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Dmt-2'fluoro-da(bz) amidite

Product Name
Dmt-2'fluoro-da(bz) amidite
CAS No.
136834-22-5
Chemical Name
Dmt-2'fluoro-da(bz) amidite
Synonyms
2’-F-dA(Bz) Amidite;2'-F-Bz-A Phosphoramidite;Bz-2'-F-dA Phosphoramidite;Dmt-2'fluoro-da(bz) amidite;Dmt-2'fluoro-da(bz) amidite;2'-F-N6-Bz-dA phosphoramidite;2'-F-Bz-dA-CE-Phosphoramidite;2'-F-dA(Bz)-CE Phosphoramidite;N6-Bz-5'-O-DMT-2'-fluoro-dA-CE;2'-F-dA(Bz)-CE-Phosphoramidite
CBNumber
CB13141318
Molecular Formula
C47H51FN7O7P
Formula Weight
875.92
MOL File
136834-22-5.mol
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Dmt-2'fluoro-da(bz) amidite Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
form 
Powder
pka
7.87±0.43(Predicted)
InChI
InChI=1/C47H51FN7O7P/c1-8-60-63(55(31(2)3)46(4,5)28-49)62-41-38(61-45(39(41)48)54-30-52-40-42(50-29-51-43(40)54)53-44(56)32-15-11-9-12-16-32)27-59-47(33-17-13-10-14-18-33,34-19-23-36(57-6)24-20-34)35-21-25-37(58-7)26-22-35/h9-26,29-31,38-39,41,45H,8,27H2,1-7H3,(H,50,51,53,56)/t38-,39-,41-,45-,63?/s3
InChIKey
ZDIBABNMVQPXHU-JWQXGDSTNA-N
SMILES
C(NC1C2=C(N=CN=1)N([C@H]1[C@H](F)[C@H](OP(OCC)N(C(C)C)C(C#N)(C)C)[C@@H](COC(C3=CC=C(OC)C=C3)(C3=CC=C(OC)C=C3)C3=CC=CC=C3)O1)C=N2)(=O)C1=CC=CC=C1 |&1:9,10,12,27,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J64064
Product name
N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-(2-cyanoethyl diisopropylphosphoramidite), 98%
Packaging
1g
Price
$123.65
Updated
2024/03/01
TRC
Product number
B208313
Product name
(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl(2-cyanoethyl)Diisopropylphosphoramidite
Packaging
1g
Price
$240
Updated
2021/12/16
AK Scientific
Product number
2404CT
Product name
Dmt-2'fluoro-da(bz)amidite
Packaging
500mg
Price
$151
Updated
2021/12/16
AK Scientific
Product number
2404CT
Product name
Dmt-2'fluoro-da(bz)amidite
Packaging
1g
Price
$218
Updated
2021/12/16
Biosynth Carbosynth
Product number
PB08393
Product name
N6-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoroadenosine 3'-CE phosphoramidite
Packaging
2g
Price
$220
Updated
2021/12/16
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Dmt-2'fluoro-da(bz) amidite Chemical Properties,Usage,Production

Chemical Properties

White to Light yellow powder to crystal.

Uses

(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (Dmt-2'fluoro-da(bz) amidite) is an adenosine derivative used in the preparation of modified nucleotides to improve metabolic stability and ellicit gene silencing, and in the synthesis of microRNA inhibitors.

Synthesis

3-((Bis(diisopropylamine)phosphanyl)oxy)propanenitrile (6.42 g, 21.3 mmol, 6.77 mL, 1.8 eq) was added to a solution of N-(9-((2R,3R,4R,5R)-5-((bis(4- methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-9H- purine-6-yl)benzamide (8.0 g, 11.8 mmol, 1.0 eq) in DCM (42 mL) at 0 °C followed by DCI (2.24 g, 18.9 mmol, 1.6 eq). The mixture was warmed to 25 °C and stirred for 3 hours. Two parallel reactions were carried out. The combined remedies were then diluted with DCM (150 mL), the organic layer was washed with sat NaHCO3 solution (200 mL) and brine (100 mL), dried over Na2SO4, filtered and concentrated, the crude was purified by column chromatography to give Dmt-2'fluoro-da(bz) amidite (18.0 g, 18.5 mmol, 78.1% yield, 90% purity) as a white solid.

Dmt-2'fluoro-da(bz) amidite Preparation Products And Raw materials

Raw materials

Preparation Products

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Dmt-2'fluoro-da(bz) amidite Suppliers

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View Lastest Price from Dmt-2'fluoro-da(bz) amidite manufacturers

SHANGHAI NOVRIBO BIOTECH
Product
2'-F-dA(Bz) CE Phosphoramidite 136834-22-5
Price
US $100.00/kg
Min. Order
0.009999999776482582kg
Purity
99%
Supply Ability
5tons
Release date
2023-03-21
Hefei Huana Biomedical Technology Co.,Ltd.
Product
N6-Bz-5'-O-DMT-2'-fluoro-dA-CE 136834-22-5
Price
US $0.00/mg
Min. Order
100mg
Purity
≥99%
Supply Ability
20tons
Release date
2023-03-09
Henan Aochuang Chemical Co.,Ltd.
Product
N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoroadenosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] 136834-22-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26

136834-22-5, Dmt-2'fluoro-da(bz) amiditeRelated Search:


  • N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoroadenosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • (2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
  • DMT-2'-F-dA(Bz)-CE Phosphoramidite
  • Bz-2'-F-dA Phosphoramidite
  • (2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite, >97%
  • 5'-Dimethoxytrityl-N-Benzoyl-2'-fluoro-3'-[(2-cyanoethyl)-(N,Ndiisopropyl)]-phosphoramidite-deoxyadenosine
  • N6-Benzoyl-5'-O-(4,4'-Dimethoxy trityl)-2'-deoxy-2'-fluoroadenosine-3'-O-[(2-cyanoethyl)-(N,N-diiso-propyl)]phosphoramidite
  • 5'-DMT-2'-F-Bz-dA Phosphoramidite
  • Dmt-2'fluoro-da(bz) amidite
  • 2'-F-dA(Bz)-CE Phosphoramidite
  • N6-Bz-5'-O-(4, 4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-CE-Phosphoramidite
  • Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite
  • 2'-F-N6-Bz-dA phosphoramidite
  • 2'-DEOXY-2'-FLUORO-N6Bz-ADENOSINE-3'-CE-PHOSPHORAMIDITE
  • 2'-fluoro-N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-CE-Phosphoramidite
  • 5'-O-DMT-2'-Fluoro-N6-Benzoyl-2'-deoxyadenosine 3'-CE phosphoramidite
  • 5'-O-DMT-2'-F-Benzoyl-Deoxyadenosine-CE Phosphoramidite
  • DMT-2'-F-dA(bz) Phosphoramidite
  • N6-Bz-5'-O-DMT-2'-fluoro-dA-CE
  • 5'-O-DMT-2'-F-N6- Benzoyl-2'-Deoxy Adenosine -3’-Cyanoethyl Phosphoramidite
  • 2'-Fluoro-N-Bz Adenosine Amidite
  • N6-Benzoyl-5’-O-(4, 4’-dimethoxytrityl)-2’-fluoro-2’-deoxyadenosine-3’-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite
  • 2’-F-dA(Bz) Amidite
  • 5'-ODMT-2'-Fluoro-N-Bz Adenosine-3'-OCEPA
  • Dmt-2'fluoro-da(bz) amidite
  • 2'-F-Bz-A Phosphoramidite
  • DMT-2'-F-dA(Bz)-CE Phosphoramidite
  • 2'-F-Bz-dA-CE-Phosphoramidite
  • 2'-fluoro-N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine-3'-CE-Phosphoramidite
  • 2'-F-dA(Bz)-CE-Phosphoramidite
  • 136834-22-5
  • Amidite