ChemicalBook > CAS DataBase List > DMT-2′O-Methyl-rC(ac) Phosphoramidite

DMT-2′O-Methyl-rC(ac) Phosphoramidite

Product Name
DMT-2′O-Methyl-rC(ac) Phosphoramidite
CAS No.
199593-09-4
Chemical Name
DMT-2′O-Methyl-rC(ac) Phosphoramidite
Synonyms
(2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite;Cytidine Impurity 14;2’-OMe -dC(Ac) Amidite;N4-Ac-5'-O-DMT-2'-OMe-C-CE;N4-Ac-5'-O-DMT-2'-OMe-C-CE;2'-OMe-Ac-C Phosphoramidite;2'-OMe-N-Ac CytidineAmidite;Ac-2'-Ome-rC Phosphoramidite;2'-OMe-Ac-C Phosphoramidite;2'-OMe-C(Ac) Phosphoramidite
CBNumber
CB21871625
Molecular Formula
C42H52N5O9P
Formula Weight
801.86
MOL File
199593-09-4.mol
More
Less

DMT-2′O-Methyl-rC(ac) Phosphoramidite Property

Melting point:
102 - 104°C
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
powder
pka
10.18±0.20(Predicted)
color 
white to off-white
InChI
InChI=1/C42H52N5O9P/c1-28(2)47(29(3)4)57(54-26-12-24-43)56-38-36(55-40(39(38)52-8)46-25-23-37(44-30(5)48)45-41(46)49)27-53-42(31-13-10-9-11-14-31,32-15-19-34(50-6)20-16-32)33-17-21-35(51-7)22-18-33/h9-11,13-23,25,28-29,36,38-40H,12,26-27H2,1-8H3,(H,44,45,48,49)/t36-,38-,39-,40-,57?/s3
InChIKey
WNWUMIPFLOKTEZ-UAQIPLLRSA-N
SMILES
O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(NC(C)=O)=NC2=O)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,39,42,r|
More
Less

Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29349990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C213180
Product name
DMT-2′O-Methyl-rC(ac) Phosphoramidite
Purity
configured for PerkinElmer, configured for Polygen
Packaging
1G
Price
$125
Updated
2024/03/01
Sigma-Aldrich
Product number
C213100
Product name
DMT-2′O-Methyl-rC(ac) Phosphoramidite
Purity
≥99% (31P-NMR)
Packaging
100g
Price
$6540
Updated
2024/03/01
Sigma-Aldrich
Product number
C213100
Product name
DMT-2′O-Methyl-rC(ac) Phosphoramidite
Purity
≥99% (31P-NMR)
Packaging
500g
Price
$32550
Updated
2024/03/01
Sigma-Aldrich
Product number
C213180
Product name
DMT-2′O-Methyl-rC(ac) Phosphoramidite
Purity
configured for PerkinElmer, configured for Polygen
Packaging
0.5g
Price
$92.7
Updated
2024/03/01
Sigma-Aldrich
Product number
C213130
Product name
DMT-2′O-Methyl-rC(ac) Phosphoramidite
Purity
configured for ABI
Packaging
1g
Price
$84.7
Updated
2024/03/01
More
Less

DMT-2′O-Methyl-rC(ac) Phosphoramidite Chemical Properties,Usage,Production

Uses

2''-OMe-Ac-C Phosphoramidite (CAS# 199593-09-4) is a nucleotide used in the solid-phase synthesis of phosphorothioate oligonucleotides using sulfurization byproducts for in situ capping.

Application

2′O-Methyl RNA nucleoside including DMT-2′O-Methyl-rC(ac) Phosphoramidite can be advantageously incorporated in nucleic acid probes with RNA or DNA for in-vivo or in-vitro applications to convey nuclease resistance.The unique combination of properties of 2′O-Methyl RNA had found widespread use in the fields of:
Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules

General Description

DMT-2′O-Methyl-rC(ac) Phosphoramidite is one of the 2′O-Methyl RNA monomers that feature methoxy groups at the 2′-position. Themethoxy groups are perfectly stable in all conditions employed in theassembly of oligonucleotides by automated phosphoramidite synthesis, andin all standard alkaline deprotection conditions.Its key features include:
High yield of crude oligonucleotides
Compatible with DNA synthesis
Can be employed together with DNA or RNA phosphoramidites in thesame synthesis to produce mixmer oligonucleotides
Recommended deprotection conditions are 8 hours at 55 °C usingconcentrated ammonia solution, or with AMA (concentrated ammonia/40% aqueous methylamine I/I, v/v) for 10 minutes at 65 °C
Purification and other downstream processing of fully modified 2′OMethyl RNA oligonucleotides are simpler than in the case of RNA, as nospecial precautions are required to provide protection against nucleolyticdegradation
Synthesis of 2′O-Methyl RNA oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 6minutes compared to 90 seconds for DNA monomers)
2′O-Methyl RNA phosphoramidites are also available with fast deprotection chemistry

DMT-2′O-Methyl-rC(ac) Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

DMT-2′O-Methyl-rC(ac) Phosphoramidite Suppliers

China 144 India 3 United Kingdom 2 United States 12 Global 161
Nugene Biopharm Science (Hangzhou) Co., Ltd.
Tel
13326014885
Email
service@nugene.com.cn
Country
China
ProdList
51
Advantage
58
Wuhu Nuowei Chemical Technology Co., Ltd
Tel
0553-8233716 18055326116
Email
kendoll@cqpharm.com
Country
China
ProdList
645
Advantage
58
Hefei Huana Biomedical Technology Co.,Ltd
Tel
17333066501
Email
shengwen.fang@huanaok.com.cn
Country
China
ProdList
95
Advantage
58
Hefei Stongbio Co.,Ltd.
Tel
15555170917
Email
sales@stongbio.com
Country
China
ProdList
493
Advantage
58
Wuhu Huaren Science and Technology Co., Ltd.
Tel
0553-0553-0553-5842013-801-801 18155347026
Fax
086-553-5843138
Email
jinhuaren@huarensh.com
Country
China
ProdList
295
Advantage
64
Chemyouth Life Science（Suzhou）Co.,Ltd
Tel
0512-52112288 13752065514
Email
jianwei@chemyouth.com
Country
China
ProdList
49
Advantage
58
Wuhan Tangzhi Pharmaceutical Co., Ltd.
Tel
0532-88500810 13658392159
Email
sale@glycogene.com
Country
China
ProdList
837
Advantage
58
Asymchem Labs.
Tel
17347534561
Email
liujingjing0710@asymchem.com.cn
Country
China
ProdList
435
Advantage
58
Hongene Biotech Corporation
Tel
021-64757213
Fax
86-21-64700613
Email
info@hongene.com
Country
China
ProdList
672
Advantage
61
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Tianjin Scaxchem Limited Compnay
Tel
022-022-25327698 18920479040
Email
sales@cosychem.com
Country
China
ProdList
589
Advantage
55
Wuhu Nuowei Chemical Technology Co., Ltd
Tel
0553-8233716 18055326116
Email
sales@nuowei-chem.com
Country
China
ProdList
951
Advantage
55
Hangzhou Dingyan Chem Co., LTD
Tel
0571-87157530-8007 13868066926
Fax
0571-87156470
Email
sales@dingyanchem.com
Country
China
ProdList
2190
Advantage
58
Artis Biotech Co. Ltd.
Tel
0575-18780151478 18582380095
Fax
0575-89298961
Email
sales@artisbio.com
Country
China
ProdList
2966
Advantage
58
Shanghai Qiao Chemical Science Co., Ltd
Tel
021-58892003
Email
info@qiaochem.com
Country
China
ProdList
5904
Advantage
65
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
Suzhou GenePharma Co., Ltd.
Tel
+86 512 86668828 ,8026
Fax
+86 512 86668828
Email
chem@genepharma.com
Country
China
ProdList
46
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-50664929, 13971561712
Fax
027-50664927 / QQ: 3452835437
Email
hubxys2001@163.com
Country
China
ProdList
1437
Advantage
55
Wellman Pharmaceutical Group Limited
Tel
027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
4027
Advantage
58
Aikon International Limited
Tel
025-66113011 13155353615
Fax
(7)02557626880
Email
qzhang@aikonchem.com
Country
China
ProdList
15394
Advantage
58
SHANGHAI FDC-CHEMICAL CO.,LTD
Tel
021-61469567 13482353728
Fax
021-61161605
Email
sales@fdc-chemical.com
Country
China
ProdList
14377
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 18016230971
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25004
Advantage
58
Maanshan geneyan biotech Co.,LTD
Tel
18913822354
Email
market@geneyan-bio.com
Country
China
ProdList
299
Advantage
58
Shandong utilizing biological technology co., LTD
Tel
15966937598
Fax
3407640895 3071519937
Email
3407650895@qq.com
Country
China
ProdList
1240
Advantage
58
Chengdu Zen Sunda Bio-pharmaceutical Technology Co., Ltd.
Tel
19981275275
Email
sales@zsdbiopharm.com
Country
China
ProdList
285
Advantage
58
SHANGHAI SEAGA BIO-TECH CO.,LTD
Tel
13764598896
Email
grace8018@163.com
Country
China
ProdList
290
Advantage
58
Shanghai Xianggeng Technology Development Co. Ltd.
Tel
021-021-56152668 18116302010
Fax
18116300787
Email
sharing@sharingtechcn.com
Country
China
ProdList
501
Advantage
58
Beijing Minruida Technology Co., Ltd.
Tel
010-82387566 18001021521;
Fax
82387566-801
Email
sales@mreda.com.cn
Country
China
ProdList
10789
Advantage
58
Henan Alfa Chemical Co., Ltd
Tel
Country
China
ProdList
10947
Advantage
58
NewCan Biotech Limited
Tel
+86-0571-86912261 +8613735419629
Email
sales@newcanbio.com
Country
China
ProdList
9981
Advantage
58
ANHUI WITOP BIOTECH CO., LTD
Tel
+8615255079626
Email
eric@witopchemical.com
Country
China
ProdList
23541
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
22784
Advantage
58
Henan Weituxi Chemical Technology Co., Ltd.
Tel
0371-63284658 18135795563
Fax
QQ:2885349392
Email
2885349392@qq.com
Country
China
ProdList
10003
Advantage
58
Nanjing Fenglin Biotechnology Co., Ltd.
Tel
13601780782
Email
zangwei03@aliyun.com
Country
CHINA
ProdList
10
Advantage
58
Guangdong Wengjiang Chemical Reagent Co., Ltd.
Tel
0751-2886766 13927870850
Fax
0751-2886756
Email
3001267247@qq.com
Country
China
ProdList
9974
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39894
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49374
Advantage
58
Hubei huizepu Pharmaceutical Technology Co., Ltd
Tel
027-027-027-59212684 19371278702
Fax
QQ:2188308251
Email
p19107121455@163.com
Country
China
ProdList
3011
Advantage
58
Antai Fine Chemical Technology Co.,Limited
Tel
18503026267
Email
info@antaichem.com
Country
CHINA
ProdList
9636
Advantage
58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tel
+86-021-61551413 +8618813727289
Email
contact@trustwe.com
Country
China
ProdList
5738
Advantage
58
Shanghai meikai technology co., ltd
Tel
021-18721550-091 18721550091
Fax
微信18721550091
Email
yangdong@pharma.com
Country
China
ProdList
4121
Advantage
58
Jiaxing Hengrui Biotechnology Co. LTD
Tel
0573-0573-82672231 13757365595
Fax
QQ：715584339
Email
regen_chemical1@163.com
Country
China
ProdList
4946
Advantage
58
Zhejiang Huida Biotech Co., LTD
Tel
0571-89903882 13626641628
Email
jiangnan@huidabiotech.com
Country
China
ProdList
3656
Advantage
58
Hangzhou Jinghao Biotechnology Co., LTD
Tel
17513242016 17513242016
Fax
QQ:1576861551
Email
1576861551@qq.com
Country
China
ProdList
2800
Advantage
58
More
Less

View Lastest Price from DMT-2′O-Methyl-rC(ac) Phosphoramidite manufacturers

Hefei Huana Biomedical Technology Co.,Ltd.
Product
N4-Ac-5'-O-DMT-2'-OMe-C-CE 199593-09-4
Price
US $0.00/mg
Min. Order
100mg
Purity
≥98%
Supply Ability
20tons
Release date
2023-03-09
SHANGHAI NOVRIBO BIOTECH
Product
2'-OMe-Ac-C CE Phosphoramidite 199593-09-4
Price
US $100.00/kg
Min. Order
0.009999999776482582kg
Purity
99%
Supply Ability
5tons
Release date
2023-03-21
Henan Aochuang Chemical Co.,Ltd.
Product
N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 199593-09-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-23

199593-09-4, DMT-2′O-Methyl-rC(ac) PhosphoramiditeRelated Search:

DMT-2′O-TBDMS-rU Phosphoramidite DMT-2'O-Methyl-rU Phosphoramidite Dmt-2'-f-dc(ac) amidite N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-6'-O-methylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite DMT-2'O-TBDMS-rA(bz) Phosphoramidite Ac-rC Phosphoramidite 2’-O-Methyl-rA(N-Bz)phosphoramidite 5'-O-[(N,N-DIISOPROPYLAMINO)-(2-CYANOETHOXY)PHOSPHINYL]-3'-O-(4,4'-DIMETHOXYTRITYL)-THYMIDINE DMT-dG(dmf) Phosphoramidite 2'-OMe-ibu-G Phosphoramidite Acetyl coenzyme A sodium salt N-ACETYL-L-TYROSINE ETHYL ESTER Acetylacetone Acetylferrocene tributyl acetocitrate Cytidine DMT-2′O-Methyl-rC(ac) Phosphoramidite Acetyl-resveratrol

  • 2'-OMe-Ac-C Phosphoramidite
  • 2’-O-Methyl-rC(N-Ac)Phosphoramidite
  • 5'-O-DMT-2'-O-Me-rC(N-Ac)-3'-CEDPA
  • N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • (2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
  • 5'-DMT-2'-OMe-rC(N-Ac) Phosphoramidite
  • N4-Acetyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite
  • DMT-2′O-Methyl-rC(ac) Phosphoramidite
  • 2'-O-Methyl-N4-Acetyl-5'-O-DMT-Cytidine-3'-CE-Phosphoramidite
  • -5-(4-Acetamido-2-oxopyrimidin-1(2H)
  • Ac-2'-Ome-rC Phosphoramidite
  • 2'-OMe-Ac-rC -CE Phosphoramidite
  • N4-acetyl-5'-O-(4, 4'-Dimethoxytrityl)-2'-O-methyl-Cytidine-3'-CE-Phosphoramidite
  • 2'-OMe-Ac-C Phosphoramidite (~90%)
  • Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • 2'-OMe-C(Ac) Phosphoramidite
  • N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite USP/EP/BP
  • 5'-Dimethoxytrityl-N-acetyl-Cytidine,2'-O-methyl,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
  • N4-ACETYL-5-O-DMTr-2-O-METHYLCYTIDINE-3-O- CE-AMIDITE
  • 5'-O-DMT-2'-OMe-Ac-C-CE-Phosphoramidite
  • Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
  • 5'-O-DMT-N4-Acetyl-2'-O-methylcytidine 3'-CE phosphoramidite
  • 5'-O-DMT-2'-OMe-Acetyl-Cytidine-CE Phosphoramidite
  • DMT-2-O-ME-C-CE Phosphoramidite
  • "DMT-2'-O-Me-dC(Ac) Phosphoramidite"
  • N4-Ac-5'-O-DMT-2'-OMe-C-CE
  • DMT-2’-OMe-C(Ac)-CE Phosphoramidite
  • 2'-OMe-N-Ac Cytidine?Amidite
  • DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite
  • 2’-OMe -dC(Ac) Amidite
  • 5'-ODMT-2'-OMe-N-Ac Cytidine-3'-OCEPA
  • 2'-OMe-Ac-C Phosphoramidite
  • DMT-2'-O-Me-C(Ac)-CE Phosphoramidite
  • N4-Ac-5'-O-DMT-2'-OMe-C-CE
  • 5'-O-DMT-2'-OMe-Acetyl-Cytidine-CE Phosphoramidite
  • 2'-OMe-C(Ac)-CE-Phosphoramidite
  • 2'-OMe-Ac-C CE Phosphoramidite
  • N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
  • 2'-OMe-rC(Ac)Phosphoramidite
  • N4-Acetyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite
  • 2'-OMe-N-Ac CytidineAmidite
  • DMT-2'O-METHYL-RC(AC) PHOSPHORAMIDITE
  • Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite
  • Cytidine Impurity 14
  • 199593-09-4
  • C42H52N5O9P
  • Amidite