(S)-2-Aminotetralin

Product Name: (S)-2-Aminotetralin
CAS No.: 21880-87-5
Chemical Name: (S)-2-Aminotetralin
Synonyms: (S)-1-AMINOTETRALIN;(S)-2-AMINOTETRALIN;(2S)-tetralin-2-amine;(S)-(+)-1-AMINOTETRALIN;(S)-(-)-1-AMINOTETRALIN;(S)-(-)-2-AMINOTETRALIN;(S)-1,2,3,4-TETRAHYDRO-1-NAPHTHYLAMINE;(S)-1,2,3,4-Tetrahydro-2-naphthylamine;(S)-1,2,3,4-Tetrahydronaphthalen-2-amine;(S)-1,2,3,4-TETRAHYDRONAPHTHALEN-1-AMINE
CBNumber: CB1313785
Molecular Formula: C10H13N
Formula Weight: 147.22
MOL File: 21880-87-5.mol

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(S)-2-Aminotetralin Property

Boiling point:: 246-247°C
Density: 1.023±0.06 g/cm3(Predicted)
Flash point:: >110°C
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 10.50±0.20(Predicted)
Appearance: Colorless to light yellow Liquid
optical activity: -73.8°(C=0.01g/ml CHCL3)
CAS DataBase Reference: 21880-87-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC

Product number: T796398
Product name: (S)-1,2,3,4-Tetrahydronaphthalen-2-amine
Packaging: 25mg
Price: $200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0016027
Product name: (S)-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE
Purity: 95.00%
Packaging: 1G
Price: $908.36
Updated: 2021/12/16

Matrix Scientific

Product number: 131973
Product name: (S)-1,2,3,4-Tetrahydronaphthalen-2-amine
Purity: 97%
Packaging: 5g
Price: $1617
Updated: 2021/12/16

AK Scientific

Product number: 1283AL
Product name: (S)-2-Aminotetralin
Packaging: 5g
Price: $1757
Updated: 2021/12/16

Matrix Scientific

Product number: 131973
Product name: (S)-1,2,3,4-Tetrahydronaphthalen-2-amine
Purity: 97%
Packaging: 10g
Price: $2880
Updated: 2021/12/16

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(S)-2-Aminotetralin Chemical Properties,Usage,Production

Uses

(S)-1,2,3,4-Tetrahydronaphthalen-2-amine is used in the synthesis of glucose uptake inhibitors.

Synthesis

530-93-8

2217-42-7

The generalized procedure for the synthesis of the target compounds from β-tetralone was as follows: the final concentration of the reaction system was 0.25 μL, which was adjusted using 100 mM potassium phosphate (KPi) buffer at pH 7.5, and an equimolar amount of 70 mM of the amino donor was reacted with 70 mM of the ketone substrate in 0.1 mL of the cell free extract (CFE) containing the transcripts for 24 hours at 28°C. Specific operations include: co-warming CFE containing transaminases XP-001209325, AAN21261, and ABN35871, respectively, with benzylacetone and α-methylbenzylamine to form 4-phenyl-2-butylamine and acetophenone; reaction of phenylacetone and α-methylbenzylamine to form α-ethylbenzylamine and acetophenone; reaction of 1-indanone and α-methylbenzylamine to form 1-aminoindan and acetophenone; the reaction of 1-tetralone and α-methylbenzylamine to form 1-aminotetralone and acetophenone; the reaction of 2-tetralone and α-methylbenzylamine to form 2-aminotetralone and acetophenone; the reaction of butanone and α-methylbenzylamine to form 2-amino-butane and acetophenone; and the reaction of 3,3-dimethyl-2-butanone and α-methylbenzylamine to form, respectively, 3,3-dimethyl-2-amino-butane and acetophenone. Reaction termination was achieved by adding 0.75 mL of termination reagent (50% (v/v) aqueous acetonitrile solution containing 0.1% (v/v) formic acid) to 0.25 mL of the reaction system. The product concentrations and enantiomeric excess values (e.e.) were analyzed by HPLC, and the results are detailed in Table 6.In addition, CFE containing transaminase YP-955297 was co-warmed with phenylacetone and α-methylbenzylamine, which similarly produced α-ethylbenzylamine and acetophenone. The reaction was terminated and analyzed as above. After warming at 28°C for 24 h, 0.87 mmol/L of (R)-α-ethylbenzylamine was obtained with a high e.e. value. The above results indicate that transaminases XP-001209325 and YP-955297 are highly selective (R)-transaminases. In addition, the substrate profiles of XP-001209325 and the transaminases AAN21261 and ABN35871 differed significantly: XP-001209325 significantly catalyzed the generation of 4-phenyl-2-butylamine, whereas AAN21261 and ABN35871 did not (Table 6). In addition, XP-001209325 catalyzed the generation of enantiomerically enriched (R)-2-aminobutane from 2-butanone, whereas ABN35871 generated enantiomerically enriched (S)-2-aminobutane (Table 6).

References

[1] ACS Catalysis, 2013, vol. 3, # 4, p. 555 - 559
[2] ACS Catalysis, 2013, vol. 3, # 4, p. 555 - 559
[3] Patent: US2016/32335, 2016, A1. Location in patent: Paragraph 0120; 0121; 0122

(S)-2-Aminotetralin Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-2-Aminotetralin Suppliers

China 66 France 1 Germany 3 India 2 Slovakia 1 United Kingdom 3 United States 16 Global 92

Alchem Pharmtech,Inc.

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View Lastest Price from (S)-2-Aminotetralin manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: (S)-2-Aminotetralin 21880-87-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: (S)-2-Aminotetralin 21880-87-5
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-30

21880-87-5, (S)-2-AminotetralinRelated Search:

ALTRENOGEST Tetramethylammonium hydroxide pentahydrate Tetrahydrothiophene cis-1,2,3,6-Tetrahydrophthalic anhydride 1,2,3,4-Tetrahydronaphthalene 2-Naphthylamine 6-Aminocaproic acid 3-Aminophenol Glycine beta-Tetralone 1-Naphthylamine Tetrahydrofuran Tris(hydroxymethyl)aminomethane DELTA9-TETRAHYDROCANNABINOL 6,7-Dihydroxy-2-aminotetralin (S)-1,2,3,4-Tetrahydro-1-naphthalenamine 5-Aminotetralin Hydrochloride,5,6,7,8-Tetrahydro-1-naphthylamine hydrochloride,1-Amino-5,6,7,8-tetrahydronaphthalene Hydrochloride 1,2,3,4-Tetrahydro-1-naphthylamine

(S)-2-Amino-1,2,3,4-tetrahydronaphthalene

(S)-1,2,3,4-Tetrahydro-1-napthylammonium salt

(S)-1,2,3,4-Tetrahydro-2-naphthylamine

(S)-1,2,3,4-Tetrahydronaphthalen-2-amine

2-Naphthalenamine,1,2,3,4-tetrahydro-, (2S)-

(2S)-1,2,3,4-tetrahydronaphthalen-2-amine

(S)-(-)-1-AMINOTETRALIN

(S)-(+)-1-AMINOTETRALIN

(S)-1-AMINOTETRALIN

(S)-(+)-1,2,3,4-TETRAHYDRO-1-NAPHTHYLAMINE

(S)-1,2,3,4-TETRAHYDRO-1-NAPHTHYLAMINE

(S)-1,2,3,4-TETRAHYDRONAPHTHALEN-1-AMINE

(S)-(1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YL)AMINE

(S)-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE

(S)-(-)-2-AMINOTETRALIN

(S)-2-AMINOTETRALIN

(2S)-tetralin-2-amine

(R)-2-amino-1-(2,5-dimethoxyphenyl)ethan-1-ol

21880-87-5

Asymmetric Synthesis

Chiral Building Blocks

Amines

Organic Building Blocks

Heterocyclic Compounds

chiral