Lusutrombopag
- Product Name
- Lusutrombopag
- CAS No.
- 1110766-97-6
- Chemical Name
- Lusutrombopag
- Synonyms
- S888711;S 888711;Rutroppa;Luso Qubopa;Lusuo Quboppa;S888711;S 888711;Lusutrombopag S-888711;Lusutrombopag, 10 mM in DMSO;Lusutrombopag,inhibit,Inhibitor,S888711,S 888711,Thrombopoietin Receptor;(E)-3-[2,6-dichloro-4-[4-[3-[(S)-1-hexyloxyethyl]-2-methoxyphenyl]thiazol-2-ylcarbamoyl]phenyl]-2-methylacrylic acid
- CBNumber
- CB13133177
- Molecular Formula
- C29H32Cl2N2O5S
- Formula Weight
- 591.55
- MOL File
- 1110766-97-6.mol
Lusutrombopag Property
- Density
- 1.299±0.06 g/cm3(Predicted)
- storage temp.
- Store at 0-8 °C
- solubility
- DMSO: 30 mg/ml
- form
- A crystalline solid
- pka
- 4.33±0.21(Predicted)
- color
- White to off-white
- InChIKey
- NOZIJMHMKORZBA-KJCUYJGMSA-N
- SMILES
- C(O)(=O)/C(/C)=C/C1=C(Cl)C=C(C(NC2=NC(C3=CC=CC([C@@H](OCCCCCC)C)=C3OC)=CS2)=O)C=C1Cl
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 26533
- Product name
- Lusutrombopag
- Packaging
- 1mg
- Price
- $45
- Updated
- 2024/03/01
- Product number
- 26533
- Product name
- Lusutrombopag
- Packaging
- 50mg
- Price
- $1092
- Updated
- 2024/03/01
- Product number
- 26533
- Product name
- Lusutrombopag
- Packaging
- 5mg
- Price
- $198
- Updated
- 2024/03/01
- Product number
- 26533
- Product name
- Lusutrombopag
- Packaging
- 10mg
- Price
- $351
- Updated
- 2024/03/01
- Product number
- L474985
- Product name
- Lusutrombopag
- Packaging
- 10mg
- Price
- $400
- Updated
- 2021/12/16
Lusutrombopag Chemical Properties,Usage,Production
Uses
Lusutrombopag is a newly discovered thrombopoietin receptor agonist used in the treatment of patients with chronic ITP.
Definition
ChEBI: Lusutrombopag is a member of cinnamic acids.
Mechanism of action
Lusutrombopag acts selectively on the human TPO receptor and activates signal transduction pathways that promote the proliferation and differentiation of bone marrow cells into megakaryocytes, thereby increasing platelet levels.
Synthesis
1110768-00-7
1110766-97-6
GENERAL STEPS: In a three-necked flask equipped with a mechanical stirrer, 100 mL of tetrahydrofuran (THF) and 25.2 g (40.7 mmol) of ethyl (S,E)-3-(2,6-dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methacrylate were added. Subsequently, 1.64 g of sodium hydroxide and 100 mL of water were added and the reaction mixture was heated to 60 °C with continuous stirring for 5 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming complete consumption of the raw materials, the reaction mixture was cooled to room temperature. Most of the organic solvent was evaporated under reduced pressure and then the pH was adjusted to 2-3 by slow dropwise addition of 2 N dilute hydrochloric acid, at which point a yellow solid precipitated. The solid product was collected by filtration and washed 2-3 times with methyl tert-butyl ether to give finally (S,E)-3-(2,6-dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylic acid in white solid powder form in a yield of 23.8 g and 99% yield.
References
[1] Patent: CN106083759, 2016, A. Location in patent: Paragraph 0012
Lusutrombopag Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Lusutrombopag manufacturers
- Product
- Lusutrombopag 1110766-97-6
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-11-15
- Product
- Lusutrombopag 1110767-00-7
- Price
- US $10.00-3.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-05-13
- Product
- Lusutrombopag 1110766-97-6
- Price
- US $2000.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2018-08-02