ChemicalBook > CAS DataBase List > 5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE

5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE

Product Name
5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE
CAS No.
134031-86-0
Chemical Name
5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE
Synonyms
Rev T-5’-amidite;idT CE Phosphoramidite;2'-OMe-U Phosphoramidite;2'-OMe-UPhosphoramidite,97%;2'-OMe-rU-CE Phosphoramidite;DMT-dT-CE Reverse Phosphoramidite;DMT-dT-CE-Inverted-Phosphoramidite;DMT-dT-5'-CE Reverse Phosphoramidite;3-DMT Thymidine 5-CED phosphoramidite;3'-O-DMT-thymidine 5'-CE phosphoramidite
CBNumber
CB7204898
Molecular Formula
C40H49N4O8P
Formula Weight
744.81
MOL File
134031-86-0.mol
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5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO: Sparingly soluble: 1-10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml
pka
9.55±0.10(Predicted)
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Safety

HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
B413210
Product name
5''-O-[(N,N-diisopropylamino)-(2-cyanoethoxy)phosphinyl]-3''-O-(4,4''-dimethoxytrityl)-thymidine
Packaging
50mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FO162414
Product name
3'-O-[bis(4-Methoxyphenyl)phenylmethyl]thymidine 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
Packaging
100mg
Price
$65
Updated
2021/12/16
Ark Pharm
Product number
P000349277
Product name
2'-OMe-U Phosphoramidite
Purity
97%
Packaging
100mg
Price
$118
Updated
2021/12/16
Biosynth Carbosynth
Product number
FO162414
Product name
3'-O-[bis(4-Methoxyphenyl)phenylmethyl]thymidine 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
Packaging
250mg
Price
$130
Updated
2021/12/16
Ark Pharm
Product number
P000349277
Product name
2'-OMe-U Phosphoramidite
Purity
97%
Packaging
250mg
Price
$176
Updated
2021/12/16
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5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE Chemical Properties,Usage,Production

Description

2'-OMe-U Phosphoramidite can be for incorporation of an (otherwise unmodified) reverse (5' to 3') dT nucleobase within an oligonucleotide.

Uses

3’-O-DMTr-thymidine 5’-CE phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
[2] W. MIACHEL HANSON. Reversible Oligonucleotide Chain Blocking Enables Bead Capture and Amplification of T-Cell Receptor α and β Chain mRNAs[J]. Journal of the American Chemical Society, 2016, 138 35: 11073-11076. DOI: 10.1021/jacs.6b04465

5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE Suppliers

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134031-86-0, 5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINERelated Search:

2'-F-ibu-dG Phosphoramidite 2'-F-Bz-dC Phosphoramidite 2’-O-Methyl-rA(N-Bz)phosphoramidite DMT-dG(dmf) Phosphoramidite DMT-2′O-Methyl-rC(ac) Phosphoramidite 2'-OMe-ibu-G Phosphoramidite 3'-O-(4,4'-dimethoxytrityl)-thymidine 5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE

  • 5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE
  • 2'-OMe-U Phosphoramidite
  • 2'-OMe-rU-CE Phosphoramidite
  • 5'-O-[(DiisopropylaMino)-(2-cyanoethoxy)phosphinyl]-3'-O-(4,4'-diMethoxytrityl)thyMidine, 97%
  • 3'-O-DMT-thymidine 5'-CE phosphoramidite
  • 3'-O-[Bis(4-methoxyphenyl)phenylmethyl]thymidine 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
  • 2'-O-Methyl-5'-O-DMT-Uridine-3'-CE-Phosphoramidite
  • 3'-O-(4,4'-Dimethoxytrityl)-thymidine-5'-cyanoethyl-Phosphoramidite
  • DMT-dT-5'-CE Reverse Phosphoramidite
  • DMT-dT-CE Reverse Phosphoramidite
  • Thymidine, 3'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 5'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • 3’-O-DMTr-thymidine 5’-CE phosphoramidite
  • 3'-Dimethoxytrityl-2'-deoxyThymidine,5'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • Rev T-5’-amidite
  • 2'-OMe-UPhosphoramidite,97%
  • 3-DMT Thymidine 5-CED phosphoramidite
  • 3'-O-DMTr-thymidine 5'-CE phosphoramidite,97%
  • 5'-O-[(Diisopropylamino)-(2-cyanoethoxy)phosphinyl]-3'-O-(4,4'-dimethoxytrityl)thymidine
  • DMT-dT-CE-Inverted-Phosphoramidite
  • 3’-O-DMTr-thymidine ? 5’-CE phosphoramidite
  • idT CE Phosphoramidite
  • 134031-86-0
  • RNAi
  • Phosphoramidite