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W123 Exclusive

Product Name
W123 Exclusive
CAS No.
1345982-24-2
Chemical Name
W123 Exclusive
Synonyms
W123 Exclusive;JXZQHAWCGSVWRW-UHFFFAOYSA-N;β-Alanine, N-[2-[(3-hexylphenyl)amino]-2-oxoethyl]-
CBNumber
CB13152994
Molecular Formula
C17H26N2O3
Formula Weight
306.4
MOL File
1345982-24-2.mol
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W123 Exclusive Property

Boiling point:
527.2±45.0 °C(Predicted)
Density 
1.116±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≤2mg/ml in ethanol;15mg/ml in DMSO;25mg/ml in dimethyl formamide
form 
crystalline solid
pka
3.58±0.12(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10010992
Product name
W123
Purity
≥98%
Packaging
1mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
10010992
Product name
W123
Purity
≥98%
Packaging
5mg
Price
$356
Updated
2024/03/01
Cayman Chemical
Product number
10010992
Product name
W123
Purity
≥98%
Packaging
10mg
Price
$629
Updated
2024/03/01
AK Scientific
Product number
2189DC
Product name
3-[[2-(3-Hexylanilino)-2-oxoethyl]amino]propanoicacid
Packaging
10mg
Price
$799
Updated
2021/12/16
ApexBio Technology
Product number
C4064
Product name
W123
Packaging
5mg
Price
$400
Updated
2021/12/16
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W123 Exclusive Chemical Properties,Usage,Production

Definition

ChEBI: Beta-alanine, n-[2-[(3-hexylphenyl)amino]-2-oxoethyl]- is an amino acid amide.

Biological Activity

w123, an analog of fty720, is a competitive antagonist of sphingosine-1-phosphate (s1p) type 1 receptor (s1p1), which is measured by gtpγs activation, cell migration, ligand-induced receptor internalization, and mitogen-activated protein kinase recruitment.s1p plays a vital role in the entire human body, involving in mediating skin, vascular endothelial, and immune cells. s1p1, also known as edg-1, is one of the five high affinity g protein-coupled s1p receptors and mediates lymphoid, endothelial, and neuronal cell responses to s1p.

in vitro

w123 reversed the effects of s1p1 agonists, fty720, p-fty720, and sew2871. superoxide dismutase and catalase activity level seen in w123-treated groups were reversely improved via antagonizing the s1p receptor induced by w123. w123 reduced phosphorylated levels of pi3k, akt, and foxo3a in different ways, indicating that the activation of s1p1 receptor in the context of oxidative stress elicited the phosphorylation/activation of pi3k/akt and thus the phosphorylation/inactivation of foxo3a which in turn promoted pc12 cell survival [1].

References

[1]. safarian, f., khallaghi, b., ahmadiani, a., & dargahi, l. activation of s1p1 receptor regulates pi3k/akt/foxo3a pathway in response to oxidative stress in pc12 cells. journal of molecular neuroscience. 2014; 56(1): 177-187.

W123 Exclusive Preparation Products And Raw materials

Raw materials

Preparation Products

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W123 Exclusive Suppliers

ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11217
Advantage
58
Nanjing Tengyi Biotechnology Co., Ltd
Tel
025-58851786 17714337195
Email
sales@tybiochem.com
Country
China
ProdList
7411
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11974
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58