Lusutrombopag

Product Name: Lusutrombopag
CAS No.: 1110766-97-6
Chemical Name: Lusutrombopag
Synonyms: S888711;S 888711;Rutroppa;Luso Qubopa;Lusuo Quboppa;S888711;S 888711;Lusutrombopag S-888711;Lusutrombopag, 10 mM in DMSO;Lusutrombopag,inhibit,Inhibitor,S888711,S 888711,Thrombopoietin Receptor;(E)-3-[2,6-dichloro-4-[4-[3-[(S)-1-hexyloxyethyl]-2-methoxyphenyl]thiazol-2-ylcarbamoyl]phenyl]-2-methylacrylic acid
CBNumber: CB13133177
Molecular Formula: C29H32Cl2N2O5S
Formula Weight: 591.55
MOL File: 1110766-97-6.mol

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Lusutrombopag Property

Density: 1.299±0.06 g/cm3(Predicted)
storage temp.: Store at 0-8 °C
solubility: DMSO: 30 mg/ml
form: A crystalline solid
pka: 4.33±0.21(Predicted)
color: White to off-white
InChIKey: NOZIJMHMKORZBA-KJCUYJGMSA-N
SMILES: C(O)(=O)/C(/C)=C/C1=C(Cl)C=C(C(NC2=NC(C3=CC=CC([C@@H](OCCCCCC)C)=C3OC)=CS2)=O)C=C1Cl

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26533
Product name: Lusutrombopag
Packaging: 1mg
Price: $45
Updated: 2024/03/01

Cayman Chemical

Product number: 26533
Product name: Lusutrombopag
Packaging: 50mg
Price: $1092
Updated: 2024/03/01

Cayman Chemical

Product number: 26533
Product name: Lusutrombopag
Packaging: 5mg
Price: $198
Updated: 2024/03/01

Cayman Chemical

Product number: 26533
Product name: Lusutrombopag
Packaging: 10mg
Price: $351
Updated: 2024/03/01

TRC

Product number: L474985
Product name: Lusutrombopag
Packaging: 10mg
Price: $400
Updated: 2021/12/16

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Lusutrombopag Chemical Properties,Usage,Production

Uses

Lusutrombopag is a newly discovered thrombopoietin receptor agonist used in the treatment of patients with chronic ITP.

Definition

ChEBI: Lusutrombopag is a member of cinnamic acids.

Mechanism of action

Lusutrombopag acts selectively on the human TPO receptor and activates signal transduction pathways that promote the proliferation and differentiation of bone marrow cells into megakaryocytes, thereby increasing platelet levels.

Synthesis

1110768-00-7

1110766-97-6

GENERAL STEPS: In a three-necked flask equipped with a mechanical stirrer, 100 mL of tetrahydrofuran (THF) and 25.2 g (40.7 mmol) of ethyl (S,E)-3-(2,6-dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methacrylate were added. Subsequently, 1.64 g of sodium hydroxide and 100 mL of water were added and the reaction mixture was heated to 60 °C with continuous stirring for 5 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming complete consumption of the raw materials, the reaction mixture was cooled to room temperature. Most of the organic solvent was evaporated under reduced pressure and then the pH was adjusted to 2-3 by slow dropwise addition of 2 N dilute hydrochloric acid, at which point a yellow solid precipitated. The solid product was collected by filtration and washed 2-3 times with methyl tert-butyl ether to give finally (S,E)-3-(2,6-dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylic acid in white solid powder form in a yield of 23.8 g and 99% yield.

References

[1] Patent: CN106083759, 2016, A. Location in patent: Paragraph 0012

Lusutrombopag Preparation Products And Raw materials

Raw materials

Preparation Products

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Lusutrombopag Suppliers

China 125 India 4 United States 10 Global 139

SynZeal Research Pvt Ltd

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Country: India
ProdList: 6514
Advantage: 58

Pharma Affiliates

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Email: @pharmaffiliates.com
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ProdList: 6754
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Pharmaffiliates Analytics and Synthetics P. Ltd

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A.J Chemicals

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ProdList: 6100
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View Lastest Price from Lusutrombopag manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Lusutrombopag 1110766-97-6
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-11-15

Henan Fengda Chemical Co., Ltd

Product: Lusutrombopag 1110767-00-7
Price: US $10.00-3.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-05-13

Career Henan Chemical Co

Product: Lusutrombopag 1110766-97-6
Price: US $2000.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2018-08-02

1110766-97-6, LusutrombopagRelated Search:

Unii-4U07F515lg Avatrombopag Eltrombopag Avatrombopag maleate Ibopamine Hydrochloride 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine

Lusutrombopag S-888711

(E)-3-[2,6-dichloro-4-[4-[3-[(S)-1-hexyloxyethyl]-2-methoxyphenyl]thiazol-2-ylcarbamoyl]phenyl]-2-methylacrylic acid

S 888711

S888711

S888711;S 888711

2-Propenoic acid, 3-[2,6-dichloro-4-[[[4-[3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-, (2E)-

Lusutrombopag,inhibit,Inhibitor,S888711,S 888711,Thrombopoietin Receptor

Rutroppa

Lusutrombopag, 10 mM in DMSO

Luso Qubopa

Lusuo Quboppa

1110766-97-6

API