ChemicalBook > CAS DataBase List > IPI-549
IPI-549
- Product Name
- IPI-549
- CAS No.
- 1693758-51-8
- Chemical Name
- IPI-549
- Synonyms
- Eganelisib;IPI-549;CS-2414;IPI-549(IPI549);IPI549 (Eganelisib);Eganelisib (IPI-549);IPI-549; IPI 549; IPI549.;IPI-549, 98%, a potent and selective PI3Kγ Inhibitor;(S)-2-amino-N-(1-(8-((1-methyl-1H-pyrazol-4-yl)ethynyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-Amino-N-[(1S)-1-[1,2-dihydro-8-[2-(1-methyl-1H-pyrazol-4-yl)ethynyl]-1-oxo-2-phenyl-3-isoquinolinyl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
- CBNumber
- CB13147769
- Molecular Formula
- C30H24N8O2
- Formula Weight
- 528.56
- MOL File
- 1693758-51-8.mol
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IPI-549 Property
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to at least 25 mg/ml)
- form
- solid
- pka
- 10.81±0.46(Predicted)
- color
- Pale yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- CAS DataBase Reference
- 1693758-51-8
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Safety
- HS Code
- 2933998090
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 26416
- Product name
- IPI-549
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 26416
- Product name
- IPI-549
- Packaging
- 25mg
- Price
- $384
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 26416
- Product name
- IPI-549
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 26416
- Product name
- IPI-549
- Packaging
- 10mg
- Price
- $223
- Updated
- 2024/03/01
TRC
- Product number
- I739410
- Product name
- IPI549
- Packaging
- 5mg
- Price
- $95
- Updated
- 2021/12/16
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IPI-549 Chemical Properties,Usage,Production
Description
IPI-549 (1693758-51-8) is a potent and highly selective inhibitor of PI3K-γ in both biochemical (IC50?= 16 nM) and cellular (IC50?= 12.2 nM) assays.1?Macrophage PI3K-γ has been found to be a critical switch between immune stimulation and suppression.2?IPI-549 has been used to reshape tumor immune microenvironments and promote cytotoxic T-cell-mediated tumor regression. Resistance to immune checkpoint blockade in 4T1 and B16-GMCSF tumors was overcome when anti-PD-1 or anti-CTLA4 therapies were combined with PI3K-γ inhibition via IPI-549.3?IPI-549 mono-treatment also resulted in tumor growth inhibition in several cancer cell lines.3?IPI-549 has also been shown to modulate P-glycoprotein-mediated multidrug resistance.4
Uses
IPI-549 is a selective phosphoinositide-3-kinase (PI3Kγ) Inhibitor. PI3Kγ inhibitors can be used to develop potential treatment for inflammatory and autoimmune diseases.
References
1) Evans?et al.?(2016)?Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-gamma Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate; ACS Med. Chem. Lett.?7?862 2) Kaneda?et al.?(2016)?PI3Kγ is a molecular switch that controls immune suppression; Nature?539?437 3) De Henau?et al.?(2016);?Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells; Nature?539?443 4) De Vera?et al. (2019);?Immuno-oncology agent IPI-549 is a modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated multidrug resistance (MDR) in cancer: In vitro and in vivo; Cancer Letters?442?91
IPI-549 Preparation Products And Raw materials
Raw materials
Preparation Products
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