5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE

Product Name: 5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE
CAS No.: 134031-86-0
Chemical Name: 5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE
Synonyms: Rev T-5’-amidite;2'-OMe-U Phosphoramidite;2'-OMe-UPhosphoramidite,97%;2'-OMe-rU-CE Phosphoramidite;DMT-dT-CE Reverse Phosphoramidite;DMT-dT-CE-Inverted-Phosphoramidite;DMT-dT-5'-CE Reverse Phosphoramidite;3-DMT Thymidine 5-CED phosphoramidite;3'-O-DMT-thymidine 5'-CE phosphoramidite;3’-O-DMTr-thymidine 5’-CE phosphoramidite
CBNumber: CB7204898
Molecular Formula: C40H49N4O8P
Formula Weight: 744.81
MOL File: 134031-86-0.mol

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5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO: Sparingly soluble: 1-10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml
pka: 9.55±0.10(Predicted)

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Safety

HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B413210
Product name: 5''-O-[(N,N-diisopropylamino)-(2-cyanoethoxy)phosphinyl]-3''-O-(4,4''-dimethoxytrityl)-thymidine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FO162414
Product name: 3'-O-[bis(4-Methoxyphenyl)phenylmethyl]thymidine 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Ark Pharm

Product number: P000349277
Product name: 2'-OMe-U Phosphoramidite
Purity: 97%
Packaging: 100mg
Price: $118
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FO162414
Product name: 3'-O-[bis(4-Methoxyphenyl)phenylmethyl]thymidine 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
Packaging: 250mg
Price: $130
Updated: 2021/12/16

Ark Pharm

Product number: P000349277
Product name: 2'-OMe-U Phosphoramidite
Purity: 97%
Packaging: 250mg
Price: $176
Updated: 2021/12/16

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5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE Chemical Properties,Usage,Production

Description

2'-OMe-U Phosphoramidite can be for incorporation of an (otherwise unmodified) reverse (5' to 3') dT nucleobase within an oligonucleotide.

Uses

3’-O-DMTr-thymidine 5’-CE phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
[2] W. MIACHEL HANSON. Reversible Oligonucleotide Chain Blocking Enables Bead Capture and Amplification of T-Cell Receptor α and β Chain mRNAs[J]. Journal of the American Chemical Society, 2016, 138 35: 11073-11076. DOI: 10.1021/jacs.6b04465

5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE Suppliers

China 72 Germany 1 India 1 United Kingdom 3 United States 9 Global 86

Meryer (Shanghai) Chemical Technology Co., Ltd.

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134031-86-0, 5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINERelated Search:

2'-F-ibu-dG Phosphoramidite 2'-F-Bz-dC Phosphoramidite 2’-O-Methyl-rA(N-Bz)phosphoramidite DMT-dG(dmf) Phosphoramidite DMT-2′O-Methyl-rC(ac) Phosphoramidite 2'-OMe-ibu-G Phosphoramidite 3'-O-(4,4'-dimethoxytrityl)-thymidine 5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE

5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE

2'-OMe-U Phosphoramidite

2'-OMe-rU-CE Phosphoramidite

5'-O-[(DiisopropylaMino)-(2-cyanoethoxy)phosphinyl]-3'-O-(4,4'-diMethoxytrityl)thyMidine, 97%

3'-O-DMT-thymidine 5'-CE phosphoramidite

3'-O-[Bis(4-methoxyphenyl)phenylmethyl]thymidine 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

2'-O-Methyl-5'-O-DMT-Uridine-3'-CE-Phosphoramidite

3'-O-(4,4'-Dimethoxytrityl)-thymidine-5'-cyanoethyl-Phosphoramidite

DMT-dT-5'-CE Reverse Phosphoramidite

DMT-dT-CE Reverse Phosphoramidite

Thymidine, 3'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

3’-O-DMTr-thymidine 5’-CE phosphoramidite

3'-Dimethoxytrityl-2'-deoxyThymidine,5'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Rev T-5’-amidite

2'-OMe-UPhosphoramidite,97%

3-DMT Thymidine 5-CED phosphoramidite

3'-O-DMTr-thymidine 5'-CE phosphoramidite,97%

5'-O-[(Diisopropylamino)-(2-cyanoethoxy)phosphinyl]-3'-O-(4,4'-dimethoxytrityl)thymidine

DMT-dT-CE-Inverted-Phosphoramidite

3’-O-DMTr-thymidine ? 5’-CE phosphoramidite

134031-86-0

RNAi

Phosphoramidite