DMT-2′O-Methyl-rC(ac) Phosphoramidite

Product Name: DMT-2′O-Methyl-rC(ac) Phosphoramidite
CAS No.: 199593-09-4
Chemical Name: DMT-2′O-Methyl-rC(ac) Phosphoramidite
Synonyms: (2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite;Cytidine Impurity 14;2’-OMe -dC(Ac) Amidite;N4-Ac-5'-O-DMT-2'-OMe-C-CE;N4-Ac-5'-O-DMT-2'-OMe-C-CE;2'-OMe-Ac-C Phosphoramidite;Ac-2'-Ome-rC Phosphoramidite;2'-OMe-Ac-C Phosphoramidite;2'-OMe-C(Ac) Phosphoramidite;2'-OMe-N-Ac Cytidine?Amidite
CBNumber: CB21871625
Molecular Formula: C42H52N5O9P
Formula Weight: 801.86
MOL File: 199593-09-4.mol

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DMT-2′O-Methyl-rC(ac) Phosphoramidite Property

Melting point:: 102 - 104°C
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: powder
pka: 10.18±0.20(Predicted)
color: white to off-white
InChI: InChI=1/C42H52N5O9P/c1-28(2)47(29(3)4)57(54-26-12-24-43)56-38-36(55-40(39(38)52-8)46-25-23-37(44-30(5)48)45-41(46)49)27-53-42(31-13-10-9-11-14-31,32-15-19-34(50-6)20-16-32)33-17-21-35(51-7)22-18-33/h9-11,13-23,25,28-29,36,38-40H,12,26-27H2,1-8H3,(H,44,45,48,49)/t36-,38-,39-,40-,57?/s3
InChIKey: WNWUMIPFLOKTEZ-UAQIPLLRSA-N
SMILES: O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(NC(C)=O)=NC2=O)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,39,42,r|

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C213180
Product name: DMT-2′O-Methyl-rC(ac) Phosphoramidite
Purity: configured for PerkinElmer, configured for Polygen
Packaging: 1G
Price: $125
Updated: 2024/03/01

Sigma-Aldrich

Product number: C213100
Product name: DMT-2′O-Methyl-rC(ac) Phosphoramidite
Purity: ≥99% (31P-NMR)
Packaging: 100g
Price: $6540
Updated: 2024/03/01

Sigma-Aldrich

Product number: C213100
Product name: DMT-2′O-Methyl-rC(ac) Phosphoramidite
Purity: ≥99% (31P-NMR)
Packaging: 500g
Price: $32550
Updated: 2024/03/01

Sigma-Aldrich

Product number: C213180
Product name: DMT-2′O-Methyl-rC(ac) Phosphoramidite
Purity: configured for PerkinElmer, configured for Polygen
Packaging: 0.5g
Price: $92.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: C213130
Product name: DMT-2′O-Methyl-rC(ac) Phosphoramidite
Purity: configured for ABI
Packaging: 1g
Price: $84.7
Updated: 2024/03/01

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DMT-2′O-Methyl-rC(ac) Phosphoramidite Chemical Properties,Usage,Production

Uses

2''-OMe-Ac-C Phosphoramidite (CAS# 199593-09-4) is a nucleotide used in the solid-phase synthesis of phosphorothioate oligonucleotides using sulfurization byproducts for in situ capping.

Application

2′O-Methyl RNA nucleoside including DMT-2′O-Methyl-rC(ac) Phosphoramidite can be advantageously incorporated in nucleic acid probes with RNA or DNA for in-vivo or in-vitro applications to convey nuclease resistance.The unique combination of properties of 2′O-Methyl RNA had found widespread use in the fields of:
Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules

General Description

DMT-2′O-Methyl-rC(ac) Phosphoramidite is one of the 2′O-Methyl RNA monomers that feature methoxy groups at the 2′-position. Themethoxy groups are perfectly stable in all conditions employed in theassembly of oligonucleotides by automated phosphoramidite synthesis, andin all standard alkaline deprotection conditions.Its key features include:
High yield of crude oligonucleotides
Compatible with DNA synthesis
Can be employed together with DNA or RNA phosphoramidites in thesame synthesis to produce mixmer oligonucleotides
Recommended deprotection conditions are 8 hours at 55 °C usingconcentrated ammonia solution, or with AMA (concentrated ammonia/40% aqueous methylamine I/I, v/v) for 10 minutes at 65 °C
Purification and other downstream processing of fully modified 2′OMethyl RNA oligonucleotides are simpler than in the case of RNA, as nospecial precautions are required to provide protection against nucleolyticdegradation
Synthesis of 2′O-Methyl RNA oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 6minutes compared to 90 seconds for DNA monomers)
2′O-Methyl RNA phosphoramidites are also available with fast deprotection chemistry

DMT-2′O-Methyl-rC(ac) Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

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DMT-2′O-Methyl-rC(ac) Phosphoramidite Suppliers

China 134 India 3 United Kingdom 2 United States 12 Global 151

Nugene Biopharm Science (Hangzhou) Co., Ltd.

Tel: 13326014885
Email: service@nugene.com.cn
Country: China
ProdList: 51
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Wuhu Nuowei Chemical Technology Co., Ltd

Tel: 0553-8233716 18055326116
Email: kendoll@cqpharm.com
Country: China
ProdList: 647
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Hefei Huana Biomedical Technology Co.,Ltd

Tel: 17333066501
Email: shengwen.fang@huanaok.com.cn
Country: China
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Hefei Stongbio Co.,Ltd.

Tel: 15555170917
Email: sales@stongbio.com
Country: China
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Wuhu Huaren Science and Technology Co., Ltd.

Tel: 0553-0553-5842013-801 18155347026
Fax: 086-553-5843138
Email: sale@huarensh.com
Country: China
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Changshu New Venture

Tel: 13776233393
Email: janeabc@163.com
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Shanghai Bolu Biotechnology Co., Ltd

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Chemyouth Life Science（Suzhou）Co.,Ltd

Tel: 0512-52112288 13752065514
Email: jianwei@chemyouth.com
Country: China
ProdList: 49
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Wuhan Tangzhi Pharmaceutical Co., Ltd.

Tel: 027-63498076 13658392159
Email: sale@glycogene.com
Country: China
ProdList: 480
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Hongene Biotech Corporation

Tel: 021-64757213
Fax: 86-21-64700613
Email: info@hongene.com
Country: China
ProdList: 672
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View Lastest Price from DMT-2′O-Methyl-rC(ac) Phosphoramidite manufacturers

SHANGHAI NOVRIBO BIOTECH

Product: 2'-OMe-Ac-C CE Phosphoramidite 199593-09-4
Price: US $100.00/kg
Min. Order: 0.009999999776482582kg
Purity: 99%
Supply Ability: 5tons
Release date: 2023-03-21

Hefei Huana Biomedical Technology Co.,Ltd.

Product: N4-Ac-5'-O-DMT-2'-OMe-C-CE 199593-09-4
Price: US $0.00/mg
Min. Order: 100mg
Purity: ≥98%
Supply Ability: 20tons
Release date: 2023-03-09

Henan Aochuang Chemical Co.,Ltd.

Product: N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 199593-09-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-23

199593-09-4, DMT-2′O-Methyl-rC(ac) PhosphoramiditeRelated Search:

DMT-2′O-TBDMS-rU Phosphoramidite DMT-2'O-Methyl-rU Phosphoramidite Dmt-2'-f-dc(ac) amidite N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-6'-O-methylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite DMT-2'O-TBDMS-rA(bz) Phosphoramidite Ac-rC Phosphoramidite 2’-O-Methyl-rA(N-Bz)phosphoramidite 5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE DMT-dG(dmf) Phosphoramidite 2'-OMe-ibu-G Phosphoramidite Acetyl coenzyme A sodium salt N-ACETYL-L-TYROSINE ETHYL ESTER Acetylacetone Acetylferrocene tributyl acetocitrate Cytidine DMT-2′O-Methyl-rC(ac) Phosphoramidite Acetyl-resveratrol

2'-OMe-Ac-C Phosphoramidite

2’-O-Methyl-rC(N-Ac)Phosphoramidite

5'-O-DMT-2'-O-Me-rC(N-Ac)-3'-CEDPA

N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

(2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

5'-DMT-2'-OMe-rC(N-Ac) Phosphoramidite

N4-Acetyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite

DMT-2′O-Methyl-rC(ac) Phosphoramidite

2'-O-Methyl-N4-Acetyl-5'-O-DMT-Cytidine-3'-CE-Phosphoramidite

-5-(4-Acetamido-2-oxopyrimidin-1(2H)

Ac-2'-Ome-rC Phosphoramidite

2'-OMe-Ac-rC -CE Phosphoramidite

N4-acetyl-5'-O-(4, 4'-Dimethoxytrityl)-2'-O-methyl-Cytidine-3'-CE-Phosphoramidite

2'-OMe-Ac-C Phosphoramidite (~90%)

Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

2'-OMe-C(Ac) Phosphoramidite

N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite USP/EP/BP

5'-Dimethoxytrityl-N-acetyl-Cytidine,2'-O-methyl,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

N4-ACETYL-5-O-DMTr-2-O-METHYLCYTIDINE-3-O- CE-AMIDITE

5'-O-DMT-2'-OMe-Ac-C-CE-Phosphoramidite

Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

5'-O-DMT-N4-Acetyl-2'-O-methylcytidine 3'-CE phosphoramidite

5'-O-DMT-2'-OMe-Acetyl-Cytidine-CE Phosphoramidite

DMT-2-O-ME-C-CE Phosphoramidite

"DMT-2'-O-Me-dC(Ac) Phosphoramidite"

N4-Ac-5'-O-DMT-2'-OMe-C-CE

DMT-2’-OMe-C(Ac)-CE Phosphoramidite

2'-OMe-N-Ac Cytidine?Amidite

Cytidine Impurity 14

DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite

2’-OMe -dC(Ac) Amidite

5'-ODMT-2'-OMe-N-Ac Cytidine-3'-OCEPA

2'-OMe-Ac-C Phosphoramidite

DMT-2'-O-Me-C(Ac)-CE Phosphoramidite

N4-Ac-5'-O-DMT-2'-OMe-C-CE

5'-O-DMT-2'-OMe-Acetyl-Cytidine-CE Phosphoramidite

199593-09-4

C42H52N5O9P

Amidite