZBA-KJCUYJGMSA-N
SMILES
C(O)(=O)/C(/C)=C/C1=C(Cl)C=C(C(NC2=NC(C3=CC=CC([C@@H](OCCCCCC)C)=C3OC)=CS2)=O)C=C1Cl
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26533
Product name
Lusutrombopag
Packaging
1mg
Price
$45
Updated
2024/03/01
Cayman Chemical
Product number
26533
Product name
Lusutrombopag
Packaging
50mg
Price
$1092
Updated
2024/03/01
Cayman Chemical
Product number
26533
Product name
Lusutrombopag
Packaging
5mg
Price
$198
Updated
2024/03/01
Cayman Chemical
Product number
26533
Product name
Lusutrombopag
Packaging
10mg
Price
$351
Updated
2024/03/01
TRC
Product number
L474985
Product name
Lusutrombopag
Packaging
10mg
Price
$400
Updated
2021/12/16
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Lusutrombopag Chemical Properties,Usage,Production

Uses

Lusutrombopag is a newly discovered thrombopoietin receptor agonist used in the treatment of patients with chronic ITP.

Definition

ChEBI: Lusutrombopag is a member of cinnamic acids.

Mechanism of action

Lusutrombopag acts selectively on the human TPO receptor and activates signal transduction pathways that promote the proliferation and differentiation of bone marrow cells into megakaryocytes, thereby increasing platelet levels.

Synthesis

1110768-00-7

1110766-97-6

GENERAL STEPS: In a three-necked flask equipped with a mechanical stirrer, 100 mL of tetrahydrofuran (THF) and 25.2 g (40.7 mmol) of ethyl (S,E)-3-(2,6-dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methacrylate were added. Subsequently, 1.64 g of sodium hydroxide and 100 mL of water were added and the reaction mixture was heated to 60 °C with continuous stirring for 5 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming complete consumption of the raw materials, the reaction mixture was cooled to room temperature. Most of the organic solvent was evaporated under reduced pressure and then the pH was adjusted to 2-3 by slow dropwise addition of 2 N dilute hydrochloric acid, at which point a yellow solid precipitated. The solid product was collected by filtration and washed 2-3 times with methyl tert-butyl ether to give finally (S,E)-3-(2,6-dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylic acid in white solid powder form in a yield of 23.8 g and 99% yield.

References

[1] Patent: CN106083759, 2016, A. Location in patent: Paragraph 0012

Lusutrombopag Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Lusutrombopag manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Lusutrombopag 1110766-97-6
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-11-15
Henan Fengda Chemical Co., Ltd
Product
Lusutrombopag 1110767-00-7
Price
US $10.00-3.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-05-13
Career Henan Chemical Co
Product
Lusutrombopag 1110766-97-6
Price
US $2000.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10kg
Release date
2018-08-02

1110766-97-6, LusutrombopagRelated Search:

Unii-4U07F515lg Avatrombopag Eltrombopag Avatrombopag maleate Ibopamine Hydrochloride 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine

  • Lusutrombopag S-888711
  • (E)-3-[2,6-dichloro-4-[4-[3-[(S)-1-hexyloxyethyl]-2-methoxyphenyl]thiazol-2-ylcarbamoyl]phenyl]-2-methylacrylic acid
  • S 888711
  • S888711
  • S888711;S 888711
  • 2-Propenoic acid, 3-[2,6-dichloro-4-[[[4-[3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-, (2E)-
  • Lusutrombopag,inhibit,Inhibitor,S888711,S 888711,Thrombopoietin Receptor
  • Rutroppa
  • Lusutrombopag, 10 mM in DMSO
  • Luso Qubopa
  • Lusuo Quboppa
  • 1110766-97-6
  • API