Dmt-2'fluoro-da(bz) amidite
- Product Name
- Dmt-2'fluoro-da(bz) amidite
- CAS No.
- 136834-22-5
- Chemical Name
- Dmt-2'fluoro-da(bz) amidite
- Synonyms
- 2’-F-dA(Bz) Amidite;2'-F-Bz-A Phosphoramidite;Bz-2'-F-dA Phosphoramidite;Dmt-2'fluoro-da(bz) amidite;Dmt-2'fluoro-da(bz) amidite;2'-F-N6-Bz-dA phosphoramidite;2'-F-Bz-dA-CE-Phosphoramidite;2'-F-dA(Bz)-CE Phosphoramidite;N6-Bz-5'-O-DMT-2'-fluoro-dA-CE;2'-F-dA(Bz)-CE-Phosphoramidite
- CBNumber
- CB13141318
- Molecular Formula
- C47H51FN7O7P
- Formula Weight
- 875.92
- MOL File
- 136834-22-5.mol
Dmt-2'fluoro-da(bz) amidite Property
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- Powder
- pka
- 7.87±0.43(Predicted)
- InChI
- InChI=1/C47H51FN7O7P/c1-8-60-63(55(31(2)3)46(4,5)28-49)62-41-38(61-45(39(41)48)54-30-52-40-42(50-29-51-43(40)54)53-44(56)32-15-11-9-12-16-32)27-59-47(33-17-13-10-14-18-33,34-19-23-36(57-6)24-20-34)35-21-25-37(58-7)26-22-35/h9-26,29-31,38-39,41,45H,8,27H2,1-7H3,(H,50,51,53,56)/t38-,39-,41-,45-,63?/s3
- InChIKey
- ZDIBABNMVQPXHU-JWQXGDSTNA-N
- SMILES
- C(NC1C2=C(N=CN=1)N([C@H]1[C@H](F)[C@H](OP(OCC)N(C(C)C)C(C#N)(C)C)[C@@H](COC(C3=CC=C(OC)C=C3)(C3=CC=C(OC)C=C3)C3=CC=CC=C3)O1)C=N2)(=O)C1=CC=CC=C1 |&1:9,10,12,27,r|
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- J64064
- Product name
- N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-(2-cyanoethyl diisopropylphosphoramidite), 98%
- Packaging
- 1g
- Price
- $123.65
- Updated
- 2024/03/01
- Product number
- B208313
- Product name
- (2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl(2-cyanoethyl)Diisopropylphosphoramidite
- Packaging
- 1g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 2404CT
- Product name
- Dmt-2'fluoro-da(bz)amidite
- Packaging
- 500mg
- Price
- $151
- Updated
- 2021/12/16
- Product number
- 2404CT
- Product name
- Dmt-2'fluoro-da(bz)amidite
- Packaging
- 1g
- Price
- $218
- Updated
- 2021/12/16
- Product number
- PB08393
- Product name
- N6-Benzoyl-2'-deoxy-5'-O-DMT-2'-fluoroadenosine 3'-CE phosphoramidite
- Packaging
- 2g
- Price
- $220
- Updated
- 2021/12/16
Dmt-2'fluoro-da(bz) amidite Chemical Properties,Usage,Production
Chemical Properties
White to Light yellow powder to crystal.
Uses
(2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-fluorotetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (Dmt-2'fluoro-da(bz) amidite) is an adenosine derivative used in the preparation of modified nucleotides to improve metabolic stability and ellicit gene silencing, and in the synthesis of microRNA inhibitors.
Synthesis
3-((Bis(diisopropylamine)phosphanyl)oxy)propanenitrile (6.42 g, 21.3 mmol, 6.77 mL, 1.8 eq) was added to a solution of N-(9-((2R,3R,4R,5R)-5-((bis(4- methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-9H- purine-6-yl)benzamide (8.0 g, 11.8 mmol, 1.0 eq) in DCM (42 mL) at 0 °C followed by DCI (2.24 g, 18.9 mmol, 1.6 eq). The mixture was warmed to 25 °C and stirred for 3 hours. Two parallel reactions were carried out. The combined remedies were then diluted with DCM (150 mL), the organic layer was washed with sat NaHCO3 solution (200 mL) and brine (100 mL), dried over Na2SO4, filtered and concentrated, the crude was purified by column chromatography to give Dmt-2'fluoro-da(bz) amidite (18.0 g, 18.5 mmol, 78.1% yield, 90% purity) as a white solid.
Dmt-2'fluoro-da(bz) amidite Preparation Products And Raw materials
Raw materials
Preparation Products
Dmt-2'fluoro-da(bz) amidite Suppliers
View Lastest Price from Dmt-2'fluoro-da(bz) amidite manufacturers
- Product
- 2'-F-dA(Bz) CE Phosphoramidite 136834-22-5
- Price
- US $100.00/kg
- Min. Order
- 0.009999999776482582kg
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2023-03-21
- Product
- N6-Bz-5'-O-DMT-2'-fluoro-dA-CE 136834-22-5
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- ≥99%
- Supply Ability
- 20tons
- Release date
- 2023-03-09
- Product
- N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoroadenosine 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] 136834-22-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26